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Search Results for " post-translationally "

Targets Recommended: Potassium Channel

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T14984	CLP257	Potassium Channel	Membrane transporter/Ion channel
	CLP257 是有效的 K+-Cl- 协同转运蛋白 KCC2 选择性激活剂 (EC50: 616 nM)。它可减轻神经性疼痛大鼠的超敏反应，并在翻译后调节质膜 KCC2 蛋白周转。它在 KCC2 活性降低的神经元中恢复受损的 Cl- 转运。
T34664	SMN2-Stablizer-27 SMN2-Stablizer 27,SMN2 Stablizer-27	Others	Others
	SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).
T22676	Prothrombin (474-477) [Mus musculus]	Others	Others
	Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to
T35691	Myristoyl Coenzyme A (hydrate)	Others	Others
	Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid . It is a substrate for N-myristoyltransferase during myristoylation, a process that adds a myristoyl group to proteins either during translation to modify protein activity or post-translationally in apoptotic cells. It is also a substrate in the de novo synthesis of phosphatidylinositol .
T84798	Azido Myristic Acid	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	叠氮肉豆蔻酸，一种含叠氮基团的点击化学试剂，通过一简单而可靠的两步法进行标记与检测，用于鉴定及表征翻译后的肉豆蔻酸蛋白。
T84775	15-Azido-pentadecanoic acid Azido Palmitic Acid	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	15-Azido-pentadecanoic acid是一种含有Azide基团的化学试剂，用于通过简单且稳健的两步鉴定和表征翻译后棕榈酸化蛋白的技术，同时也是一种点击化学试剂。它能够参与铜催化的叠氮-炔环加成反应（CuAAc），与含有Alkyne基团的分子发生反应；亦可通过与含有DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应（SPAAC）反应。

化合物

CLP257

Cat.No: T14984

Synonym:

Target: Potassium Channel

SMN2-Stablizer-27

Cat.No: T34664

Synonym: SMN2-Stablizer 27,SMN2 Stablizer-27

Target: Others

Prothrombin (474-477) [Mus musculus]

Cat.No: T22676

Synonym:

Target: Others

Myristoyl Coenzyme A (hydrate)

Target: Others, ADC Linker

15-Azido-pentadecanoic acid

Cat.No: T84775

Synonym: Azido Palmitic Acid

Target: Others, ADC Linker

Cat. No.	Product Name	Target	Signaling Pathways
T4514	N-Acetyl-D-Glucosamine N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc	Endogenous Metabolite	Metabolism
	N-Acetyl-D-Glucosamine (NAG) 是葡萄糖的单糖衍生物。

天然产物

N-Acetyl-D-Glucosamine

Cat.No: T4514

Synonym: N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00395	Insulin Protein, Human, Recombinant IDDM1,MODY10,ILPR,IDDM2,IRDN,IDDM,insulin,INS	Human	P. pastoris (Yeast)
	INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ...
TMPY-00021	PADI4 Protein, Human, Recombinant (His) PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI...	Human	Baculovirus Insect Cells
	Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres...
TMPJ-01062	HAMP Protein, Human, Recombinant (GST) Liver-expressed antimicrobial peptide 1,HEPC,LEAP1,Putative ...	Human	E. coli
	Hepcidin（HAMP）is a secreted protein that belongs to the hepcidin family.It is expressed in liver, heart and brain. It is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta sheet structure...
TMPK-00457	HGFR/c-Met Protein, Human, Recombinant (His & Avi) cMET,Met (c-Met),MET,HGF/SF receptor,SF receptor,RCCP2,AUTS9...	Human	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...
TMPK-00499	HGFR/c-Met Protein, Cynomolgus, Recombinant (His) MET,oncogene MET,cMET,SF receptor,HGF/SF receptor,AUTS9,Met ...	Cynomolgus	HEK293 Cells
	c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ...