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Search Results for " polymerases "

Targets Recommended: DNA/RNA Synthesis

28

抑制剂 & 化合物

4

天然产物

4

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8647	BCH001	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BCH001 是喹啉衍生物，是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。
T5539	GS-443902 瑞德西韦代谢物	Nucleoside Antimetabolite/Analog; HCV Protease; SARS-CoV; DNA/RNA Synthesis; RSV; Drug Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Remdesivir triphosphate 是一种有效的病毒 RNA 依赖的 RNA 聚合酶抑制剂，对RSVRdRp 和 HCVRdRp 的IC50分别为 1.1 µM 和 5 µM。它是 Remdesivir 的活性三磷酸代谢物。
T4377	Pimodivir VX-787	Influenza Virus	Microbiology/Virology
	Pimodivir (VX-787) 是一种通过口服的甲型流感病毒聚合酶抑制剂，与病毒 PB2 亚基相互作用。
T9618	HeE1-2Tyr	SARS-CoV	Microbiology/Virology
	HeE1-2Tyr 是一种pyridobenzothiazole，抑制黄病毒 RNA 依赖性 RNA 聚合酶。HeE1-2Tyr 在体外对Dengue, West Nile 和 SARS-CoV-2 RdRps 有显著的抑制活性(IC50为 27.6 µM) 。
T7042	1,5-Isoquinolinediol	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	1,5-Isoquinolinediol 是一种多聚（ADP-核糖）合成酶抑制剂，对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。
T16945	Streptolydigin Portamycin	Antibacterial	Microbiology/Virology
	Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki: 18 μM and a Kd: 15 μM).
T1454L	Acyclovir sodium Aciclovir sodium	Others	Others
	Acyclovir sodium is an antimetabolite. Acyclovir sodium inhibits HSV-specified DNA polymerases and prevents further viral DNA synthesis.
T35657	3'-Deoxyuridine-5'-triphosphate	Others	Others
	3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-tri...
T75344	NCT-TFP	Others	Others
	NCT-TFP 是 PARP 探针，用于鉴定聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂。
T69130	Zorubicin Rubidazon ; Rubidazone,Rubidazone,Rubidazon	Others	Others
	Zorubicin (Rubidazon) 是Daunorubicin 的衍生物。Zorubicin 与拓扑异构酶 II 相互作用，抑制DNA 聚合酶。Zorubicin 可用于急性白血病和肉瘤的研究。
T70961	Dmb-rifampicin	Others	Others
	Dmb-rifampicin is an inhibitor of nucleic acid polymerases.
T13852	PSI-7409 tetrasodium	Others	Others
	PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977)(IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively).
T29431	4'-Azidothymidine 5'-triphosphate Adrt TP,Adrt-TP,AdrtTP	Others	Others
	4'-Azidothymidine 5'-triphosphate exerts selectively action on both reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta.
T70284	Epolactaene	Others	Others
	Epolactaene is a neuritogenic compound in human neuroblastoma cells which selectively inhibit the activities of mammalian DNA polymerases and human DNA topoisomerase II.
T69384	AF-013	Others	Others
	AF-013 is a rifamycin derivative -- specifically an O-n-octyloxime of 3-formylrifamycin SV -- which acts as an inhibitor of nucleic acid polymerases.
T32050	HCV-371 HCV 371	Others	Others
	HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ and other unrelated viral polymerase
T37910	Tenofovir diphosphate triethylamine	Others	Others
	Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive inhibitor of DNA polymerases for dATP, functioning as a substrate for HIV type 1 reverse transcriptase (HIV-1 RT)[1].
T37909	Tenofovir diphosphate	Others	Others
	Tenofovir diphosphate (TFV-DP) is a competitive inhibitor of DNA polymerases, specifically targeting dATP, and it serves as a substrate for the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1)[1].
T73983	Cidofovir diphosphate tri(triethylamine)	Others	Others
	Cidofovir diphosphate tri triethylamine 是西多福韦的细胞内活性代谢物。diphosphate tri triethylamine 是病毒 DNA 聚合酶的选择性抑制剂，对 HCMV，HSV-1和 HSV-2的 Ki 值分别为 6.6，0.86 和 1.4 μM。
T35658	3'-Deoxyuridine-5'-triphosphate trisodium	Others	Others
	3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1]. 3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polym...
T40359	Thio-ITP 6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate	Others	Others
	Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II.
T38761	GS-443902 trisodium GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium,瑞德西韦代谢物三钠盐	Others	Others
	GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC 50 s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).
T36698	9(Z),11(E),13(E)-Octadecatrienoic Acid	Others	Others
	9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1...
T80760	XSJ2-46	Influenza Virus	Microbiology/Virology
	XSJ2-46，一种5'-氨基NI类似物，表现为有效的抗病毒药物，尤其针对Zika病毒。它通过抑制RNA依赖性RNA聚合酶（RdRp），展示出其活性，具有8.78 μM的IC50值。
T36888	9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester	Others	Others
	9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPA...
T36889	Methyl alpha-eleostearate	Others	Others
	Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supple...
T35983	Carotenoid Mixture	Others	Others
	Carotenoid mixture is a mixture of carotenoids that contains the antioxidative and anti-inflammatory carotenoid capsanthin and the antioxidative vitamin A precursor β-carotene , as well as additional carotenoids and carotenoid esters.1,2,3,4 1.Kim, J.S., Lee, W.M., Rhee, H.C., et al.Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communicationChem. Biol. Interact.254146-155(2016) 2.Na...
T37106	2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)	Others	Others
	2'-Deoxyadenosine-5'-triphosphate (dATP) is a purine nucleotide and derivative of the nucleic acid adenosine 5'-triphosphate .1dATP is a substrate for DNA polymerase in the synthesis of DNA.2It is a noncompetitive inhibitor of ribonucleotide reductases, which provides feedback inhibition during DNA synthesis.1dATP has commonly been used in DNA synthesis, sequencing, and labeling in research applications.3,4dATP accumulates in adenosine deaminase deficiency, a disorder characterized by mutations ...

化合物

Cat.No: T8647

Target: DNA/RNA Synthesis

Cat.No: T5539

Synonym: 瑞德西韦代谢物

Target: Nucleoside Antimetabolite/Analog, HCV Protease, SARS-CoV, DNA/RNA Synthesis, RSV, Drug Metabolite

Cat.No: T4377

Synonym: VX-787

Target: Influenza Virus

Cat.No: T9618

Target: SARS-CoV

1,5-Isoquinolinediol

Cat.No: T7042

Target: PARP

Cat.No: T16945

Synonym: Portamycin

Target: Antibacterial

Acyclovir sodium

Cat.No: T1454L

Synonym: Aciclovir sodium

Target: Others

3'-Deoxyuridine-5'-triphosphate

Cat.No: T35657

Target: Others

Cat.No: T75344

Target: Others

Cat.No: T69130

Synonym: Rubidazon ; Rubidazone,Rubidazone,Rubidazon

Target: Others

Cat.No: T70961

Target: Others

PSI-7409 tetrasodium

Cat.No: T13852

Target: Others

4'-Azidothymidine 5'-triphosphate

Cat.No: T29431

Synonym: Adrt TP,Adrt-TP,AdrtTP

Target: Others

Cat.No: T70284

Target: Others

Cat.No: T69384

Target: Others

Cat.No: T32050

Synonym: HCV 371

Target: Others

Tenofovir diphosphate triethylamine

Cat.No: T37910

Target: Others

Tenofovir diphosphate

Cat.No: T37909

Target: Others

Cidofovir diphosphate tri(triethylamine)

Cat.No: T73983

Target: Others

3'-Deoxyuridine-5'-triphosphate trisodium

Cat.No: T35658

Target: Others

Cat.No: T40359

Synonym: 6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate

Target: Others

GS-443902 trisodium

Cat.No: T38761

Synonym: GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium,瑞德西韦代谢物三钠盐

Target: Others

9(Z),11(E),13(E)-Octadecatrienoic Acid

Cat.No: T36698

Target: Others

Cat.No: T80760

Target: Influenza Virus

9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester

Cat.No: T36888

Target: Others

Methyl alpha-eleostearate

Cat.No: T36889

Target: Others

Carotenoid Mixture

Cat.No: T35983

Target: Others

2'-Deoxyadenosine-5'-triphosphate (sodium salt hydrate)

Cat.No: T37106

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7004	Tubercidin 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine	Influenza Virus; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Tubercidin (Sparsomycin A) 是从Streptomyces tubercidicus 得到的抗生素，抑制粪链球菌生长的IC50值为 0.02 μM。它是腺苷磷酸化酶的弱抑制剂，并干扰腺苷和 AMP 的磷酸化。它有抗病毒作用。
TN2286	Tsugaric acid A	NO Synthase	Immunology/Inflammation
	Tsugaric acid A 能够显著抑制超氧阴离子的形成，还可以保护人类角质形成细胞，使其免受紫外线 B 诱导的损害。
T5255	5-Hydroxymethyluracil 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine	Others; Endogenous Metabolite	Metabolism; Others
	5-(Hydroxymethyl)uracil 是一种氧化性 DNA 损伤的产物，能够增强或抑制细菌 RNA 聚合酶转录的潜在表观遗传标记。
T4010	Juglone 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin	DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料，有抗菌作用。

天然产物

Cat.No: T7004

Synonym: 结核菌素,杀结核菌素,Sparsomycin A,7-Deazaadenosine

Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic

Tsugaric acid A

Cat.No: TN2286

Target: NO Synthase

5-Hydroxymethyluracil

Cat.No: T5255

Synonym: 5-(Hydroxymethyl)uracil,5-羟甲基脲嘧啶,Hydroxymethyl Uracil,a-Hydroxythymine

Target: Others, Endogenous Metabolite

Cat.No: T4010

Synonym: 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin

Target: DNA/RNA Synthesis, Antibacterial

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02380	RPB5 Protein, Kluyveromyces marxianus, Recombinant (His) RPB5,DNA-directed RNA polymerases I, II, and III su...	Kluyveromyces marxianus	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol...
TMPJ-00792	DNA PolymeraseBeta Protein, Human, Recombinant (His) DNA Polymeraseβ,POLB,DNA Polymerase Beta,DNA Polymerase β	Human	E. coli
	Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a proce...
TMPH-01237	POLQ Protein, Human, Recombinant (E. coli, His) DNA polymerase eta,POLQ,DNA polymerase theta	Human	E. coli
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-01238	POLQ Protein, Human, Recombinant (His) DNA polymerase eta,POLQ,DNA polymerase theta	Human	Baculovirus Insect Cells
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...

重组蛋白

RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)

Cat.No: TMPH-02380

Species: Kluyveromyces marxianus

Expression System: E. coli

DNA PolymeraseBeta Protein, Human, Recombinant (His)

Cat.No: TMPJ-00792

Species: Human

Expression System: E. coli

POLQ Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01237

Species: Human

Expression System: E. coli

POLQ Protein, Human, Recombinant (His)

Cat.No: TMPH-01238

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T38297	Ribavirin-13C5 Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

同位素标记化合物

Cat.No: T38297

Synonym: Ribavirin-13C5

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