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Search Results for " peripheral nervous system "

Targets Recommended: Adrenergic Receptor

24

抑制剂 & 化合物

2

天然产物

2

化合物库

15

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L2630	神经元分化化合物库		672 compounds
	672 种与神经元分化相关的化合物，可以用于神经系统疾病药物研发
L2800	5-羟色胺分子库		268 compounds
	268 种生物活性小分子化合物，用于高通量、高内涵筛选；

化合物库

神经元分化化合物库

Cat.No: L2630

Compounds: 672

5-羟色胺分子库

Cat.No: L2800

Compounds: 268

Cat. No.	Product Name	Target	Signaling Pathways
T6579	Medetomidine hydrochloride MPV785,Medetomidine HCl,Domitor	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Medetomidine hydrochloride (MPV785) 是一种 α2 肾上腺素受体激动剂，能够作用于α2和α1肾上腺素受体，其Ki 分别为1.08 nM 和1750 nM。
T7748	Dermorphin TFA 皮啡肽三氟乙酸盐	Others; Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others
	Dermorphin TFA 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。
T7404	Dermorphin 皮啡肽	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Dermorphin 是在两栖类皮肤中发现的天然七肽，是 μ-阿片受体激动剂，可用于抑制神经痛。
T7656	Apelin-13
	Apelin-13 是存在于中枢和外周神经系统由13个氨基酸组成的多肽序列，是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体，对 APJ 的 EC50 值为 0.37 nM。Apelin-13 具有扩张血管和降压活性，可用于研究 2 型糖尿病综合征。
T2525	Alosetron hydrochloride Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X	5-HT Receptor	GPCR/G Protein; Neuroscience
	Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂，可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应，具有抗炎活性，用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50约为 55 nM。
T3354	BIA 10-2474 BIA10-2474	FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	BIA 10-2474 是一种长效可逆的脂肪酸酰胺水解酶抑制剂，与人类内源性大麻素系统相互作用，可增加中枢神经系统和外周组织，对大鼠大脑不同区域的 IC50值为50至70mg/kg。它用于治疗焦虑症、帕金森氏病和多发性硬化症、高血压或肥胖症的慢性疼痛。
T68095	Losulazine	Dopamine Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Losulazine 是一种新型的降压化合物。其确切的作用机制尚未确定，但其降压作用取决于完整的、功能性交感神经系统的存在。
T27179	Diniprofylline Coreverum	Others	Others
	Diniprofylline, a phosphodiesterase inhibitor, has been used as a peripheral nervous system agent, a bronchodilator agent, and an anti-asthamtic agent.
T11323L	Frakefamide	Others	Others
	Frakefamide is a potent analgesic. It acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system.
T68937	Carbidopa hydrochloride	Others	Others
	Carbidopa hydrochloride is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa. This property is significant in that it allows a greater proportion of peripheral levodopa to cross the blood–brain barrier for central nervous system effect.
T11323	Frakefamide TFA (188196-22-7 free base) Frakefamide TFA	Others	Others
	Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system. Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist.
T84442	MCHB-1 N-Methylcyclohexyl benzimidazole analog 1	Others	Others
	MCHB-1, a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50= 0.52 nM), demonstrates high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively), distinguishing itself from similar benzimidazole compounds that significantly alleviate peripheral pain while minimizing central nervous system side effects in mice.
T75788	α-CGRP(human) TFA
	α-CGRP(human) TFA，一种含37个氨基酸的调节性神经肽，广泛存在于中枢神经系统和周围神经系统中，是一种高效的血管扩张剂。
T82403	Fibronectin Type III Connecting Segment Fragment 1-25
	Fibronectin Type III Connecting Segment Fragment 1-25，一种多肽，主要作用于黑色素瘤细胞的粘附，并在鸡的周围神经系统发育中扮演关键角色。
T73655	Frakefamide TFA	Others	Others
	Frakefamide TFA 是一种有效的止痛药物，作为μ 受体的选择性外围激动剂。该化合物不能穿透血脑屏障，因此不进入中枢神经系统。
TP1681	Neuropeptide Y (22-36)
	Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y.Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. N
T37715	Galactosylcerebrosides (bovine)
	Galactosylcerebrosides (SGal-CB) 在髓鞘形成的早期阶段可由周围神经系统 (PNS) 中的 Schwann 细胞 (SC) 表达，在鞘中的持续存在对于长期维持其结构完整性至关重要。
T71955	C3001a	Others	Others
	C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous system to reduce the excitability of nociceptive neurons. In neuropathic pain, C3001a alleviated spontaneous pain and cold hyperalgesia. In a mouse model of acute pancreatitis, C3001a alleviated mechanical allodynia and inflammation. C3001a represents a lead compound which could a...
T71425	Noberastine maleate	Others	Others
	Noberastine maleate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack centra...
T70773	Noberastine citrate	Others	Others
	Noberastine citrate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack centra...
T76285	β-Endorphin (6-31), human β-EP (6-31), human	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	β-Endorphin是一种内源性阿片类神经肽，作为opioid receptor激动剂，主要与μ-阿片受体发生作用。该肽在中枢和周围神经系统特定神经元中表达，是人类体内三种内啡肽之一。β-Endorphin在减轻压力、维护生理平衡及调控神经系统的疼痛感知中发挥作用。
T78282	Tanezumab RN-624,PF 4383119
	Tanezumab (RN-624) 是一种针对神经生长因子（NGF）的人源化单克隆抗体，具有高度的亲和力和特异性，它通过阻断NGF与p75和TrkA受体的结合来发挥作用，这些受体存在于周围神经系统中。Tanezumab 主要用于研究治疗各种急性及慢性疼痛症状，包括骨关节炎、膝关节炎、神经痛以及带状疱疹后神经痛。
T70097	Acefylline piperazine	Others	Others
	Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula...
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit...

化合物

Medetomidine hydrochloride

Cat.No: T6579

Synonym: MPV785,Medetomidine HCl,Domitor

Target: Adrenergic Receptor

Cat.No: T7748

Synonym: 皮啡肽三氟乙酸盐

Target: Others, Opioid Receptor

Cat.No: T7404

Synonym: 皮啡肽

Target: Opioid Receptor

Cat.No: T7656

Alosetron hydrochloride

Cat.No: T2525

Synonym: Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X

Target: 5-HT Receptor

Cat.No: T3354

Synonym: BIA10-2474

Target: FAAH, Autophagy

Cat.No: T68095

Target: Dopamine Receptor, Norepinephrine

Cat.No: T27179

Synonym: Coreverum

Target: Others

Cat.No: T11323L

Target: Others

Carbidopa hydrochloride

Cat.No: T68937

Target: Others

Frakefamide TFA (188196-22-7 free base)

Cat.No: T11323

Synonym: Frakefamide TFA

Target: Others

Cat.No: T84442

Synonym: N-Methylcyclohexyl benzimidazole analog 1

Target: Others

α-CGRP(human) TFA

Cat.No: T75788

Fibronectin Type III Connecting Segment Fragment 1-25

Cat.No: T82403

Frakefamide TFA

Cat.No: T73655

Target: Others

Neuropeptide Y (22-36)

Cat.No: TP1681

Galactosylcerebrosides (bovine)

Cat.No: T37715

Cat.No: T71955

Target: Others

Noberastine maleate

Cat.No: T71425

Target: Others

Noberastine citrate

Cat.No: T70773

Target: Others

β-Endorphin (6-31), human

Cat.No: T76285

Synonym: β-EP (6-31), human

Target: Opioid Receptor

Cat.No: T78282

Synonym: RN-624,PF 4383119

Acefylline piperazine

Cat.No: T70097

Target: Others

Sulfatides (bovine) (sodium salt)

Cat.No: T35639

Cat. No.	Product Name	Target	Signaling Pathways
TN2322	Yangambin	Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素，是选择性PAF 受体拮抗剂，通过调控Ca2+通道抑制 Ca2+流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少，具有降压作用。
T0848	L-DOPA 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine	Dopamine Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism; Neuroscience
	L-DOPA (Levodopa) 是的神经递质多巴胺的代谢前体，具有口服活性。Levodopa 能够透过血脑屏障，并在大脑中转化为多巴胺。Levodopa 具有抗痛觉过敏作用。Levodopa 还具有帕金森氏病的研究潜力。

天然产物

Cat.No: TN2322

Target: Calcium Channel, PAFR

Cat.No: T0848

Synonym: 左旋多巴,Levodopa,3,4-Dihydroxyphenylalanine

Target: Dopamine Receptor, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01065	Noggin/NOG Protein, Mouse, Recombinant (His) Nog,Noggin	Mouse	HEK293 Cells
	Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affi...
TMPH-02489	ASCL2 Protein, Mouse, Recombinant (His & Myc) mASH2,Achaete-scute homolog 2,ASH-2,mASH-2,Ascl2,Mash2	Mouse	E. coli
	AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. ASCL2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.8 kDa and the accession number is O35885.
TMPH-03350	Pmp22 Protein, Rat, Recombinant (His) Peripheral myelin protein 22,Schwann cell membrane ...	Rat	E. coli
	Might be involved in growth regulation, and in myelinization in the peripheral nervous system. Pmp22 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 23.4 kDa and the accession number is P25094.
TMPK-01062	RGMC Protein, Mouse, Recombinant (His) HJV,DL-M,JH,Rgmc,RGM-C,Hemojuvelin,HFE2,HFE2AMGC23953	Mouse	HEK293 Cells
	RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system.
TMPY-01563	PMP2 Protein, Human, Recombinant (His) MP2,FABP8,peripheral myelin protein 2,P2,M-FABP	Human	E. coli
	Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells ...
TMPY-00561	Neurotensin Protein, Human, Recombinant (hFc) NMN-125,NTS1,NN,NT/N,neurotensin,NT	Human	HEK293 Cells
	NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali...
TMPK-01179	CDH19 Protein, Human, Recombinant (MBP & Flag) Cadherin19,Cadherin-19,CDH7L2,cad19	Human	E. coli
	Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected with catenins, forming cadherin-catenin complexes, which are crucial for cell-to-cell adherence. CDH19 is an evolutionarily conserved cadherin and may be involved in the early development of Schwann cells in the peripheral nervous system.
TMPY-00286	Neuropeptide Y Protein, Human, Recombinant (hFc) PYY4,neuropeptide Y	Human	HEK293 Cells
	NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY is a neuromodulator that is widely expressed throughout the central nervous system (CNS) and is consecrated with classic neurotransmitters including GABA and glutamate. NPY/Agouti-related protein (AgRP) ne...
TMPJ-00913	MPZ Protein, Human, Recombinant (His) Myelin Peripheral Protein,Myelin Protein P0,MPZ,Mye...	Human	HEK293 Cells
	Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ is a major component of the myelin sheath in peripheral nerves. It is postulated that MPZ is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively-charged domain...
TMPJ-00706	SNCG Protein, Human, Recombinant PRSN,Gamma-Synuclein,SNCG,BCSG1,Breast Cancer-Specific Gene ...	Human	E. coli
	Gamma-Synuclein (SNCG) is a member of the Synuclein protein family. Gamma-Synuclein is mostly expressed in the peripheral nervous system and retina. Gamma-Synuclein plays a role in neurofilament network integrity and may be involved in modulating axonal architecture during development and in the adult. In addition, it may also function in modulating the keratin network in skin. SNCG expression in breast tumors has been as a marker for tumor progression. SNCG is also believed to be involved in th...
TMPJ-00114	EFNA3 Protein, Mouse, Recombinant (hFc) EFL2,LERK-3,EFNA3,Ephrin-A3,EHK1-L,EPLG3,EFL-2,EHK1 Ligand,L...	Mouse	HEK293 Cells
	Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhe...
TMPJ-00983	ARRB1 Protein, Human, Recombinant (His) Arrestin β-1,β-Arrestin-1,Beta-Arrestin-1,ARR1,ARRB1,Arresti...	Human	E. coli
	β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in r...
TMPJ-00100	Artemin Protein, Human, Recombinant ARTN,Artemin,EVN,Enovin,Neublastin	Human	E. coli
	Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...
TMPY-00681	BMP-5 Protein, Human, Recombinant (hFc) bone morphogenetic protein 5	Human	HEK293 Cells
	Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily. In agreement with a possible role in the control of cell death, BMP-5 exhibited a regulated pattern of expression in the interdigital tissue. Transcripts of BMP-5 and BMP-5 protein were abundant within the cytoplasm of the fragmenting apoptotic interdigital cells in a way sugges...
TMPY-04566	CAMKV Protein, Human, Recombinant (His & GST) 1G5,VACAMKL,CaM kinase-like vesicle-associated	Human	Baculovirus Insect Cells
	CaM kinase-like vesicle-associated protein, also known as CAMKV, is a peripheral membrane protein and Cytoplasmic vesicle membrane protein which belongs to theprotein kinase superfamily and CAMK Ser/Thr protein kinase family. CAMKV contains oneprotein kinase domain. It is predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. CAMKV may be associated with vesicular structures. It does not appear to have detectable kinase activity. ...

重组蛋白

Noggin/NOG Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01065

Species: Mouse

Expression System: HEK293 Cells

ASCL2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02489

Species: Mouse

Expression System: E. coli

Pmp22 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03350

Species: Rat

Expression System: E. coli

RGMC Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01062

Species: Mouse

Expression System: HEK293 Cells

PMP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01563

Species: Human

Expression System: E. coli

Neurotensin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00561

Species: Human

Expression System: HEK293 Cells

CDH19 Protein, Human, Recombinant (MBP & Flag)

Cat.No: TMPK-01179

Species: Human

Expression System: E. coli

Neuropeptide Y Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00286

Species: Human

Expression System: HEK293 Cells

MPZ Protein, Human, Recombinant (His)

Cat.No: TMPJ-00913

Species: Human

Expression System: HEK293 Cells

SNCG Protein, Human, Recombinant

Cat.No: TMPJ-00706

Species: Human

Expression System: E. coli

EFNA3 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00114

Species: Mouse

Expression System: HEK293 Cells

ARRB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00983

Species: Human

Expression System: E. coli

Artemin Protein, Human, Recombinant

Cat.No: TMPJ-00100

Species: Human

Expression System: E. coli

BMP-5 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00681

Species: Human

Expression System: HEK293 Cells

CAMKV Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04566

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0312	L-Dopa-2,5,6-d3
	L-Dopa-2,5,6-d3 是 L-Dopa 的氘代化合物。L-Dopa 的 CAS 号为 59-92-7。Levodopa 是的神经递质多巴胺的代谢前体，具有口服活性。Levodopa 能够透过血脑屏障，并在大脑中转化为多巴胺。Levodopa具有抗痛觉过敏作用。Levodopa还具有帕金森氏病的研究潜力。

同位素标记化合物

L-Dopa-2,5,6-d3

Cat.No: TMIJ-0312

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