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Search Results for " m 15 "
Targets Recommended: Others

32

抑制剂 & 化合物

3

天然产物

4

重组蛋白

2

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T21007 m 15

5COB,5OCB,D 105

Others Others
M 15 liquid crystals are a member of the oxycyanobiphenyl family, which exhibits a liquid crystalline phase in the temperature range of 47-67.5℃.
T71297 TT15

Others Others
TT15 is an agonist of the GLP-1R.
T18149 m-PEG15-alcohol

Others Others
m-PEG15-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18150 m-PEG15-NHS ester

Others Others
m-PEG15-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T85031 C24:1 1-Deoxyceramide (m18:1/24:1(15Z))

N-tetracosenoyl-1-deoxy-4,5-dihydro-Sphingosine,C24:1(15Z) 1-Deoxyceramide,C24:1 Ceramide (m18:1/24:1(15Z)),Cer(m18:1/24:1(15Z))

Others Others
T60050 ANT3310

Antibacterial Microbiology/Virology
ANT3310 是一种广谱共价丝氨酸 β-内酰胺酶抑制剂,对 AmpC、CTX-M-15、TEM-1、OXA-48、OXA-23 和 KPC-2 的 IC50 范围为 1 nM 至 175 nM。 ANT3310 可用于细菌感染研究。
T38941 FPI-1523 sodium

Endogenous Metabolite; Antibacterial Metabolism; Microbiology/Virology
FPI-1523 sodium 是阿维巴坦的衍生物,是一种强效的 β-内酰胺酶抑制剂,对 CTX-M-15 和 OXA-48 的 K d s 分别为 4 nM 和 34 nM。FPI-1523 sodium 对 PBP2 有抑制作用,其 IC 50 为 3.2 μM。FPI-1523 sodium具有相当高的抗菌活性。
T10422 Avibactam free acid

NXL-104 free acid

Antibacterial Microbiology/Virology
Avibactam (NXL-104) free acid is a covalent and reversible inhibitor of non-β-lactam β-lactamase (IC50s: 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15).
T60945 Antitubercular agent-15

Others Others
Antitubercular agent-15 (Compound 5n) 是一种抗结核剂, 对肺成纤维细胞和巨噬细胞具有低细胞毒性。Antitubercular agent-15 对结核分枝杆菌 H37Rv、CF16、CF61、CF76、CF152 和 CF161 的 MIC90值分别为 0.73、7.69、9.38、18.80、7.53 和 7.31 μg/mL。
T60874 Avibactam sodium dihydrate

Others Others
Avibactam sodium (NXL-104) dihydrate 抑制 CTX-M-15和 β-内酰胺酶 TEM-1,IC50值分别为 5 nM 和 8 nM。Avibactam sodium (NXL-104) dihydrate 是非 β-内酰胺 β-内酰胺酶的可逆共价抑制剂。
T38940 FPI-1523

Others Others
FPI-1523, a derivative of Avibactam, is a potent inhibitor of β-lactamase enzymes. It has Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. Additionally, FPI-1523 inhibits PBP2 with an IC50 of 3.2 μM and demonstrates significant antimicrobial activity.
T60711 Avibactam sodium hydrate

Others Others
Avibactam sodium hydrate (NXL-104 hydrate) 是 β-内酰胺酶的共价可逆抑制剂,不含β-内酰胺核心 。Avibactam sodium hydrate 抑制 β-内酰胺酶CTX-M-15和TEM-1,IC50分别为5 nM 和 8 nM。
T61023 Antitubercular agent-21

Others Others
Antitubercular agent-21 (Compound 15) 是具有低细胞毒性的抗结核剂。Antitubercular agent-21 对 M. tuberculosisH37Rv 的 MIC 值为 0.4 μg/mL。然而,Antitubercular agent-21 对其他微生物,如革兰氏阳性菌、革兰氏阴性菌或真菌,表现出较低的生物活性。
T61204 FPI-1465

Others Others
FPI-1465 是丝氨酸-β-内酰胺酶和青霉素结合蛋白 (PBP) 的双重抑制剂。FPI-1465 抑制PBP2,IC50为 1.0 μg/mL。FPI-1465 作用于 β-内酰胺酶 CTX-M-15 和 OXA-48,Kd 分别为 0.011 和 5.3 μM。
T69316 DA 3003-2

NSC663285

Others Others
DA 3003-2为一种高效的选择性Cdc25抑制剂,展示了抗增殖活性,能诱导细胞周期在G2/M期停滞,并提高P-tyr15Cdc2表达量,显示出对前列腺癌研究的应用潜力。
T70235 Cemadotin hydrochloride

Others Others
Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15, an antiproliferative compound which was isolated from the mollusk Dolabella auricularia. Like Dolastatin 15, LU103793 is highly cytotoxic in vitro (IC50 = 0.1 nM). LU103793 inhibits microtubule polymerization in a concentration-dependent manner (IC50 = 7 microM). Treatment with ...
T15158 Dolastatin 15

DLS 15

Others; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Others
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m
T84392 14-Pentadecenoic Acid

FA 15:1,ω-Pentadecenoic Acid

Others Others
14-Pentadecenoic acid, a 15-carbon long-chain fatty acid with an alkene functional group on the terminal carbon of its aliphatic tail, has been observed to undergo oxidation due to the growth of M. cerificans at the expense of the parent alkene. This compound is utilized in the creation of fibrous scaffold biomaterials for tissue engineering purposes and in constructing metallomesogenic side-chain polymers for coating capillary columns in gas chromatography applications.
T83874 S-72

Others Others
S-72是一种微管聚合抑制剂,以1, 3, 10 µM的浓度在无细胞测定中抑制微管聚合,并在MCF-7和耐紫杉醇的MCF-7/T乳腺癌细胞中降低细胞活性(IC50分别为15.64和26.32 nM)。50 nM浓度的S-72能抑制MCF-7和MCF-7/T细胞的迁移和侵袭,并减少划痕实验中的伤口闭合百分比。100 nM的S-72在MCF-7/T细胞中诱导G2/M期的细胞周期阻滞以及凋亡,并在同一浓度下抑制这些细胞中干扰素基因激活剂(STING)的激活。以每天15 mg/kg的剂量,S-72抑制了耐紫杉醇的MCF-7/T和MX-1/T小鼠异种移植模型中的肿瘤生长。
T35485 6-Prenylindole

Others Others
6-Prenylindole is a bacterial metabolite that has been found in Streptomyces and has antifungal and antimalarial properties.1 It is active against A. brassicicola strain TP-F0423 and F. oxysporum f. sp. tulipae TU-4-2 (15 and 30 μg/disc in the paper disc assay), and also drug-resistant P. falciparum strain K1 (IC50 = 21 μg/ml).2 |1. Sasaki, T., Igarashi, Y., Ogawa, M., et al. Identification of 6-prenylindole as an antifungal metabolite of Streptomyces sp. TP-A0595 and synthesis and bioactivity o...
T38309 LL-37 amide (trifluoroacetate salt)

Others Others
LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...
T36034 CAY10774

Others Others
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50= 6.6 μM in a reporter assay). CAY10774 increases surface expression of PD-1 on primary human CD4+and CD8+T cells co-cultured with aAPCs. 1.Konieczny, M., Musielak, B., Koc...
T36658 Boc-Glu-OBzl

Boc-Glu-OBzl is an amino acid building block.1,2It has been used in the synthesis of peptide-based inhibitors of human caspases and human rhinovirus (HRV) 3C protease that have enzyme inhibitory activityin vitro. 1.Garcia-Calvo, M., Peterson, E.P., Leiting, B., et al.Inhibition of human caspases by peptide-based and macromolecular inhibitorsJ. Biol. Chem.273(49)32608-32613(1998) 2.Dragovich, P.S., Webber, S.E., Babine, R.E., et al.Structure-based design, synthesis, and biological evaluation of i...
T36999 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Others Others
Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to b...
T36991 Monascuspiloin

Others Others
Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 ...
T35463 (±)14(15)-EET

(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Others Others
(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...
T36215 17R(18S)-EpETE

Others Others
17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases ...
T36132 3β-OH-7-Oxocholenic Acid

Others Others
3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 |1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick dise...
T36418 O-Desmethyl-N-deschlorobenzoyl Indomethacin

Others Others
O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T37297 Ru360

Others Others
Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce...
T35568 BODIPY-aminoacetaldehyde diethyl acetal

Others Others
BODIPY-aminoacetaldehyde diethyl acetal (BAAA-DA) is a stable precursor to BODIPY-aminoacetaldehyde, a cell-permeable fluorescent substrate for aldehyde dehydrogenase (ALDH).1,2BODIPY-aminoacetaldehyde diethyl acetal is converted under acidic conditions to BODIPY-aminoacetaldehyde (BAAA).2BAAA is cell-permeant and is converted intracellularly by ALDH to BODIPY aminoacetate (BAA), which is retained by cells and can be used to identify cells with high ALDH activity.1BAA is a substrate for the effl...
T36717 RWJ-56110 dihydrochloride

Others Others
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...

化合物

m 15
Cat.No: T21007
Synonym: 5COB,5OCB,D 105
Target: Others
TT15
Cat.No: T71297
Synonym:
Target: Others
m-PEG15-alcohol
Cat.No: T18149
Synonym:
Target: Others
m-PEG15-NHS ester
Cat.No: T18150
Synonym:
Target: Others
C24:1 1-Deoxyceramide (m18:1/24:1(15Z))
Cat.No: T85031
Synonym: N-tetracosenoyl-1-deoxy-4,5-dihydro-Sphingosine,C24:1(15Z) 1-Deoxyceramide,C24:1 Ceramide (m18:1/24:1(15Z)),Cer(m18:1/24:1(15Z))
Target: Others
ANT3310
Cat.No: T60050
Synonym:
Target: Antibacterial
FPI-1523 sodium
Cat.No: T38941
Synonym:
Target: Endogenous Metabolite, Antibacterial
Avibactam free acid
Cat.No: T10422
Synonym: NXL-104 free acid
Target: Antibacterial
Antitubercular agent-15
Cat.No: T60945
Synonym:
Target: Others
Avibactam sodium dihydrate
Cat.No: T60874
Synonym:
Target: Others
FPI-1523
Cat.No: T38940
Synonym:
Target: Others
Avibactam sodium hydrate
Cat.No: T60711
Synonym:
Target: Others
Antitubercular agent-21
Cat.No: T61023
Synonym:
Target: Others
FPI-1465
Cat.No: T61204
Synonym:
Target: Others
DA 3003-2
Cat.No: T69316
Synonym: NSC663285
Target: Others
Cemadotin hydrochloride
Cat.No: T70235
Synonym:
Target: Others
Dolastatin 15
Cat.No: T15158
Synonym: DLS 15
Target: Others, ADC Cytotoxin
14-Pentadecenoic Acid
Cat.No: T84392
Synonym: FA 15:1,ω-Pentadecenoic Acid
Target: Others
S-72
Cat.No: T83874
Synonym:
Target: Others
6-Prenylindole
Cat.No: T35485
Synonym:
Target: Others
LL-37 amide (trifluoroacetate salt)
Cat.No: T38309
Synonym:
Target: Others
CAY10774
Cat.No: T36034
Synonym:
Target: Others
Boc-Glu-OBzl
Cat.No: T36658
Synonym:
Target:
7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
Cat.No: T36999
Synonym:
Target: Others
Monascuspiloin
Cat.No: T36991
Synonym:
Target: Others
(±)14(15)-EET
Cat.No: T35463
Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
Target: Others
17R(18S)-EpETE
Cat.No: T36215
Synonym:
Target: Others
3β-OH-7-Oxocholenic Acid
Cat.No: T36132
Synonym:
Target: Others
O-Desmethyl-N-deschlorobenzoyl Indomethacin
Cat.No: T36418
Synonym:
Target: Others
Ru360
Cat.No: T37297
Synonym:
Target: Others
BODIPY-aminoacetaldehyde diethyl acetal
Cat.No: T35568
Synonym:
Target: Others
RWJ-56110 dihydrochloride
Cat.No: T36717
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T36815 Chevalone C

Others Others
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.
T37272 9(S),12(S),13(S)-TriHOME

Others Others
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
T36563 (E)-Guggulsterone

Others Others
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Chevalone C
Cat.No: T36815
Synonym:
Target: Others
9(S),12(S),13(S)-TriHOME
Cat.No: T37272
Synonym:
Target: Others
(E)-Guggulsterone
Cat.No: T36563
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPK-01412 HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

SARS-CoV-2 epitope,MHC

Human HEK293 Cells
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01416 HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

MHC,SARS-CoV-2 epitope

Human HEK293 Cells
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPY-00803 Fibronectin Protein, Human, Recombinant (aa 607-1265, His)

GFND,LETS,ED-B,fibronectin 1,CIG,GFND2,FNZ,FINC,FN,MSF

Human HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 607-1265, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 73.2 kDa and the accession number is P02751-15.
TMPY-05562 Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)

fibronectin 1,ED-B,CIG,FNZ,MSF,FN,FINC,GFND,LETS,GFND2

Human HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 11.3 kDa and the accession number is P02751-15.

重组蛋白

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01412
Species: Human
Expression System: HEK293 Cells
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01416
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 607-1265, His)
Cat.No: TMPY-00803
Species: Human
Expression System: HEK293 Cells
Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)
Cat.No: TMPY-05562
Species: Human
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMIJ-0295 Flubendazole-d3 (methyl-d3)

Flubendazole-d3 (methyl-d3) 是 Flubendazole 的氘代化合物。Flubendazole 的 CAS 号为 31430-15-6。Flubendazole 是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡,抑制 G2/M 细胞周期。
T37847 Zonisamide-13C2,15N

Zonisamide-13C2,15N

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Flubendazole-d3 (methyl-d3)
Cat.No: TMIJ-0295
Synonym:
Target:
Zonisamide-13C2,15N
Cat.No: T37847
Synonym: Zonisamide-13C2,15N
Target:
TargetMol Loading
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