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Targets Recommended: Apoptosis Endogenous Metabolite Prostaglandin Receptor Autophagy PROTAC Linker

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4546	Dinoprost tromethamine salt Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM	Apoptosis; Endogenous Metabolite; Prostaglandin Receptor; Autophagy; PROTAC Linker	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; PROTAC
	Dinoprost tromethamine salt (PGF2α THAM) 是一种口服有效的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素，在分娩过程中起关键作用。
T36146	13,14-dihydro Prostaglandin F2α 13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α	Others	Others
	13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value for 13,14-dihydro PGF2α as a luteolytic agent in hamsters is 1.5 &#181g/100 g.[1]
T37231	(+)-Cloprostenol methyl ester	Others	Others
	(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprosteno...
T37813	Fluprostenol methyl ester	Others	Others
	Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY10532 is a methyl ester analog of fluprostenol.
T37938	17-phenoxy trinor Prostaglandin F2α ethyl amide 17-phenoxy trinor Prostaglandin F2α ethyl amide	Others	Others
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2α and 16-phenoxy tetranor PGF2α are metabolically stable analogs of PGF2α and potent agonists for the FP receptor. 17-phenoxy trinor PGF2α ethyl amide is a lipophilic analog of 17-phenoxy trinor PGF2α . Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.
T37230	(+)-5-trans Cloprostenol	Others	Others
	Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses. (+)-5-trans Cloprostenol is a minor impurity produced in the synthesis of (+)-cloprostenol. The (+)-5-trans isomer is 20-fold less active than the 5-cis form in terminating pregnancy in the hamster.
T37947	17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester	Others	Others
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophil...
T37946	17-trifluoromethylphenyl trinor Prostaglandin F2α 17-trifluoromethylphenyl trinor Prostaglandin F2α	Others	Others
	A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trin...
T37777	17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide	Others	Others
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2α) is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoro...

化合物

Dinoprost tromethamine salt

Cat.No: T4546

Synonym: Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM

Target: Apoptosis, Endogenous Metabolite, Prostaglandin Receptor, Autophagy, PROTAC Linker

13,14-dihydro Prostaglandin F2α

Cat.No: T36146

Synonym: 13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α

Target: Others

(+)-Cloprostenol methyl ester

Cat.No: T37231

Synonym:

Target: Others

Fluprostenol methyl ester

Cat.No: T37813

Synonym:

Target: Others

17-phenoxy trinor Prostaglandin F2α ethyl amide

Cat.No: T37938

Synonym: 17-phenoxy trinor Prostaglandin F2α ethyl amide

Target: Others

(+)-5-trans Cloprostenol

Cat.No: T37230

Synonym:

Target: Others

17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Cat.No: T37947

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Target: Others

17-trifluoromethylphenyl trinor Prostaglandin F2α

Cat.No: T37946

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α

Target: Others

17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide

Cat.No: T37777

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15133	Dinoprost Prostaglandin F2a,PGF2α,地诺前列素	Endogenous Metabolite	Metabolism
	Dinoprost (Prostaglandin F2a) 是口服有效的、内源性的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素。它在分娩过程中起关键作用。

天然产物

Dinoprost

Cat.No: T15133

Synonym: Prostaglandin F2a,PGF2α,地诺前列素

Target: Endogenous Metabolite

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