ihmtpi3kδ372

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

Cathepsin K inhibitor3 是一种高选择性的cathepsin K 抑制剂，其IC50值为 0.5 nM。Cathepsin K inhibitor3 具有良好的药代动力学特征，可用于骨关节炎 (OA) 疾病的研究。

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

K 259-3 是 K 259-2 的甲酯，是钙调素依赖性环核苷酸磷酸二酯酶的抑制剂。

IHMT-PI3Kδ-372 是一种选择性的 PI3Kδ 抑制剂，IC50 为 14 nM，可用于慢性阻塞性肺病的研究。