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Search Results for " necroptotic "

Targets Recommended: MLK VEGFR

3

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11520	GW806742X	MLK; VEGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	GW806742X 是ATP 模拟物，是MLKL 抑制剂，可结合 MLKL 假激酶结构域，Kd 值为 9.3μM。它对VEGFR2的IC50为 2 nM，延缓 MLKL 膜移位并抑制坏死。
T73382	SZM-1209	RIP kinase	Apoptosis; NF-κB
	SZM-1209是一种口服活性且特异性RIPK1抑制剂，具有85 nM的Kd值。该化合物展现出对抗坏死性凋亡（necroptosis）高效活性（EC50=22.4 ± 8.1 nM），并能抵抗SIRS（全身炎症反应综合征）及ALI（急性肺损伤）。
T60316	AV123	Others	Others
	AV123 (化合物 12) 是一种无细胞毒性的RIPK1抑制剂，IC50值为12.12 μM。AV123 阻断 TNF-α 诱导的坏死性细胞死亡，EC50值为1.7 μM，但不阻断凋亡性细胞的死亡。AV123 可用于脑、心和肾的缺血再灌注损伤等慢性坏死性病症、炎症性疾病、神经退行性疾病和感染性疾病的研究。

化合物

Cat.No: T11520

Target: MLK, VEGFR

Cat.No: T73382

Target: RIP kinase

Cat.No: T60316

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00749	PGLYRP1 Protein, Mouse, Recombinant (hFc) PGRPSMGC126896,TNFSF3L,PGLYRP1,TAG7,PGLYRP,PGRP,PGRP-SMGC126...	Mouse	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.7 kDa and the accessio...
TMPK-00745	PGLYRP1 Protein, Human, Recombinant (hFc) PGLYRP1,TAG7,PGLYRP,PGRP-SMGC126894,PGRP,Tasg7,TNFSF3L,PGRP-...	Human	HEK293 Cells
	Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. PGLYRP1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.2 kDa and the accessio...
TMPH-01694	MLKL Protein, Human, Recombinant (E. coli, His) MLKL,Mixed lineage kinase domain-like protein	Human	E. coli
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB...

重组蛋白

PGLYRP1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00749

Species: Mouse

Expression System: HEK293 Cells

PGLYRP1 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00745

Species: Human

Expression System: HEK293 Cells

MLKL Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01694

Species: Human

Expression System: E. coli

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