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Search Results for " mineral "

Targets Recommended: Others

18

抑制剂 & 化合物

4

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4512	Magnesium glycinate magnesium 2-aminoacetate,Magnesium diglycinate,甘氨酸镁	Others	Others
	Magnesium glycinate (magnesium 2-aminoacetate) 是一种营养补充剂，是甘氨酸的镁盐，具有良好的理化性质和生物活性。Magnesium 是人体必需的矿物质，参与能量代谢过程，协助维持正常的肌肉功能，对人体起着至关重要的作用。
T21460	Teriparatide acetate hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽	Others	Others
	Teriparatide acetate (Forteo) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢（即骨骼生长）剂，用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞，从而导致骨骼整体增加。
T19986	Molybdenum disulfide Moly Powder B,Molykote Microsize Powder,T-Powder,Molysulfide,Natural molybdenite	Others	Others
	Molybdenum disulfide is the inorganic compound with the formula MoS2. Molybdenum disulfide is insoluble in water and dilutes acids. This black crystalline sulfide of molybdenum occurs as the mineral molybdenite.
T16558	Polidocanol Polyoxyethylene lauryl ether,Polyoxyethyleneglycol Dodecyl Ether	Others	Others
	Polidocanol (Polyoxyethylene lauryl ether) 是月桂醇的烷基聚乙二醇醚，是天然矿物油中天然脂肪醇或烷基醇的衍生物，是一种硬化剂。Polidocanol 可用做局部麻醉，但与其他麻醉药物合用时有增强麻醉药物对心血管系统作用的风险。
T2134	Dorzolamide hydrochloride MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl	Carbonic Anhydrase	Metabolism
	Dorzolamide hydrochloride (MK507 hydrochloride) 是一种碳酸酐酶carbonic anhydrase II 抑制剂，能够抑制红细胞CA-II(IC50:0.18 nM) 和CA-I(IC50:600 nM) 。
T26041	Ranelic acid	Others	Others
	Ranelic acid is an organic acid capable of chelating metal cations. Strontium ranelate, the strontium salt of Ranelic acid, is utilized to treat osteoporosis and increase bone mineral density.
TP1779	C-telopeptide
	C-telopeptide, a cross-linked peptide derived from type I collagen, is liberated through bone resorption and has demonstrated a correlation with bone mineral density (BMD).
T32115	Hydrogenated didecene 1-Decene,dimers,Dec-1-ene,hydrogenated,dimer	Others	Others
	Hydrogenated didecene as skin-softening agent derived from didecene, which is a hydrocarbon. Hydrocarbons are organic compounds that contain only carbon and hydrogen. Examples of common hydrocarbons include mineral oil, petroleum, and paraffin wax.
T40564	Neoabietic acid	Others	Others
	Neoabietic acid is an abietic-type acid isolated from the oleoresin and rosin of Pinus palustris . Neoabietic acid is highly susceptible to mineral acid. Neoabietic acid has antibacterial activity in vitro.
T15206	Eldecalcitol 艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	Others	Others
	Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treatment of osteoporosis .
T19904	Wollastonite Wollastonite (Ca(SiO3))	Others	Others
	Wollastonite is an industrial mineral comprised chemically of calcium, silicon, and oxygen. It has been determined to have low biopersistence in both in vivo and in vitro studies, which probably accounts for its relative lack of toxicity. There are no ple
T82929	AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG
	AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG 促进骨化作用。该化合物适用于研究成骨缺陷或骨矿物质密度（BMD）降低相关疾病，如骨质疏松症。
T76660	pTH (1-37) (human)
	pTH (1-37) (human) 为甲状旁腺激素（PTH）的一段，能诱导cAMP产生并提升碱性磷酸酶活性，进而增强尿毒症动物的生长速度、骨钙含量及骨矿物质密度（BMD），显示出对骨质疏松症研究的应用潜力。
T79023	CaSR antagonist-1	CaSR	GPCR/G Protein
	CaSRantagonist-1为一种钙敏感受体拮抗剂，其IC50为50 nM。该化合物适用于研究骨质疏松等疾病，这些病症涉及骨骼或矿物质稳态的异常。
T69793	VEL-0230	Others	Others
	VEL-0230, also known as NC-2300, is a potent cathespin K inhibitor. VEL-0230 has dual-acting properties that both stimulates bone formation and inhibits loss. VEL-0230 is being studied preclinically for the treatment of diseases involving bone mineral disorders such as bone loss related to multiple myeloma, osteoporosis, bone metastases, and rheumatoid arthritis. Velcura Therapeutics is currently being developed by Velcura Therapeutics. Given VEL- 0230's promotion of bone formation, inhibition o...
T35676	17β-hydroxy Exemestane	Others	Others
	17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = ...
T35500	3-epi-25-hydroxy Vitamin D3 3-epi-25-hydroxy Vitamin D3	Others	Others
	3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。

化合物

Magnesium glycinate

Cat.No: T4512

Synonym: magnesium 2-aminoacetate,Magnesium diglycinate,甘氨酸镁

Target: Others

Teriparatide acetate

Cat.No: T21460

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽

Target: Others

Molybdenum disulfide

Cat.No: T19986

Synonym: Moly Powder B,Molykote Microsize Powder,T-Powder,Molysulfide,Natural molybdenite

Target: Others

Cat.No: T16558

Synonym: Polyoxyethylene lauryl ether,Polyoxyethyleneglycol Dodecyl Ether

Target: Others

Dorzolamide hydrochloride

Cat.No: T2134

Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,盐酸多佐胺,Dorzolamide HCl

Target: Carbonic Anhydrase

Cat.No: T26041

Target: Others

Cat.No: TP1779

Hydrogenated didecene

Cat.No: T32115

Synonym: 1-Decene,dimers,Dec-1-ene,hydrogenated,dimer

Target: Others

Neoabietic acid

Cat.No: T40564

Target: Others

Cat.No: T15206

Synonym: 艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target: Others

Cat.No: T19904

Synonym: Wollastonite (Ca(SiO3))

Target: Others

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG

Cat.No: T82929

pTH (1-37) (human)

Cat.No: T76660

CaSR antagonist-1

Cat.No: T79023

Target: CaSR

Cat.No: T69793

Target: Others

17β-hydroxy Exemestane

Cat.No: T35676

Target: Others

3-epi-25-hydroxy Vitamin D3

Cat.No: T35500

Synonym: 3-epi-25-hydroxy Vitamin D3

Target: Others

Cat.No: T83848

Cat. No.	Product Name	Target	Signaling Pathways
TN6925	Pristane 姥鲛烷,2,6,10,14-tetramethylpentadecane	Others	Others
	Pristane (2,6,10,14-tetramethylpentadecane) 是一种天然存在的烃油，是矿物油中最活跃的成分，较少存在于许多植物、各种海洋生物中。它是一种非抗原性佐剂，可诱导大鼠中 MHC II 类限制性关节炎 T 细胞。
T2O2707	D-(+)-Fucose	Others	Others
	D-(+)-Fucose 是一种 l-阿拉伯糖的非代谢类似物，也是 β-甲基半乳糖苷透皮酶诱导剂。它能够抑制 l-阿拉伯糖操纵子的诱导，阻断大肠杆菌 B/r 在矿物盐培养基上加 l-阿拉伯糖的生长。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
T6491	(-)-(S)-Equol (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。

天然产物

Cat.No: TN6925

Synonym: 姥鲛烷,2,6,10,14-tetramethylpentadecane

Target: Others

Cat.No: T2O2707

Target: Others

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Cat.No: T6491

Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02997	Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO) Neutrophil-activating protein A,NAP A,HP-NAP,Bacterioferriti...	Mycobacterium smegmatis	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage. Dps Protein, Mycobacterium sme...
TMPK-01095	MEPE Protein, Mouse, Recombinant (His) Osteoregulin,MEPE,OF45	Mouse	HEK293 Cells
	Matrix extracellular phosphoglycoprotein (MEPE) is expressed in bone and teeth where it has multiple functions. The C-terminus of MEPE contains a mineral-binding, acidic serine- and aspartate-rich motif (ASARM) that is also present in other noncollagenous proteins of mineralized tissues.MEPE-derived ASARM peptides function in phosphate homeostasis and direct inhibition of bone mineralization in a phosphorylation-dependent manner.
TMPY-06623	CB2/CNR2 Protein, Human, Recombinant CB2,CB-2,CX5	Human	HEK293 Cells
	Genetic variants within the CNR2 gene encoding the cannabinoid receptor CB2 are associated with osteoporosis and low bone mineral density (BMD) in case-control studies. There is a possibility that genetic variants of the CNR1 gene may produce a liability to the complication of psychotic state after abuse of methamphetamine.
TMPH-00794	Dps Protein, Helicobacter pylori, Recombinant (His & SUMO) napA,DNA protection during starvation protein,Bacterioferrit...	Helicobacter pylori	E. coli
	Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role...
TMPH-02661	Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His) Fxn,Frataxin, mitochondrial	Mouse	E. coli
	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit...
TMPH-02660	Frataxin/FXN Protein, Mouse, Recombinant (His) Fxn,Frataxin, mitochondrial	Mouse	P. pastoris (Yeast)
	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activit...
TMPY-01900	Kallikrein 4/KLK4 Protein, Human, Recombinant (His) PSTS,kallikrein,kallikrein-related peptidase 4,EMSP,EMSP1,AR...	Human	HEK293 Cells
	Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transi...

重组蛋白

Dps Protein, Mycobacterium smegmatis, Recombinant (His & SUMO)

Cat.No: TMPH-02997

Species: Mycobacterium smegmatis

Expression System: E. coli

MEPE Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01095

Species: Mouse

Expression System: HEK293 Cells

CB2/CNR2 Protein, Human, Recombinant

Cat.No: TMPY-06623

Species: Human

Expression System: HEK293 Cells

Dps Protein, Helicobacter pylori, Recombinant (His & SUMO)

Cat.No: TMPH-00794

Species: Helicobacter pylori

Expression System: E. coli

Frataxin/FXN Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02661

Species: Mouse

Expression System: E. coli

Frataxin/FXN Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02660

Species: Mouse

Expression System: P. pastoris (Yeast)

Kallikrein 4/KLK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01900

Species: Human

Expression System: HEK293 Cells

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