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Search Results for " luminal "

Targets Recommended: Parasite

14

抑制剂 & 化合物

1

天然产物

1

化合物库

9

重组蛋白

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Cat. No.	Product Name
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Target	Signaling Pathways
T31482	Diloxanide Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特	Parasite	Microbiology/Virology
	Diloxanide (RD3803) 是一种抗原虫制剂，可研究组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病。它是一种活性的鲁米那抗阿米巴试剂，是由其前药二氯尼特糠酸酯在胃肠道中水解得来的。
T4546	Dinoprost tromethamine salt Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM	Apoptosis; Endogenous Metabolite; Prostaglandin Receptor; Autophagy; PROTAC Linker	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; PROTAC
	Dinoprost tromethamine salt (PGF2α THAM) 是一种口服有效的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素，在分娩过程中起关键作用。
T64352	Tiliquinol NSC 130828	Others	Others
	Tiliquinol (NSC-130828) 是一种与tibroquinol经常联用、具有抗阿米巴特性的非吸收性腔内药物，通常用于研究和调查阿米巴性肝脓肿。
T3161L	BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base)	BACE	Neuroscience
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶，属于蛋白酶家族，由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T15131	Diloxanide furoate	Others	Others
	Diloxanide furoate is a luminal amebicide used in the treatment of Amebiasis. Amebiasis is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers.
T69287	NAA-004	Others	Others
	NAA-004, also known as APAZA, has been shown to significantly inhibit toxin A-induced myeloperoxidase activity, luminal fluid accumulation, and structural damage to the colon in instances of toxin A-induced colitis.
T36366	Rhod-5N (potassium salt)
	Rhod-5N is a low affinity fluorescent calcium probe (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-5N has excitation/emission maxima of approximately 551 and 576 nm, respectively
T36389	Rhod-FF (potassium salt)
	Rhod-FF is a difluorinated analog of the cell-impermeant calcium indicator rhod-2. It has a very low affinity for calcium (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-FF has excitation/emission maxima of approximately 552 and 580 nm, respectively.
T37320	Rhod-FF AM
	Rhod-FF AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-FF . As rhod-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-FF. Rhod-FF is a difluorinated analog of the cell-impermeant calcium indicator rhod-2. It has a very low affinity for calcium (Kd = 320 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes...
T37318	Fluo-3FF (potassium salt)
	Fluo-3FF is a fluorescent calcium indicator. It is a di-fluorinated analog of Fluo-3 that displays about a 100-fold lower affinity than Fluo-3 for calcium (Kds = 42 and 0.4 μM, respectively). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Fluo-3FF has excitation/emission maxima of approximately 506 and 526 nm, respectively.
T36388	Rhod-5N AM
	Rhod-5N AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-5N . As rhod-5N AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-5N. Rhod-5N displays a low affinity for calcium (Kd = 19 μM). Low affinity calcium indicators are particularly useful for studying compartments with high concentrations of calcium, such as endoplasmic reticulum, where high affinity dyes will be insensitive to luminal fluctuations. Rhod-5N has excitation/emission m...
T36660	Olsalazine-13C6 Olsalazine-13C6	Others	Others
	Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ...
T67442	CGP-53716	Others	Others
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo...

化合物

Cat.No: T31482

Synonym: Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特

Target: Parasite

Dinoprost tromethamine salt

Cat.No: T4546

Synonym: Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM

Target: Apoptosis, Endogenous Metabolite, Prostaglandin Receptor, Autophagy, PROTAC Linker

Cat.No: T64352

Synonym: NSC 130828

Target: Others

BACE-IN-1 acetate

Cat.No: T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Diloxanide furoate

Cat.No: T15131

Target: Others

Cat.No: T69287

Target: Others

Rhod-5N (potassium salt)

Cat.No: T36366

Rhod-FF (potassium salt)

Cat.No: T36389

Cat.No: T37320

Fluo-3FF (potassium salt)

Cat.No: T37318

Cat.No: T36388

Olsalazine-13C6

Cat.No: T36660

Synonym: Olsalazine-13C6

Target: Others

Cat.No: T67442

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15133	Dinoprost Prostaglandin F2a,PGF2α,地诺前列素	Endogenous Metabolite	Metabolism
	Dinoprost (Prostaglandin F2a) 是口服有效的、内源性的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素。它在分娩过程中起关键作用。

天然产物

Cat.No: T15133

Synonym: Prostaglandin F2a,PGF2α,地诺前列素

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01636	MGAM Protein, Human, Recombinant (aa 960-1853, His) Alpha-1,4-glucosidase,Maltase-glucoamylase,MGAM	Human	Baculovirus Insect Cells
	May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
TMPK-00649	CDH6 Protein, Cynomolgus, Recombinant (His) Cadherin6,Cadherin-6,CDH6,CAD6,KCAD,K-cadherin	Cynomolgus	HEK293 Cells
	Cadherin 6 (CDH6) is an adhesion molecule localizing to the endometrial luminal epithelial cell surface in the mid-secretory/receptive phase and knockdown of CDH6 in the Ishikawa cells (receptive endometrial epithelial cell line) compromises cell integrity.
TMPH-01635	MGAM Protein, Human, Recombinant (aa 87-954, His) MGAM,Maltase-glucoamylase,Alpha-1,4-glucosidase	Human	Baculovirus Insect Cells
	May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing. MGAM Protein, Human, Recombinant (aa 87-954, His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 101.1 kDa and the accession number is O43451.
TMPJ-00691	ZG16 Protein, Human, Recombinant (His) Zymogen Granule Protein 16,ZG16,Zymogen Granule Membrane Pro...	Human	HEK293 Cells
	Zymogen Granule Membrane Protein 16 (ZG16) belongs to the jacalin lectin family. ZG16 is highly expressed in liver and is detected at lower levels in colon, ileum and jejunum. ZG16 may play a role in protein trafficking. In addition, ZG16 may act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
TMPY-02223	GSTM2 Protein, Human, Recombinant (His) GSTM2-2,GTHMUS,glutathione S-transferase mu 2 (muscle),GSTM,...	Human	E. coli
	Glutathione S-transferase Mu 2, also known as GST class-mu 2, GSTM2-2, and GSTM2, is a cytoplasm protein that belongs to the GST superfamily and Mu family. GSTM2 / GST4 contains one GST C-terminal domain and one GST N-terminal domain. The glutathione S-transferases (GSTs) are a multigene family of enzymes largely involved in the detoxification of chemicals. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, si...
TMPJ-01268	ERP27 Protein, Human, Recombinant (His) C12orf46,ER Protein 27,Endoplasmic Reticulum Resident Protei...	Human	HEK293 Cells
	Endoplasmic reticulum resident protein 27, also known as ER protein 27, C12orf46 and ERP27, is an endoplasmic reticulum luminal protein which is a member of the protein disulfide isomerase family. ERP27 contains one thioredoxin domain and does not contain a CXXC active site motif. ERP27 is widely expressed in many tissues; it has highest expression in pancreas, with lower levels in spleen, lung, kidney, thymus, and bone marrow. ERP27 interacts with PDIA3 and binds somatostatin-14 via hydrophobic...
TMPY-02050	DDOST Protein, Human, Recombinant CDG1R,OST48,OKSWcl45,AGER1,OST,dolichyl-diphosphooligosaccha...	Human	E. coli
	The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto...
TMPH-02638	HSPA5 Protein, Mouse, Recombinant (E. coli, His) Hspa5,Heat shock protein 70 family protein 5,Endoplasmic ret...	Mouse	E. coli
	Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ER...
TMPY-01996	SorCS1 Protein, Human, Recombinant (His) hSorCS,RP11-446H13.1,sortilin-related VPS10 domain containin...	Human	HEK293 Cells
	VPS1 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein that belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain. SorCS1 is a member of the Vps1p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps1p domain, which either represents the only module of the luminal/extracellular moiety or is combined...

重组蛋白

MGAM Protein, Human, Recombinant (aa 960-1853, His)

Cat.No: TMPH-01636

Species: Human

Expression System: Baculovirus Insect Cells

CDH6 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00649

Species: Cynomolgus

Expression System: HEK293 Cells

MGAM Protein, Human, Recombinant (aa 87-954, His)

Cat.No: TMPH-01635

Species: Human

Expression System: Baculovirus Insect Cells

ZG16 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00691

Species: Human

Expression System: HEK293 Cells

GSTM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02223

Species: Human

Expression System: E. coli

ERP27 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01268

Species: Human

Expression System: HEK293 Cells

DDOST Protein, Human, Recombinant

Cat.No: TMPY-02050

Species: Human

Expression System: E. coli

HSPA5 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02638

Species: Mouse

Expression System: E. coli

SorCS1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01996

Species: Human

Expression System: HEK293 Cells

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