fmoc nh peg4 ch2ch2cooh

Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptosis mechanism by degrading MCL1.This compound is unstable in powder form and other related salt forms are recommended.

Boc-NH-PEG4-CH2COOH 是一种可切割的 ADC 接头，用作抗体-药物偶联物的接头。它也是基于 PEG 的 PROTAC 接头，可用于 PROTAC 的合成。

5-Ethynyl-2'-deoxyuridine 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。它是一种胸腺嘧啶核苷类似物，在细胞增殖时能够插入正在复制的 DNA 分子中， EdU 与染料的共轭反应可以进行高效快速的细胞增殖检测分析。

1,2-Bis(2-iodoethoxy)ethane 是一种属于 PEG 类的 PROTAC linker，可用于 MT802 和 SJF620 的合成。其中 MT-802 和 SJF620 都是 PROTAC BTK 降解剂，DC50分别为 1 和 7.9 nM。

2-Phthalimidehydroxy-acetic acid 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Boc-NH-PEG8-CH2CH2COOH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Hydroxy-PEG4-(CH2)2-Boc 是一种不可切割的 ADC 接头，用于合成抗体-药物偶联物。它也可用作 PROTAC 接头用于 PROTAC 合成。.

Boc-NH-PEG12-CH2CH2COOH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Cbz-NH-PEG1-CH2CH2COOH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

PROTAC ERRα ligand 2 是雌激素相关受体 α （ERRα）反向激动剂。它对 ERRα (IC50=5.67 nM) 的抑制作用比 XCT790 (IC50=61.3 nM) 高效约 11 倍。

Fmoc-NH-PEG8-NHS ester 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

TSPO ligand-2 (Carbonic acid) 是 AUTAC1 的配体，AUTAC1含有一个对氟苄基鸟嘌呤和一个烟曲霉醇部分。

Fmoc-NH-PEG12-CH2CH2COOH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Boc-NH-PEG4-CH2CH2NH2 是一种可切割的 5 单元 PEG ADC 接头，用于合成抗体-药物偶联物。它也是一种基于 PEG 的 PROTAC 连接剂，可用于 PROTAC 的合成。

Fmoc-NH-PEG10-acid 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。

PROTACKRAS G12C degrader-2 (compound 432) 作为一种双功能化合物，主要功能是调节K-Ras蛋白的水解。该化合物一端配备了小脑细胞凋亡蛋白抑制剂 (IAP)，而另一端则含有能够与KRAS结合的片段。

Bcl-2 Bcl-xI ligands 1 作为一种Bcl-2 Bcl-xI配体，主要用于合成PROTAC Bcl-2 Bcl-xI Degrader-1。

CBP p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300 CBP.

NH2-PEG4-CH2CH2COOH is a cleavable 4-unit PEG linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Boc-NH-PEG4-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fmoc-NH-ethyl-SS-propionic acid is a cleavable linker compound utilized for the synthesis of antibody-drug conjugates (ADCs)[1].

Boc-NH-PEG24-CH2CH2COOH is a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis-Targeting Chimeras) synthesis[1].

2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a polyethylene glycol (PEG)-based linker for PROTAC synthesis [1].

Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker employed in the synthesis of PROTAC[1]. Additionally, it is utilized as a cleavable ADC linker for antibody-drug conjugates (ADC)[2].

(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based linker used for the synthesis of PROTACs[1].

Boc-NH-PEG-amine (MW 3400) serves as a PEG-based PROTAC linker and finds application in PROTAC synthesis[1].

Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEGylated PROTAC linker suitable for PROTAC synthesis[1].

Boc-NH-PEG20-CH2CH2COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Boc-NH-PEG2-CH2CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

2-Amino-1,3-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based linker utilized for PROTAC synthesis[1].

PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27) and an inhibitor of polycomb repressive complex 2 (PRC2) with a pIC50 of 8.11.

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

Fmoc-NH-PEG6-CH2CH2COOH is a cleavable linker commonly employed in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker employed in the synthesis of antibody-drug conjugates (ADCs) [1].

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate, an ADC linker, is a glutathione cleavable compound used for the attachment of monoclonal antibodies (mAb) in antibody-drug conjugates (ADCs). It specifically refers to the Alkyl-Chain composition of the linker portion of these molecules [1].

Fmoc-N-bis-PEG3-NH-Boc is a cleavable ADC linker compound consisting of three PEG units, employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-N-amido-PEG-CH2COOH (MW 5000), a PEG-based PROTAC linker, is utilized in PROTAC synthesis[1].

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker applicable for synthesizing PROTACs[1].

Methyltetrazine-PEG4-NH-Boc is a PEGylation-based linker employed for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].

Fmoc-NH-PEG1-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-N-amido-PEG4-C3-acid is a polyethylene glycol (PEG) derived linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a polyethylene glycol (PEG) derivative that serves as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].

Boc-NH-PEG10-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker utilized for PROTAC synthesis[1].

Fmoc-NH-pentanoic acid-NHS-SO3Na is a PROTAC linker molecule derived from an alkyl chain. It possesses the ability to facilitate the synthesis of PROTACs[1].