首页工具

登录

搜索结果

Search Results for " drug-drug interactions "

Targets Recommended: Apoptosis AChR

13

抑制剂 & 化合物

4

天然产物

15

化合物库

1

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L6900	稀有天然产物库		693 compounds
	693 种稀有天然产物的集合，可以用于高通量和高内涵筛选；
L7840	高溶解性卤化片段化合物库		796 compounds
	高溶解性卤化片段库包含796 个卤化片段化合物。
L7830	高溶解性片段药效团化合物库		985 compounds
	高溶解性片段药效团库包含985 个片段小分子。
VM1400	多样性核心库Part2		25920 compounds
	分子量<500，主要集中于250-450之间，方便后续的改造优化；
L7870	可溶性羧酸片段化合物库		1806 compounds
	可溶性羧酸片段库包含 1806 个化合物
L6150	天然产物共价化合物库		583 compounds
	提供产品的生物学信息和药物学信息，为筛选提供理论方向和研究基础；
L4500	抗真菌库		252 compounds
	252 个抗真菌活性化合物的独特集合，包含作用于真菌相关靶点的化合物和临床中用于真菌类疾病的药物，是相关疾病药物筛选的有效工具。
L9240	农药化合物库		270 compounds
	270种农药相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L9300	大环化合物库		210 compounds
	210 种活性已知的大环化合物，用于高通量、高内涵筛选；
L3700	JAK-STAT 化合物库		252 compounds
	252 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；
L9400	PPI抑制剂库		485 compounds
	485 种已知活性的 PPI 相关的抑制剂，可用于高通量、高内涵筛选；
DO1200	药物靶点库		53200 compounds
	数量多，含53200种小分子化合物，是高通量筛选的有力工具；
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；
DO2200	共价抑制剂库CD		12000 compounds
	数量多：超过12000种共价结合化合物，并且数量在持续增加；
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

稀有天然产物库

Cat.No: L6900

Compounds: 693

高溶解性卤化片段化合物库

Cat.No: L7840

Compounds: 796

高溶解性片段药效团化合物库

Cat.No: L7830

Compounds: 985

多样性核心库Part2

Cat.No: VM1400

Compounds: 25920

可溶性羧酸片段化合物库

Cat.No: L7870

Compounds: 1806

天然产物共价化合物库

Cat.No: L6150

Compounds: 583

Cat.No: L4500

Compounds: 252

农药化合物库

Cat.No: L9240

Compounds: 270

大环化合物库

Cat.No: L9300

Compounds: 210

JAK-STAT 化合物库

Cat.No: L3700

Compounds: 252

PPI抑制剂库

Cat.No: L9400

Compounds: 485

药物靶点库

Cat.No: DO1200

Compounds: 53200

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

共价抑制剂库CD

Cat.No: DO2200

Compounds: 12000

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
T1199	Mitotane Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦	Apoptosis; AChR	Apoptosis; Neuroscience
	Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物，可作用于肾上腺皮质癌，有抗癌活性。
T2534	Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104	Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。
T35841	5-Benzyloxygramine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂，具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体，可拮抗 5-HT 对大鼠子宫和兔耳的作用。
T68846	Coproporphyrin I dihydrochloride	Others	Others
	Coproporphyrin I dihydrochloride is an appropriate clinical biomarker to recapitulate drug-drug interactions mediated by OATP inhibition.
T61515	5-HT7 receptor ligand 1	Others	Others
	5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions with substrates of CYP3A4 or CYP2D6 enzymes [1].
T37307	Nordoxepin hydrochloride	Others	Others
	Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety of factors, including age, genetics, and drug-drug interactions.
T70391	AMG151 HCl	Others	Others
	ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse...
T62610	LY3154885	Others	Others
	LY3154885 是一种口服具有活力的多巴胺 D1 受体正变构调节剂 (PAM)。LY3154885 对药物-药物相互作用 (DDI) 的风险具有改善作用。
T37788	Resorufin benzyl ether
	Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. It is typically used near its apparent Km value of 30 μM to screen the inhibition/activation potential of test compounds, to predict potential drug-drug interactions, or to monitor other CYP450 activities. Upon enzyme cleavage, resorufin benzyl ether generates a red fluorescent product (ex. 571 nm/em. 585 nm).
T39700	Ga(III) protoporphyrin IX	Others	Others
	Ga(III)protoporphyrin-IX, a model for interporphyrin interactions in malaria pigment, possesses potent antibacterial effects against gram-negative, gram-positive, and acid-fast bacteria. It exhibits high solubility in methanol (MeOH) and serves as a malarial pigment analogue for drug development, as well as a potential antibacterial agent.
T36662	Imidafenacin Metabolite M4 Imidafenacin Metabolite M4	Others	Others
	Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007)
T35919	N-hydroxy Riluzole	Others	Others
	N-hydroxy Riluzole is a metabolite of the antiglutamatergic agent riluzole .1It is formed from riluzole predominantly by the cytochrome P450 (CYP) isoform CYP1A2 in human hepatic microsomes. 1.Sanderink, G.J., Bournique, B., Stevens, J., et al.Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitroJ. Pharmacol. Exp. Ther.282(3)1465-1472(1997)
T36794	Dolutegravir O-β-D-Glucuronide	Others	Others
	Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized by UGT1A9 in human liver and kidney microsomes and UGT1A3 in human intestinal microsomes.2,1 1.Liu, S.N., Lu, J.B., Watson, C.J.W., et al.Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitorsDrug Metab. Dispos.47(5)535-544...

化合物

Cat.No: T1199

Synonym: Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦

Target: Apoptosis, AChR

Pitavastatin calcium

Cat.No: T2534

Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104

Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy

5-Benzyloxygramine

Cat.No: T35841

Target: Dopamine Receptor, 5-HT Receptor

Coproporphyrin I dihydrochloride

Cat.No: T68846

Target: Others

5-HT7 receptor ligand 1

Cat.No: T61515

Target: Others

Nordoxepin hydrochloride

Cat.No: T37307

Target: Others

Cat.No: T70391

Target: Others

Cat.No: T62610

Target: Others

Resorufin benzyl ether

Cat.No: T37788

Ga(III) protoporphyrin IX

Cat.No: T39700

Target: Others

Imidafenacin Metabolite M4

Cat.No: T36662

Synonym: Imidafenacin Metabolite M4

Target: Others

N-hydroxy Riluzole

Cat.No: T35919

Target: Others

Dolutegravir O-β-D-Glucuronide

Cat.No: T36794

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3797	Isosilybin Isosilybinin,Isosilibinin,异水飞蓟宾,Silymarin,Silybin B,Q-100795	P450	Metabolism
	Isosilybin (Isosilibinin) 是一种类黄酮，来源于乳蓟；能够抑制CYP3A4诱导(IC50:74 μM)。
T5567	Tetradecanedioic acid 十四烷二酸,Tetradecanedicarboxylate	Others; Endogenous Metabolite	Metabolism; Others
	Tetradecanedioic acid (Tetradecanedicarboxylate) 是一种长链脂肪酸，属于内源性代谢物的一种。它能够作为有机阴离子转运多肽介导的药物-药物相互作用的候选生物标志物。
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
T37810	6',7'-Epoxybergamottin	Others	Others
	6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo...

天然产物

Cat.No: T3797

Synonym: Isosilybinin,Isosilibinin,异水飞蓟宾,Silymarin,Silybin B,Q-100795

Target: P450

Tetradecanedioic acid

Cat.No: T5567

Synonym: 十四烷二酸,Tetradecanedicarboxylate

Target: Others, Endogenous Metabolite

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

6',7'-Epoxybergamottin

Cat.No: T37810

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05321	CYP3A4 Protein, Human, Recombinant (His) P450C3,P450PCN1,CYPIIIA4,CP34,cytochrome P450 family 3 subfa...	Human	E. coli
	CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-drug interactions. Systemic inflammation has been linked to suppressed CYP3A4 activity.

重组蛋白

CYP3A4 Protein, Human, Recombinant (His)

Cat.No: TMPY-05321

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼