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Search Results for " degradation product "

Targets Recommended: Others

58

抑制剂 & 化合物

23

天然产物

3

TargetMol 试剂盒

6

重组蛋白

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Cat. No.	Product Name	Form	Specificity Of Inhibition
C0045	RIPA Lysis Buffer (Strong) RIPA裂解液(强)	Solution in bottle
C0046	RIPA Lysis Buffer (Medium) RIPA裂解液(中)	Solution in bottle
C0047	RIPA Lysis Buffer (Weak) RIPA裂解液(弱)	Solution in bottle

TargetMol 试剂盒

RIPA裂解液(强)

Cat.No: C0045

RIPA裂解液(中)

Cat.No: C0046

RIPA裂解液(弱)

Cat.No: C0047

Cat. No.	Product Name	Target	Signaling Pathways
T35788	Orlistat Degradation Product (sodium salt)	Others	Others
	Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase.
T20933	Bis(p-chlorophenyl)acetic acid Bis(p-chlorphenyl)essigsaeure,Bis(4-chlorophenyl)acetic acid,DDA (degradation product),DDA	Others	Others
	Bis(p-chlorophenyl)acetic acid is a standard for pesticide residue analysis.
T39598	4-Chlorocatechol	Others	Others
	4-Chlorocatechol, a significant degradation product of 4-chloro-2-aminophenol (4C2AP), serves as a substrate for both catechol 1,2-dioxygenases and chlorocatechol dioxygenase [1] [2].
T21572	Erythromycin A enol ether	Others	Others
	Erythromycin A enol ether 是大环内酯类抗生素红霉素A 的降解产物。
T7440	p,p'-DDE p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene,2，2-双（4-氯苯基）-1，1-二氯乙烯	Androgen Receptor; Drug Metabolite	Endocrinology/Hormones; Metabolism
	p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) 是持久性 DDT 的主要代谢物。4,4'-DDE 是一种有效的雄激素受体拮抗剂，IC50=5 μM，Ki=3.5 μM。
T38961L	DP-1 hydrochloride DP-1 hydrochloride(1472616-61-7 Free base)	Drug Metabolite	Metabolism
	DP-1 hydrochloride是 SDC-TRAP-0063 的降解产物，是 Ganetespib 的一个片段。Ganetespib 是一种具有抗肿瘤活性的热休克蛋白 90 (HSP90) 抑制剂。
T38003	Levofloxacin N-oxide	Others	Others
	Levofloxacin N-oxide 是从左氧氟沙星中分离出来的杂质。
T0983L	DL-Penicillamine 3-Sulfanylvaline,DL-青霉胺	Antibiotic	Microbiology/Virology
	DL-Penicillamine (3-Sulfanylvaline) 是一种螯合剂，推荐用于去除威尔逊病患者体内多余的铜。它仅存在于使用或服用该药物的个体中。它是青霉素类抗生素最具特征的降解产物。它被用作抗风湿药和威尔逊病的螯合剂。
T34439	Rubreserine	Others	Others
	degradation product
T32527	Lactenocin Demycarosylmacrocin	Others	Others
	Lactenocin is a active degradation product.
T19545	Raloxifene N-Oxide	Others	Others
	Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
T33879	Papaveraldine Xanthaline	Others	Others
	Papaveraldine is a benzylisoquinoline alkaloid that papaverine degradation product.
T71226	Opc 15161	Others	Others
	Opc 15161 is a degradation product of OPC-15160 and superoxide inhibitor.
T39339	Ochratoxin α	Others	Others
	Ochratoxin α is a less toxic photolytic and thermal degradation product of Ochratoxin A.
T19785	Isocyclosporin A IsocyclosporinA,Isocyclosporin-A	Others	Others
	Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.
T84986	Descarbonyl Lacosamide DP-I	Others	Others
	Descarbonyl-lacosamide is a potential impurity in commercial lacosamide preparations. It is a degradation product that forms under acidic conditions.
T38177	Flambalactone	Others	Others
	Flambalactone is a degradation product formed by methanolysis of the antibiotic flambamycin.
T35882	Rizatriptan N-oxide	Others	Others
	Rizatriptan N-oxide is a potential impurity found in commercial preparations of rizatriptan.1It is a degradation product formed under oxidative conditions.
T11000	Descarbamoyl cefuroxime	Others	Others
	Descarbamoyl cefuroxime is also an intermediate in the synthesis of cephalosporin antibiotics. Decarbamyl cefuroxime is a degradation product of cefuroxime.
T36721	Dehydro Amlodipine (fumarate)	Others	Others
	Dehydro amlodipine is a potential impurity found in commercial preparations of amlodipine. It is a degradation product formed during storage or when amlodipine is subjected to oxidative or acidic conditions or undergoes photo or electrochemical degradation.
T19380	Iretol	Others	Others
	Iretol (2,4,6-trihydroxyanisole), serving as an intermediate in the synthesis of natural isoflavones including Tectorigenin, Irigenin, and Caviunin, is identified as a degradation product of a glucoside derived from Iris Jorentina.
T37915	Monodes(N-carboxymethyl)valine Daclatasvir	Others	Others
	Monodes(N-carboxymethyl)valine Daclatasvir, also known as Daclatasvir Impurity A, is the principal degradation product of Daclatasvir.Daclatasvir is a potent inhibitor of the HCV NS5A protein[1].
T37704	Olanzapine Lactam Impurity	Others	Others
	Olanzapine lactam impurity is a potential impurity found in commercial preparations of olanzapine.1It is a degradation product formed by exposure to thermal or oxidative stress. 1.Baertschi, S.W., Brunner, H., Bunnell, C.A., et al.Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulationsJ. Pharm. Sci.97(2)883-892(2008)
T68890	Desvaleryl Valsartan	Others	Others
	Desvaleryl valsartan is a potential impurity found in commercial preparations of the angiotensin II type 1 (AT1) receptor antagonist valsartan. It is a degradation product formed under acidic conditions.
T35734	Doramectin monosaccharide	Others	Others
	Doramectin monosaccharide is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. Doramectin undergoes acid-catalyzed hydrolysis to form doramectin monosaccharide.
T36751	Dihydroxy Melphalan	Others	Others
	Dihydroxy melphalan is an inactive degradation product of melphalan . It is formed by the hydrolysis of melphalan via the intermediate monohydroxy melphalan in aqueous solutions, including cell culture medium and human plasma.
T36599	4-Epianhydrotetracycline hydrochloride	Others	Others
	Epianhydrotetracycline (EATC) is a degradation product of the antibiotic tetracycline .1 EATC is active against Pseudomonas, Agrobacterium, Moraxella, Bacillus, and E. coli (MIC50s = 0.75-16 mg/L).
T84933	Meclizine N-oxide Meclozine N-oxide	Others	Others
	Meclizine N-oxide, a metabolite of the histamine H1 receptor antagonist meclizine (1), also acts as a degradation product and potential impurity in commercial meclizine preparations (2).
T84628	Safinamide Acid	Others	Others
	Safinamide acid, a potential impurity in commercial safinamide preparations and a degradation product of safinamide under thermal and oxidative stress, is encountered in the pharmaceutical formulation process.
T36030	Desethylene Ciprofloxacin (hydrochloride)	Others	Others
	Desethylene ciprofloxacin is a major metabolite of ciprofloxacin . It is also a degradation product of ciprofloxacin that can be created through advanced oxygenation processes as a potential way to remove ciprofloxacin from wastewater. It is also created during degradation of ciprofloxacin by chlorination.
T37380	Pseudoerythromycin A enol ether	Others	Others
	Pseudoerythromycin A enol ether is a degradation product of erythromycin. It does not possess antibiotic activity and can be used as an analytical standard for erythromycin A stability studies.
TP1598	Tyroserleutide hydrochloride
	Tyroserleutide hydrochloride is a small molecule tripeptide isolated from the degradation product of pig spleen, which can inhibit tumor growth in vivo and in vitro.
T38337	Isochlortetracycline	Others	Others
	Isochlortetracycline 是广谱抗生素金霉素降解的无活性碱性产物。
T84927	Lansoprazole N-oxide	Others	Others
	Lansoprazole N-oxide is a potential impurity in lansoprazole bulk preparations, identified as a degradation product under acidic or basic conditions. This compound is related to lansoprazole, a proton pump inhibitor.
T38961	DP-1	Others	Others
	DP-1, a Ganetespib degradation product, represents a fragment derived from SDC-TRAP-0063. Ganetespib itself functions as an inhibitor of heat shock protein 90 (HSP90), exhibiting notable anti-tumor properties.
T35733	Doramectin aglycone	Others	Others
	Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide . Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.
T76587	(Asp28)-Exenatide
	(Asp28)-Exenatide 是艾塞那肽的降解产物。(Asp28)-Exenatide 可用作GLP-1R 激动剂。
T73723	Bifenazate-diazene	Others	Others
	Bifenazate-diazene 是 Bifenazate 的主要降解产物。Bifenazate 是一种选择性杀螨剂和杀虫剂。
T38379	4-tert-Octylphenol diethoxylate	Others	Others
	4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal and human research studies, producing weak estrogenic effects.
T84962	(3R,5R)-Rosuvastatin calcium	Others	Others
	(3R,5R)-Rosuvastatin, a potential impurity detected in bulk rosuvastatin formulations, arises as a degradation product through various stresses including acid or base hydrolysis, thermal, photolytic, hydrolytic, oxidative stress, or during storage. This compound is associated with the HMG-CoA reductase inhibitor class to which rosuvastatin belongs.
T74078	N-Nitrosoglyphosate sodium	Others	Others
	N-Nitrosoglyphosate sodium 是亚硝胺的降解产物，是草甘膦除草剂的合成杂质。
T37246	Palonosetron N-oxide	Others	Others
	Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. 1.Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004) 2.Vishnu Murthy, M., S...
T85127	Monohydroxy Melphalan hydrochloride Hydroxymelphalan	Others	Others
	Monohydroxy melphalan, a degradation product and DNA alkylating agent derived from melphalan, results from melphalan hydrolysis in aqueous solutions such as cell culture medium and human plasma. It enhances DNA adducts in ML-1 myeloblastic leukemia cells based on concentration and induces cytotoxicity with an IC50 value of 28.1 μg/ml.
T85208	4-epi Minocycline 4-EMC,Minocycline Impurity A	Others	Others
	4-epiMinocycline, recognized as a primary degradation product and a probable impurity in minocycline commercial formulations, is derived from minocycline, a broad-spectrum tetracycline antibiotic notable for its extended serum half-life. Besides treating acne, especially in older patients, minocylvania exhibits significant anti-inflammatory and neuroprotective effects.
T36708	Monohydroxy Melphalan (hydrochloride)	Others	Others
	Monohydroxy melphalan is a DNA alkylating agent and a degradation product of melphalan . Monohydroxy melphalan is formed by the hydrolysis of melphalan in aqueous solutions, including cell culture medium and human plasma. It increases the level of DNA adducts in ML-1 myeloblastic leukemia cells in a concentration-dependent manner and induces cytotoxicity with an IC50 value of 28.1 μg/ml.
T85303	(E)-2-Hexadecenal Alkyne Click TagTM (E)-2-Hexadecenal Alkyne	Others	Others
	"(E)-2-Hexadecenal alkyne is a click chemistry probe derivative of the sphingolipid degradation product (E)-2-hexadecenal. This compound has demonstrated the ability to induce cytoskeletal reorganization, leading to cell rounding, detachment, activation of downstream JNK targets, and apoptosis in various cell types. Furthermore, it readily reacts with deoxyguanosine and DNA, forming aldehyde-derived DNA adducts."
T35458	(R)-nitro-Blebbistatin	Others	Others
	(R)-nitro-Blebbistatin is a more stable form of (+)-blebbistatin , which is the inactive form of (-)-blebbistatin . Prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications. The addition of a nitro group stabilizes the molecule to circumvent its degradation by prolonged blue light exposure. (R)-nitro-Blebbistatin has the same stereoche...
T74109	Captopril EP Impurity B	Others	Others
	CaptoprilEPImpurity B 是一种 Captopril 的杂质。Captopril 是一种含巯基的口服活性血管紧张素转换酶(ACE)抑制剂 (IC50=0.025 μM)。
T35929	O-Demethyl Apremilast	Others	Others
	O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral admi...
T36182	Neamine tetrahydrochloride	Others	Others
	Neamine tetrahydrochloride 是一种广谱氨基糖苷类抗生素，一种新霉素的降解产物。Neamine tetrahydrochloride 可通过靶向血管生成素 (angiogenin) 发挥抗血管生成作用。Neamine tetrahydrochloride 具有抗菌，抗肿瘤和神经保护活性。

化合物

Orlistat Degradation Product (sodium salt)

Cat.No: T35788

Target: Others

Bis(p-chlorophenyl)acetic acid

Cat.No: T20933

Synonym: Bis(p-chlorphenyl)essigsaeure,Bis(4-chlorophenyl)acetic acid,DDA (degradation product),DDA

Target: Others

4-Chlorocatechol

Cat.No: T39598

Target: Others

Erythromycin A enol ether

Cat.No: T21572

Target: Others

Cat.No: T7440

Synonym: p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene,2，2-双（4-氯苯基）-1，1-二氯乙烯

Target: Androgen Receptor, Drug Metabolite

DP-1 hydrochloride

Cat.No: T38961L

Synonym: DP-1 hydrochloride(1472616-61-7 Free base)

Target: Drug Metabolite

Levofloxacin N-oxide

Cat.No: T38003

Target: Others

DL-Penicillamine

Cat.No: T0983L

Synonym: 3-Sulfanylvaline,DL-青霉胺

Target: Antibiotic

Cat.No: T34439

Target: Others

Cat.No: T32527

Synonym: Demycarosylmacrocin

Target: Others

Raloxifene N-Oxide

Cat.No: T19545

Target: Others

Cat.No: T33879

Synonym: Xanthaline

Target: Others

Cat.No: T71226

Target: Others

Cat.No: T39339

Target: Others

Isocyclosporin A

Cat.No: T19785

Synonym: IsocyclosporinA,Isocyclosporin-A

Target: Others

Descarbonyl Lacosamide

Cat.No: T84986

Synonym: DP-I

Target: Others

Cat.No: T38177

Target: Others

Rizatriptan N-oxide

Cat.No: T35882

Target: Others

Descarbamoyl cefuroxime

Cat.No: T11000

Target: Others

Dehydro Amlodipine (fumarate)

Cat.No: T36721

Target: Others

Cat.No: T19380

Target: Others

Monodes(N-carboxymethyl)valine Daclatasvir

Cat.No: T37915

Target: Others

Olanzapine Lactam Impurity

Cat.No: T37704

Target: Others

Desvaleryl Valsartan

Cat.No: T68890

Target: Others

Doramectin monosaccharide

Cat.No: T35734

Target: Others

Dihydroxy Melphalan

Cat.No: T36751

Target: Others

4-Epianhydrotetracycline hydrochloride

Cat.No: T36599

Target: Others

Meclizine N-oxide

Cat.No: T84933

Synonym: Meclozine N-oxide

Target: Others

Safinamide Acid

Cat.No: T84628

Target: Others

Desethylene Ciprofloxacin (hydrochloride)

Cat.No: T36030

Target: Others

Pseudoerythromycin A enol ether

Cat.No: T37380

Target: Others

Tyroserleutide hydrochloride

Cat.No: TP1598

Isochlortetracycline

Cat.No: T38337

Target: Others

Lansoprazole N-oxide

Cat.No: T84927

Target: Others

Cat.No: T38961

Target: Others

Doramectin aglycone

Cat.No: T35733

Target: Others

(Asp28)-Exenatide

Cat.No: T76587

Bifenazate-diazene

Cat.No: T73723

Target: Others

4-tert-Octylphenol diethoxylate

Cat.No: T38379

Target: Others

(3R,5R)-Rosuvastatin calcium

Cat.No: T84962

Target: Others

N-Nitrosoglyphosate sodium

Cat.No: T74078

Target: Others

Palonosetron N-oxide

Cat.No: T37246

Target: Others

Monohydroxy Melphalan hydrochloride

Cat.No: T85127

Synonym: Hydroxymelphalan

Target: Others

4-epi Minocycline

Cat.No: T85208

Synonym: 4-EMC,Minocycline Impurity A

Target: Others

Monohydroxy Melphalan (hydrochloride)

Cat.No: T36708

Target: Others

(E)-2-Hexadecenal Alkyne

Cat.No: T85303

Synonym: Click TagTM (E)-2-Hexadecenal Alkyne

Target: Others

(R)-nitro-Blebbistatin

Cat.No: T35458

Target: Others

Captopril EP Impurity B

Cat.No: T74109

Target: Others

O-Demethyl Apremilast

Cat.No: T35929

Target: Others

Neamine tetrahydrochloride

Cat.No: T36182

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T4456	N4-Acetylcytidine N4-乙酰胞苷,N-Acetylcytidine	Others; Endogenous Metabolite	Metabolism; Others
	N4-Acetylcytidine (N-Acetylcytidine) 是内源性代谢产物的一种。
TN1833	Karacoline	NF-κB	NF-κB
	Karacoline 是发现于植物Aconitum kusnezoffii 中的一种二萜生物碱，通过 NF-κB 信号通路，抑制椎间盘退变中细胞外基质的降解。
T8244	Raspberry ketone glucoside 覆盆子酮葡糖苷,树莓苷，覆盆子酮葡萄糖甙	Others	Others
	Raspberry ketone glucoside 是一种山莓果实中的天然产物。它能够抑制黑色素的合成。
TN1892	Lusianthridin	Others; c-Myc	Cell Cycle/Checkpoint; Others
	Lusianthridin 是来自石斛 Dendrobium venustum 的天然产物。 Lusianthridin 在无毒浓度下表现出抗迁移特性。 Lusianthridin 通过抑制 Src-STAT3 信号传导增强 c-Myc 降解。
T2723	Ketoisophorone 茶香酮,4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione	Others	Others
	Ketoisophorone (2,6,6-Trimethyl-2-cyclohexene-1,4-dione) 是工业上重要的环状内酯，是合成类胡萝卜素和调味剂的关键中间体。
T4887	3-Amino-2-methylpropanoic acid DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine	Endogenous Metabolite	Metabolism
	3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物，是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。
T0983	Penicillamine 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine	Antibiotic	Microbiology/Virology
	Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物，是一种螯合剂，可作用于威尔逊氏病。
T19124	3-Oxocholic acid 3-Ketocholic acid	Endogenous Metabolite	Metabolism
	3-Oxocholic acid(3-Ketocholic acid) 是胆汁酸的代谢产物，也是产气荚膜梭菌在肠道中由胆汁降解的主要产物。33-Oxocholic acid 是一种主要存在于哺乳动物的胆汁中类固醇酸。
T5248	(R)-3-Hydroxybutanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	(R)-3-Hydroxybutanoic acid 是一种代谢物，在 3-羟基丁酸脱氢酶催化下由乙酸乙酯转化而成。它可以作为营养来源和抗生素、维生素和信息素的前体。
T5060	2-Oxobutanoic acid 2-酮丁酸,alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid	Others; Endogenous Metabolite	Metabolism; Others
	2-Oxobutanoic acid (alpha-Ketobutyric Acid) 是一种胱硫醚的酶促裂解产物。它也是苏氨酸的降解产物之一。它能够转化为丙酰辅酶A，从而进入柠檬酸循环。
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T6599	N6-methyladenosine N6-甲基腺苷,N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	N6-Methyladenosine 是甲基化的腺嘌呤残基，苷是转移核糖核酸降解的内源性尿核苷产物。它是存在于所有高等真核生物中最普遍的的信使 RNA 内部修饰，可修饰病毒 RNA，有抗病毒活性。
T5236	N-Methylhydantoin 甲酰乙内脲,Dioxy-creatinine,1-Methyl-hydantoin	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylhydantoin (1-Methyl-hydantoin) 是一种小分子量极性物质，是细菌降解肌酐的产物。在哺乳动物中，N-Methylhydantoin 的代谢是通过 5-hydroxy-1-methylhydantoin 进行的。在一个报告的人类病例中，N-Methylhydantoin 被发现是影响智力的物质dupracetam的代谢物。
T0665	Xanthine 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine	Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Xanthine (Isoxanthine) 是一种植物生物碱，存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂，也是嘌呤降解途径的中间产物。
TCS2070	Homogentisic acid 高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物，可用于尿黑酸尿症的诊断。
T10619	Bromelain	Apoptosis; Others	Apoptosis; Others
	Bromelain 是来源于菠萝茎的一种抗炎药，可诱导细胞凋亡，具有纤维蛋白溶解、抗癌、抗水肿和抗血栓形成活性。它通过下调血浆激肽原，抑制前列腺素 E2 表达，降解晚期糖基化终产物受体，在COX 途径上游发生抗氧化作用以及调节血管生成生物标志物而发挥作用。
T4716	Pyrrole-2-carboxylic acid 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline	Endogenous Metabolite	Metabolism
	Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类，从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。
T4799	Indole	Others; Endogenous Metabolite	Metabolism; Others
	Indole 它具有双环结构，由一个六元苯环和一个五元含氮吡咯环融合而成。它可以由细菌作为氨基酸色氨酸的降解产物产生。它自然存在于人类粪便中，有强烈的粪便气味。然而，在非常低的浓度下，它有一种花香，是许多花香(如橙花)和香水的成分。
T5089	5-Aminovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	5-Aminovaleric acid 被认为是 GABA 的亚甲基同系物，是GABA 的弱激动剂。它是赖氨酸降解产物。它既能够内源性产生，也能够通过赖氨酸的细菌分解代谢产生。
T40347	Eicosapentaenoic acid methyl ester	Others	Others
	Eicosapentaenoic acid methyl ester is a degradation product derived from monogalactosyl diacylglycerol, which is an apoptosis-inducing anticancer compound.
T35743	Ivermectin B1a aglycone	Others	Others
	Ivermectin B1a aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.
TN7549	2-epi-Abamectin epi-Avermectin B1a	Others	Others
	2-epi-Abamectin, a degradation product of abamectin, exhibits toxicity towards the two-spotted spider mite in contact assays, possessing an LC50 value of 4 ppm. This indicates it is approximately 100-fold less potent than its precursor, abamectin.

天然产物

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

N4-Acetylcytidine

Cat.No: T4456

Synonym: N4-乙酰胞苷,N-Acetylcytidine

Target: Others, Endogenous Metabolite

Cat.No: TN1833

Target: NF-κB

Raspberry ketone glucoside

Cat.No: T8244

Synonym: 覆盆子酮葡糖苷,树莓苷，覆盆子酮葡萄糖甙

Target: Others

Cat.No: TN1892

Target: Others, c-Myc

Cat.No: T2723

Synonym: 茶香酮,4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione

Target: Others

3-Amino-2-methylpropanoic acid

Cat.No: T4887

Synonym: DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine

Target: Endogenous Metabolite

Cat.No: T0983

Synonym: 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine

Target: Antibiotic

3-Oxocholic acid

Cat.No: T19124

Synonym: 3-Ketocholic acid

Target: Endogenous Metabolite

(R)-3-Hydroxybutanoic acid

Cat.No: T5248

Target: Others, Endogenous Metabolite

2-Oxobutanoic acid

Cat.No: T5060

Synonym: 2-酮丁酸,alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid

Target: Others, Endogenous Metabolite

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

N6-methyladenosine

Cat.No: T6599

Synonym: N6-甲基腺苷,N-Methyladenosine,6-Methyladenosine,NSC-29409,m6A

Target: Others, Influenza Virus, Endogenous Metabolite

N-Methylhydantoin

Cat.No: T5236

Synonym: 甲酰乙内脲,Dioxy-creatinine,1-Methyl-hydantoin

Target: Others, Endogenous Metabolite

Cat.No: T0665

Synonym: 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine

Target: Endogenous Metabolite, Adenosine Receptor

Homogentisic acid

Cat.No: TCS2070

Synonym: 高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid

Target: Antioxidant, Endogenous Metabolite

Cat.No: T10619

Target: Apoptosis, Others

Pyrrole-2-carboxylic acid

Cat.No: T4716

Synonym: 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline

Target: Endogenous Metabolite

Cat.No: T4799

Target: Others, Endogenous Metabolite

5-Aminovaleric acid

Cat.No: T5089

Target: Others, Endogenous Metabolite

Eicosapentaenoic acid methyl ester

Cat.No: T40347

Target: Others

Ivermectin B1a aglycone

Cat.No: T35743

Target: Others

2-epi-Abamectin

Cat.No: TN7549

Synonym: epi-Avermectin B1a

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00507	TREM2 Protein, Cynomolgus, Recombinant (His) TREM2,Trem2a,PLOSL2,TREM-2,Trem2c,Trem2b	Cynomolgus	HEK293 Cells
	TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta prote...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,CVFk,CVF	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...
TMPY-03749	LC3B Protein, Human, Recombinant (His) microtubule-associated protein 1 light chain 3 beta,ATG8F,MA...	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal...
TMPY-01711	Serpin B2 Protein, Human, Recombinant (GST) PAI,serpin peptidase inhibitor, clade B (ovalbumin), member ...	Human	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein that belongs to the serpin fa...
TMPY-02519	BLVRB Protein, Human, Recombinant (His) HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i...
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His) IkB α,IKBA,nuclear factor of kappa light polypeptide gene en...	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NFKBIA inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. Also, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-kB's proper function...

重组蛋白

TREM2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00507

Species: Cynomolgus

Expression System: HEK293 Cells

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

LC3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03749

Species: Human

Expression System: E. coli

Serpin B2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01711

Species: Human

Expression System: Baculovirus Insect Cells

BLVRB Protein, Human, Recombinant (His)

Cat.No: TMPY-02519

Species: Human

Expression System: E. coli

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

Cat.No: TMPY-01710

Species: Human

Expression System: E. coli

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