cereblon ligand-3

Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) 包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate which is designed using Thalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is synthesized specifically for utilization in PROTAC technology.

Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。

Aster-A Ligand-3 是 E3 ligase 的一种配体，可用于合成 PROTACAster-A 降解剂。

cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1].

TSPO ligand-3为AUTAC2的配体，其中AUTAC2包含p-氟苄基鸟嘌呤(FBnG)及FKBP合成配体(SLF)两部分，能在HeLa细胞中显著沉默FKBP12蛋白。

PROTACIRAK4 ligand-3 为 PROTACIRAK4 degrader-7 配体，适用于癌症研究领域。

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

Cereblon Ligand -Linker Conjugates 2 TFA 是一种 E3 连接酶配体- linker 偶联物，包含基于 Thalidomide 的 cereblon 配体和 linker。

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体，可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。

Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) 是一种基于沙利度胺的 Cereblon 配体，通过 linker 与 IRAK4 蛋白配体结合形成 PROTACIRAK4 degrader-1。

Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是 E3 连接酶配体-linker 偶联物，可用于合成 PROTAC BCL-XL 降解剂 XZ739。

Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 的合成。

FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells.

E3 ligase Ligand 23 是一种 cereblon 结合剂，可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。

Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) 是一种由 E3 连接酶配体和连接体组成的偶联物，结合了基于 Thalidomide 的 Cereblon 配体和 3 个单元 PEG Linker。

Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，。

Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。

Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate, which combines the cereblon ligand derived from Thalidomide with a linker utilized in PROTAC technology.

Pomalidomide-PEG3-C2-NH2 hydrochloride, also known as Cereblon Ligand-Linker Conjugate 5, is a chemically synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Pomalidomide and a linker commonly employed in PROTAC technology.

Pomalidomide-PEG3-azide is a chemically synthesized conjugate comprised of a cereblon ligand based on Pomalidomide, an E3 ligase ligand-linker, and a 3-unit PEG linker. This conjugate is specifically designed for use in PROTAC technology.

Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology.

Thalidomide-O-C8-COOH，一种Thalidomide衍生的Cereblon配体，能有效募集CRBN蛋白。通过linker，Thalidomide-O-C8-COOH可与靶蛋白配体结合，构建PROTAC分子。

Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized conjugate compound that serves as an E3 ligase ligand-linker. It features a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology.

Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1].

Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) 是一种合成的 E3 连接酶配体-linker 偶联物，包含基于 Pomalidomide 的 cereblon 配体和 3 单元 PEG 的linker。

ZXH-3-26 是由 Cereblon 配体、E3 泛素连接酶和 BRD4 配体组成的 PROTAC，可用于研究癌症。

SJ10542 是一种有效的选择性 JAK2/3导向苯基戊二酰亚胺 (PG)-PROTAC，对 JAK2、JAK3 和 JAK2-fusion ALL 的 DC50分别为 14、11 和 24 nM。SJ10542 利用 PG 配体作为cereblon(CRBN) 招募剂。

Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1].

Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]

Pomalidomide 4'-PEG3-azide 是一个包含 Pomalidomide 的 cereblon 配体和 1 个 linker 的 E3 连接酶配体-linker 偶联物，可用于 iRucaparib-TP3 的合成。

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications.

Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.