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Search Results for " calpain "

Targets Recommended: Cysteine Protease Proteasome

37

抑制剂 & 化合物

4

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2470	MDL-28170 Calpain Inhibitor III	Cysteine Protease; Proteasome	Proteases/Proteasome; Ubiquitination
	MDL-28170 (Calpain Inhibitor III) 是一种选择性的、有效的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可在全身给药后迅速穿过血脑屏障。它还能阻断γ-secretase。
T6583	MG-101 ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101,钙蛋白酶抑制剂I	Cysteine Protease; Proteasome	Proteases/Proteasome; Ubiquitination
	MG-101 (Calpain inhibitor I) 是一种有效的半胱氨酸蛋白酶抑制剂，能够抑制钙蛋白酶I (Ki:190 pM)，钙蛋白酶II (Ki:220 pM)，组织蛋白酶B (Ki:150 pM)和组织蛋白酶L (Ki:500 pM)。
T38931	Calpain Inhibitor-1	Others	Others
	Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM.
T21949	Calpain Inhibitor XII	Others	Others
	(Rac)-Calpain Inhibitor XII是一种可逆的，选择性抑制钙蛋白酶I（calpain I; μ-calpain）的化合物，具有19 nM的Ki值。其对钙蛋白酶II（calpain II; m-calpain; Ki=120 nM）和组织蛋白酶B（cathepsin B; Ki=750 nM）显示出较低的抑制亲和力。(Rac)-Calpain Inhibitor XII用于研究钙蛋白酶在多种生理过程中的角色，如嗜中性粒细胞趋化性、神经元信号传导和心脏对损伤的响应。
T72439	Calpain Inhibitor XI	Others	Others
	Calpain Inhibitor XI，一种可逆的calpain-1共价抑制剂，适用于神经退行性疾病的研究。
T28786	SJA6017 SJA-6017,Calpain Inhibitor VI,Calpain-In-4,SJA 6017,Calpain Inhibitor 4	Others	Others
	SJA6017 is a inhibitor of calpain-1 (IC50 = 7.5 nM) and calpain-2 ( IC50 = 78 nM). SJA6017 also inhibits cathepsins B (IC50s = 15 nM) and cathepsins L (IC50s = 1.6 nM). SJA6017 reduces apoptotic cell death, preserves spinal cord tissue and improves functi
T78632	Z-LLY-FMK Calpain Inhibitor IV	Proteasome	Proteases/Proteasome; Ubiquitination
	Z-LLY-FMK (Calpain Inhibitor IV) 为一种钙蛋白酶抑制剂，涉及调控多个细胞系统的凋亡过程。该化合物能够抑制胆总管结扎所引起的肠细胞凋亡(apoptosis)。
T14187	ALLM Calpain inhibitor II	Others	Others
	ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
T80551	Calpain inhibitor V Mu-Val-HPh-FMK	Antibiotic	Microbiology/Virology
	Calpain inhibitor V (Mu-Val-HPh-FMK) 为具抗衣原体活性的细胞渗透性不可逆钙蛋白酶抑制剂。
T63391	Calpain Inhibitor-2	Others	Others
	Calpain Inhibitor-2 是具有亲脂性的钙蛋白酶抑制剂，与黑色素瘤细胞系（A-375和B-16F1）和PC-3前列腺癌细胞相比，他们在体外具有中等到良好的抗增殖效果。Calpain Inhibitor-2 中的化合物3，在基质胶细胞侵袭测定中以2μM 浓度能够抑制了80%的DU-145细胞侵袭。
T63708	Calpain-2-IN-1	Others	Others
	Calpain-2-IN-1是选择性的钙蛋白酶-2抑制剂，能够延长 ERK 激活，进而增强学习和记忆。
T2154	MG-132 Z-LLL-al,Z-Leu-Leu-Leu-CHO	Apoptosis; Proteasome; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
	MG-132 (Z-Leu-Leu-Leu-al) 是一种 26S 蛋白酶体抑制剂 (IC50=100 nM)，具有细胞渗透性、可逆性。MG-132 可作为自噬激活剂，可诱导凋亡。
T9710	Dazcapistat	Cysteine Protease	Proteases/Proteasome
	Dazcapistat 是一种有效的 calpain 抑制剂，对 calpain 1、calpain 2 和 calpain 9 的 IC50 值均 <3 μM。
T2493	PD 151746	Cysteine Protease; Proteasome	Proteases/Proteasome; Ubiquitination
	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
T6432	Calpeptin	Apoptosis; Cysteine Protease; Proteasome	Apoptosis; Proteases/Proteasome; Ubiquitination
	Calpeptin 是一种具有细胞穿透性的calpain 抑制剂，也是cathepsin K 抑制剂，其对人血小板 Calpain I 的ID50值为40 nM。
T3525	PD150606	Cysteine Protease	Proteases/Proteasome
	PD150606 是一种具有选择性的非肽 calpain 抑制剂，具有神经保护活性，抑制 μ-calpains 和 m-calpains ，抑制红藻氨酸诱导的 Ca2+ 内流，干扰兴奋性毒性依赖性运动神经元死亡。
TP2056L	Acetyl-Calpastatin (184-210)(human) acetate Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base )	Cysteine Protease	Proteases/Proteasome
	Acetyl-Calpastatin (184-210)(human) acetate 是一种有效，选择性和可逆的钙蛋白酶 (calpain) 抑制剂，对 μ-钙蛋白酶和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。
T60150	(1S,2R)-Alicapistat	Cysteine Protease	Proteases/Proteasome
	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound effectively addresses the metabolic liability associated with carbonyl reduction, while demonstrating potent inhibition of calpain 1 with an IC50 value of 395 nM [2].
T36352	Suc-Leu-Tyr-AMC
	Suc-Leu-Tyr-AMC 是钙蛋白酶 I 和 II 以及木瓜蛋白酶（另一种半胱氨酸蛋白酶）的荧光底物，用于测量 20S 蛋白酶体的糜蛋白酶样肽酶活性（Ex-max：360 nm；Em-max：460 nm）。Suc-Leu-Tyr-AMC 也能被大肠杆菌的 Ti 蛋白酶裂解。
T6040	Aloxistatin E64d,Loxistatin,阿洛司他丁,E64c ethyl ester	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Aloxistatin (E64d) 是一种不可逆的、可透过膜的溶酶体和细胞溶质半胱氨酸蛋白酶抑制剂，能够抑制完整血小板中的钙蛋白酶活性。它是一种半胱氨酸蛋白酶抑制剂，具有血小板聚集抑制活性。
T23598	A-953227 A 953227,A953227	Others	Others
	A-953227 is a highly effective and selective inhibitor of calpain. A-953227 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
T68728	EP 459	Others	Others
	EP 459 is a thiol and calpain protease inhibitor.
T13486	Neurodegenerative Disorder-Targeting Compound 1	Others	Others
	Neurodegenerative Disorder-Targeting Compound 1 是一种靶向 calpain 的抑制剂。
T84437	Ac-Calpastatin (184-210) Calpastatin Peptide B27-WT	Others	Others
	Calpastatin (184-210), an acetylated synthetic peptide derived from human calpastatin, effectively inhibits the calcium-dependent cysteine proteases, calpain I (µ-calpain) and calpain II (m-calpain), which require micromolar and millimolar calcium concentrations, respectively. Unlike its action on calpains, this 27 amino acid peptide does not inhibit papain (a cysteine protease) or trypsin (a serine protease). Encoded by exon 1B of Ac-calpastatin (184-210), it aligns with a section of inhibitory...
T80103	Z-Leu-Tyr-Chloromethylketone
	Z-Leu-Tyr-Chloromethylketone是一种抑制剂，专门针对钙蛋白酶(calpain)活性。
T25011	AK-295 CX295,CX 295,AK295,CX-295	Others	Others
	AK 295, also known as CX 295, is a dipeptide inhibitor of alpha-ketoamide calpain.
T25009	AK 275 AK275,AK-275	Others	Others
	AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro.
T83527	(Rac)-Neurodegenerative Disorder-Targeting Compound 1	Others	Others
	(Rac)-Neurodegenerative Disorder-Targeting Compound 1为一种针对神经退行性疾病的化合物，具有calpain抑制活性。
TP2056	Acetyl-Calpastatin(184-210)(human) Acetyl-Calpastatin (184-210) (human)
	Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.
T23596	A-933548 A933548,A 933548	Others	Others
	A-933548 is a potent Calpain inhibitor. A-933548 features enhanced selectivity versus related cysteine protease cathepsins, favorable microsomal stability, and efficacy in cellular assays.
T75794	Acetyl-Calpastatin(184-210)(human) TFA
	Acetyl-Calpastatin(184-210)(human) TFA 是一种有效，选择性和可逆的钙蛋白酶 (calpain) 抑制剂，对 μ-钙蛋白酶和组织蛋白酶 L 的Ki 值分别为 0.2 nM 和 6 μM。
T76364	Ac-Leu-Leu-Norleucinol
	Ac-Leu-Leu-Norleucinol 是钙蛋白酶抑制剂，可用于研究对 Acetaminophen 引起的急性肝损伤，并能够降低诱导引发的谷草转氨酶 (ALT) 和谷丙转氨酶 (AST) 水平。
T80241	Calpastatin subdomain B	Proteasome	Proteases/Proteasome; Ubiquitination
	Calpastatin subdomain B为具有生物活性的肽，其作用为抑制钙蛋白酶活性。
T36854	Pheleuin	Others	Others
	Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde. Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S. aureus virulence factor expression.
T14187L	ALLM acetate（110115-07-6 Free base)
	ALLM acetate（110115-07-6 Free base) 是一种有效的钙蛋白酶和组织蛋白酶抑制剂，不仅可以防止神经元细胞死亡，还可以增强脊髓损伤（SCI）后的慢性神经功能。
T68547	SNJ-1945	Others	Others
	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a...
T83406	2,3-Diphospho-D-glyceric acid pentasodium salt 2,3-DPG pentasodium salt	Others	Others
	2,3-Diphospho-D-glyceric acid pentasodium salt 是一种聚磷化合物，具有明显的阴离子性质。它在红细胞的凹中心起作用，通过结合血红蛋白降低氧亲和力。作为血管钙化 (VC) 的内源性选择性抑制剂，2,3-Diphospho-D-glyceric acid 能显著推迟结晶钙蛋白颗粒 (CPP) 的生成，并在小鼠血管平滑肌细胞系 (MOVAS) 中抑制钙化作用，同时不引起细胞毒性。

化合物

Cat.No: T2470

Synonym: Calpain Inhibitor III

Target: Cysteine Protease, Proteasome

Cat.No: T6583

Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101,钙蛋白酶抑制剂I

Target: Cysteine Protease, Proteasome

Calpain Inhibitor-1

Cat.No: T38931

Target: Others

Calpain Inhibitor XII

Cat.No: T21949

Target: Others

Calpain Inhibitor XI

Cat.No: T72439

Target: Others

Cat.No: T28786

Synonym: SJA-6017,Calpain Inhibitor VI,Calpain-In-4,SJA 6017,Calpain Inhibitor 4

Target: Others

Cat.No: T78632

Synonym: Calpain Inhibitor IV

Target: Proteasome

Cat.No: T14187

Synonym: Calpain inhibitor II

Target: Others

Calpain inhibitor V

Cat.No: T80551

Synonym: Mu-Val-HPh-FMK

Target: Antibiotic

Calpain Inhibitor-2

Cat.No: T63391

Target: Others

Calpain-2-IN-1

Cat.No: T63708

Target: Others

Cat.No: T2154

Synonym: Z-LLL-al,Z-Leu-Leu-Leu-CHO

Target: Apoptosis, Proteasome, Autophagy

Cat.No: T9710

Target: Cysteine Protease

Cat.No: T2493

Target: Cysteine Protease, Proteasome

Cat.No: T6432

Target: Apoptosis, Cysteine Protease, Proteasome

Cat.No: T3525

Target: Cysteine Protease

Acetyl-Calpastatin (184-210)(human) acetate

Cat.No: TP2056L

Synonym: Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base )

Target: Cysteine Protease

(1S,2R)-Alicapistat

Cat.No: T60150

Target: Cysteine Protease

Suc-Leu-Tyr-AMC

Cat.No: T36352

Cat.No: T6040

Synonym: E64d,Loxistatin,阿洛司他丁,E64c ethyl ester

Target: SARS-CoV, Cysteine Protease

Cat.No: T23598

Synonym: A 953227,A953227

Target: Others

Cat.No: T68728

Target: Others

Neurodegenerative Disorder-Targeting Compound 1

Cat.No: T13486

Target: Others

Ac-Calpastatin (184-210)

Cat.No: T84437

Synonym: Calpastatin Peptide B27-WT

Target: Others

Z-Leu-Tyr-Chloromethylketone

Cat.No: T80103

Cat.No: T25011

Synonym: CX295,CX 295,AK295,CX-295

Target: Others

Cat.No: T25009

Synonym: AK275,AK-275

Target: Others

(Rac)-Neurodegenerative Disorder-Targeting Compound 1

Cat.No: T83527

Target: Others

Acetyl-Calpastatin(184-210)(human)

Cat.No: TP2056

Synonym: Acetyl-Calpastatin (184-210) (human)

Cat.No: T23596

Synonym: A933548,A 933548

Target: Others

Acetyl-Calpastatin(184-210)(human) TFA

Cat.No: T75794

Ac-Leu-Leu-Norleucinol

Cat.No: T76364

Calpastatin subdomain B

Cat.No: T80241

Target: Proteasome

Cat.No: T36854

Target: Others

ALLM acetate（110115-07-6 Free base)

Cat.No: T14187L

Cat.No: T68547

Target: Others

2,3-Diphospho-D-glyceric acid pentasodium salt

Cat.No: T83406

Synonym: 2,3-DPG pentasodium salt

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。
T19384	Isovalerylcarnitine	Apoptosis; Cysteine Protease	Apoptosis; Proteases/Proteasome
	Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物，也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂，可促使细胞凋亡，与异戊酸血症有关，可作为异戊酸血症的标志。
T36931	Penicillide	Others	Others
	Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.
TN1086	Dehydrotrametenolic acid Dehydroeburicoic acid,去氢齿孔酸,松苓新酸	Apoptosis; TNF; NOS; Caspase; NO Synthase	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Dehydrotrametenolic acid (Dehydroeburicoic acid) 是从茯苓的菌核中分离的一种甾醇，具有抗肿瘤活性、抗炎和抗糖尿病作用。它通过 caspase-3途径诱导细胞凋亡。

天然产物

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

Isovalerylcarnitine

Cat.No: T19384

Target: Apoptosis, Cysteine Protease

Cat.No: T36931

Target: Others

Dehydrotrametenolic acid

Cat.No: TN1086

Synonym: Dehydroeburicoic acid,去氢齿孔酸,松苓新酸

Target: Apoptosis, TNF, NOS, Caspase, NO Synthase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01031	CAPN2 Protein, Human, Recombinant (His) Calpain-2 catalytic subunit,Millimolar-calpain<...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82...
TMPH-01029	CAPN1 Protein, Human, Recombinant (His) CANPL1,CAPN1,Calpain-1 catalytic subunit,Micromolar...	Human	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. CAPN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.9 kDa and the accession number is P07384.
TMPH-02557	CAPN1 Protein, Mouse, Recombinant (His) CANP 1,Calpain-1 catalytic subunit,muCANP,CANPL1,Ca...	Mouse	E. coli
	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'.
TMPH-01030	CAPN14 Protein, Human, Recombinant (His & Myc) Calpain-14,Calcium-activated neutral proteinase 14,...	Human	Baculovirus Insect Cells
	Calcium-regulated non-lysosomal thiol-protease. CAPN14 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 78.6 kDa and the accession number is A8MX76.
TMPJ-00926	GCA Protein, Human, Recombinant (GST) GCA,Grancalcin,GCL	Human	E. coli
	Grancalcin (GCA) is a member of the penta EF hand subfamily which includes sorcin, calpain and ALG2. Grancalcin is highly expressed bone marrow and also can detected in neutrophils and macrophages. Grancalcin interacts with L-plastin which known to have actin bundling activity. It indicates that Grancalcin may play an important role in the adhesion of neutrophils to fibronectin. Furthermore, Grancalcin localization is dependent upon calcium and magnesium. It associates with both the granule and ...

重组蛋白

CAPN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01031

Species: Human

Expression System: E. coli

CAPN1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01029

Species: Human

Expression System: E. coli

CAPN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02557

Species: Mouse

Expression System: E. coli

CAPN14 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01030

Species: Human

Expression System: Baculovirus Insect Cells

GCA Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00926

Species: Human

Expression System: E. coli

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