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Search Results for " proline rich "

Targets Recommended: FAK PYK2

8

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2314	PF-431396	FAK; PYK2	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF 431396 是一种具有口服活性的 FAK (IC50:2 nM) 和 Pyk2 (IC50:11 nM)的抑制剂。
T6177	PF-562271 besylate PF-00562271 Besylate	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 besylate (PF-00562271 Besylate) 是一种可逆的，有效的，ATP 竞争性的 FAK(IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T2465	PF-562271 PF562271,PF 562271	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T1918	NVP-TAE 226 TAE226	Apoptosis; FAK; c-Met/HGFR; PYK2; IGF-1R	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	NVP-TAE 226 (TAE226) 是一种具有 ATP 竞争性的双重FAK 和IGF-1R 抑制剂，IC50分别为 5.5 nM、140 nM。它还抑制Pyk2、胰岛素受体，IC50分为 3.5 nM、40 nM。
T21768	PF-562271 hydrochloride PF-562271 HCl	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 hydrochloride (PF-562271 HCl) 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T22397	PF-4618433	Others	Others
	PF-4618433 is a dual inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2).
T80408	Bac7(1-35)
	Bac7(1-35)是一种选择性针对革兰氏阴性菌的脯氨酸富集型抗菌肽，在经过膜易位作用后在细胞内发挥效能。
T75870	PR-39 TFA
	PR-39 TFA 是富含脯氨酸和精氨酸的天然抗菌肽，是一种非竞争性，可逆和变构的蛋白酶体 (proteasome) 抑制剂。PR-39 TFA 可逆地结合到蛋白酶体的 α7 亚基上，并通过泛素-蛋白酶体途径阻断 NF-κB 抑制剂 IκBα 的降解。PR-39 TFA 刺激小鼠的血管生成，抑制炎症反应并显着减小心肌梗死面积。

化合物

Cat.No: T2314

Target: FAK, PYK2

PF-562271 besylate

Cat.No: T6177

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Cat.No: T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

Cat.No: T1918

Synonym: TAE226

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

PF-562271 hydrochloride

Cat.No: T21768

Synonym: PF-562271 HCl

Target: FAK, PYK2, CDK

Cat.No: T22397

Target: Others

Cat.No: T80408

Cat.No: T75870

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02909	Sprr2a1 Protein, Mouse, Recombinant (His) small proline-rich protein 2A,Small pr...	Mouse	E. coli
	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Sprr2a1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 13.4 kDa and the accession number is Q9CQK8.
TMPY-03748	BCL2L12 Protein, Human, Recombinant (GST) BCL2-like 12 (proline rich)	Human	E. coli
	BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog...
TMPY-03048	PRAP1 Protein, Human, Recombinant (mFc) UPA,proline-rich acidic protein 1,PRO1195	Human	HEK293 Cells
	PRAP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41.4 kDa and the accession number is AAL16670.1.
TMPY-03076	PRAP1 Protein, Human, Recombinant (His) UPA,PRO1195,proline-rich acidic protein 1	Human	HEK293 Cells
	PRAP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is AAL16670.1.
TMPY-00571	PRELP Protein, Human, Recombinant (mFc) proline/arginine-rich end leucine-rich...	Human	HEK293 Cells
	PRELP Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 68.3 kDa and the accession number is P51888.
TMPH-02116	SPRR2B Protein, Human, Recombinant (His & Myc) Small proline-rich protein 2B,SPRR2B	Human	P. pastoris (Yeast)
	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. SPRR2B Protein, Human, Recombinant (His & Myc) is expressed in yeast with N-10xHis and C-Myc tag. The predicted molecular weight is 12.0 kDa and the accession number is P35325.
TMPH-00997	PRB1 Protein, Human, Recombinant (GST & His) PRB1,Basic salivary proline-rich protein 1	Human	E. coli
	PRB1 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPY-04623	PRRG2 Protein, Human, Recombinant (mFc) PRGP2,proline rich Gla (G-carboxyglutamic ...	Human	HEK293 Cells
	The genes encoding a family of proteins termed proline-rich gamma-carboxyglutamic acid (PRRG) proteins were identified and characterized more than a decade ago. These novel membrane proteins have an extracellular gamma-carboxyglutamic acid (Gla) protein domain and cytosolic WW binding motifs. Several of the PRRG-interacting proteins are essential for a variety of physiologic processes.
TMPY-00572	PRELP Protein, Human, Recombinant proline/arginine-rich end leucine-rich...	Human	HEK293 Cells
	PRELP Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 41.8 kDa and the accession number is P51888.
TMPH-02117	SPRR3 Protein, Human, Recombinant (His & SUMO) Cornifin beta,Esophagin,SPRR3,Small proline-ric...	Human	E. coli
	Cross-linked envelope protein of keratinocytes. SPRR3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.0 kDa and the accession number is Q9UBC9.
TMPH-01605	BAG6 Protein, Human, Recombinant (E. coli, His & Myc) BAT3,BAG6,HLA-B-associated transcript 3,BCL2-associated atha...	Human	E. coli
	BAG6 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.7 kDa and the accession number is P46379.
TMPH-01606	BAG6 Protein, Human, Recombinant (His & Myc) BAG-6,Protein G3,BAG family molecular chaperone regulator 6,...	Human	Baculovirus Insect Cells
	BAG6 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 38.7 kDa and the accession number is P46379.
TMPH-01943	PARP4 Protein, Human, Recombinant (His) Poly [ADP-ribose] polymerase 4,ADP-ribosyltransferase diphth...	Human	E. coli
	PARP4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01255	DNM1L Protein, Human, Recombinant (His & Myc) Dynamin-like protein IV,Dynamin-related protein 1,DLP1,Dympl...	Human	E. coli
	DNM1L Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 84.4 kDa and the accession number is O00429.
TMPJ-01277	CRT2 Protein, Human, Recombinant CALR3,Calreticulin-3,calreticulin-2,calsperin,CRT2	Human	E. coli
	Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy t...
TMPY-02319	Galectin-3 Protein, Human, Recombinant GALBP,CBP35,GAL3,GALIG,MAC2,LGALS2,lectin, galactoside-bindi...	Human	E. coli
	LGALS3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. LGALS3 is a beta-galactoside-binding lectin and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion, and T-cell regulation. LGALS3 has an important role in tumor progression through...
TMPJ-01259	CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc) CD3 epsilon,T-cell antigen receptor complex, epsilon subunit...	Cynomolgus	HEK293 Cells
	T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. The CD3 epsilon subunit of the T cell receptor (TCR) complex contains two defined signaling domains, a proline-rich sequence and an immune tyrosine activation m...
TMPY-01840	TLT-1/TREML1 Protein, Human, Recombinant (His) PRO3438,TLT-1,triggering receptor expressed on myeloid cells...	Human	HEK293 Cells
	Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) do...

重组蛋白

Sprr2a1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02909

Species: Mouse

Expression System: E. coli

BCL2L12 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03748

Species: Human

Expression System: E. coli

PRAP1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03048

Species: Human

Expression System: HEK293 Cells

PRAP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03076

Species: Human

Expression System: HEK293 Cells

PRELP Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00571

Species: Human

Expression System: HEK293 Cells

SPRR2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02116

Species: Human

Expression System: P. pastoris (Yeast)

PRB1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-00997

Species: Human

Expression System: E. coli

PRRG2 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04623

Species: Human

Expression System: HEK293 Cells

PRELP Protein, Human, Recombinant

Cat.No: TMPY-00572

Species: Human

Expression System: HEK293 Cells

SPRR3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02117

Species: Human

Expression System: E. coli

BAG6 Protein, Human, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-01605

Species: Human

Expression System: E. coli

BAG6 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01606

Species: Human

Expression System: Baculovirus Insect Cells

PARP4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01943

Species: Human

Expression System: E. coli

DNM1L Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01255

Species: Human

Expression System: E. coli

CRT2 Protein, Human, Recombinant

Cat.No: TMPJ-01277

Species: Human

Expression System: E. coli

Galectin-3 Protein, Human, Recombinant

Cat.No: TMPY-02319

Species: Human

Expression System: E. coli

CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (aa 22-117, hFc)

Cat.No: TMPJ-01259

Species: Cynomolgus

Expression System: HEK293 Cells

TLT-1/TREML1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01840

Species: Human

Expression System: HEK293 Cells

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