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Search Results for " myofibroblast "

Targets Recommended: Potassium Channel Adrenergic Receptor Autophagy

3

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T3636	(E)-SIS3 SIS3,SIS3 盐酸盐,SIS3 HCl	TGF-beta/Smad	Stem Cells
	(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂，能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。
T12923	(Rac)-SIS3 free base	TGF-beta/Smad	Stem Cells
	SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.

化合物

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

Cat.No: T3636

Synonym: SIS3,SIS3 盐酸盐,SIS3 HCl

Target: TGF-beta/Smad

(Rac)-SIS3 free base

Cat.No: T12923

Target: TGF-beta/Smad

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01269	SMURF2 Protein, Human, Recombinant (His) SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein...	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com...
TMPY-01890	CLIC4 Protein, Human, Recombinant (His) MTCLIC,chloride intracellular channel 4,p64H1,H1,huH1,CLIC4L	Human	E. coli
	Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angio...

重组蛋白

SMURF2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01269

Species: Human

Expression System: E. coli

CLIC4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01890

Species: Human

Expression System: E. coli

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