mi 2

Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用，IC50为 446±28 nM。

MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM)，对动物无毒性。它能够直接与 MALT1 结合，不可逆地抑制蛋白酶功能，并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。

MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂，IC50 为 46 nM。 MI-2-2 与 menin 结合，Kd 为 22 nM。

MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).

Methylisothiazolinone is a powerful synthetic biocide and preservative.

MI-192 是一种选择性 HDAC2和 HDAC3抑制剂，IC50分别为 30 nM 和 16 nM。MI-192 比其他 HDAC 异构体对 HDAC2 3 具有更高选择性。MI-192 诱导髓系白血病细胞凋亡 (apoptosis)。抗癌和神经保护活性。

SAR405838 (MI 773) 是 MI-773 的类似物，具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂，与 MDM2 结合的Ki 值为 0.88 nM。

L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) 是一种表观遗传修饰因子，是肾癌中的表观遗传修饰剂和推定的癌代谢物，可用于肾癌的相关研究。它抑制线粒体肌酸激酶活性，Km 和 Ki 分别为 2.52 mM 和11.13 mM。它可抑制组蛋白去甲基化酶，从而促进组蛋白甲基化。

ROS-IN-2 (compound 85) 为次狼烷三萜衍生物，具有抑制细胞内过量ROS及其他氧化应激源生成的作用，从而保护线粒体避免受损。该化合物在心肌缺血/再灌注（MI/R）损伤研究中具有潜在应用价值。

SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.

MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.

MI-219 is a human double minute 2 (HDM2) inhibitor.

Delcasertib (KAI-9803) hydrochloride 是有效，选择性的 δ 蛋白激酶 C (δPKC) 抑制剂。Delcasertib (KAI-9803) hydrochloride 可改善急性心肌梗死动物模型的缺血再灌注损伤。

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) is a mixture of isothiazolinone-derived biocides.1,2It is effective against Gram-positive and Gram-negative bacteria with MIC values of 0.0002, 0.0002, 0.00005, and 0.00005% (w/w) forS. aureus,P. aeruginosa,A. niger, andC. albicans, respectively.2MCIT/MIT can elicit contact sensitization.3Formulations containing MCIT/MIT have been used for controlling microbial growth in industrial and household products. 1.Frenzel, E., Schmidt, S., Niederweis, M., et al.Importance of porins for biocide efficacy against Mycobacterium smegmatisApplied and Environmental Microbiology77(9)3068-3073(2011) 2.Lundov, M.D., Johansen, J.D., Zachariae, C., et al.Low-level efficacy of cosmetic preservativesInt. J. Cosmet. Sci.33(2)190-196(2011) 3.Scherrer, M.A.R., and Rocha, V.B.Increasing trend of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI)An. Bras. Dermatol.89(3)527-528(2014)

L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.