ethynyl estradiol 3βdglucuronide (hydrate)

Estradiol 3-sulfamate (BLE 00084) 是一种具有口服活性和高效性的甾体雌酮硫酸酯酶（ES）抑制剂。Estradiol 3-sulfamate 对人胎盘微粒体中ES的 K（i）值为73 nM，可用于研究乳腺癌。

D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体，包括糖酵解和糖异生。在糖酵解过程中，它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中，D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源，这一途径已成为癌症化疗的主要靶点。

Ethynyl estradio 是一种高效的生物活性雌激素。

MK2-IN-3 hydrate (MK-2 Inhibitor III) 是一种口服有活性的、ATP 竞争性的MAPKAP-K2 (MK-2)选择性抑制剂(IC50:0.85 nM)。

Ethynyl estradiol 3-β-D-glucuronide is a metabolite of ethynyl estradiol that can be detected in urine.1,2It is used as a marker of estrogen contamination in fresh and saltwater.2 1.Hadd, H.E., Slikker, W., Jr., and Helton, E.D.The synthesis and characterization of the glucopyranosiduronic acids of 17a-ethynylestradiol-17bJ. Steroid Biochem.13(9)1107-1114(1980) 2.Griffith, D.R., Soule, M.C.K., Eglinton, T.I., et al.Steroidal estrogen sources in a sewage-impacted coastal oceanEnviron. Sci.: Processes Impacts18(8)931-1106(2016)

3'-beta-C-Ethynyl-N6-isopentenyl adenosine is a Nucleoside Derivative - 3'-Modified nucleoside, 6-Modified purine nucleoside.

VH 032 linker 3 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 . N/A

(R)-2-Amino-3-cyclohexylpropanoic acid hydrate(1:x) 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66758，CAS号为 213178-94-0。

7-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one hydrate(2:3) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T65146。

3-O-methyl-L-DOPA is a metabolite of L-DOPA , produced by the activity of catechol O-methyltransferase. 3-O-methyl-L-DOPA may have effects of its own or it may compete with the actions of L-DOPA.

Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine .

Intermediates and Building Blocks - Nucleoside base, Electrophile; Heterocyclic Compounds - Pyridine; Scaffolds and Templates

3’-Beta-C-Ethynyl-4-deoxyuridine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。

3'-beta-C-Ethynyl-N6-(m-methoxybenzyl)adenosine is a Nucleoside Derivative - 3'-Modified nucleoside, 6-Modified purine nucleoside.

3'-beta-C-Ethynyl inosine is a Nucleoside Derivative - 3'-Modified nucleoside.

Nucleoside Derivatives –3’-Modified nucleosides；5-Modified pyrimidine nucleosides; Fluoro-modified nucleosides

1',2',3',5'-Tetra-O-benzoyl-2'-beta-C-ethynyl-D- ribofuranose is a carbohydrate derivative.

3'-beta-C-Ethynyl-3-deazauridine is a Nucleoside Derivative - 3'-Modified nucleoside, 3-Deazauridine.

2-Amino-3-mercaptopropanoic acid hydrochloride hydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64500，CAS号为 116797-51-4。

(S)-2-Amino-3-mercaptopropanoic acid hydrochloride hydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66658，CAS号为 207121-46-8。

Estrone-3-Glucuronide is a metabolite of the primary premenopausal estrogen 17β-estradiol .1,2Urinary levels of estrone-3-Glucuronide peak approximately 36 hours prior to ovulation and have been used as a marker of fertility in women. 1.Blackwell, L.F., Brown, J.B., and Cooke, D.Definition of the potentially fertile period from urinary steroid excretion rates. Part II. A threshold value for pregnanediol glucuronide as a marker for the end of the potentially fertile period in the human menstrual cycleSteroids63(1)5-13(1998) 2.Adlercreutz, H., Brown, J., Collins, W., et al.The measurement of urinary steroid glucuronides as indices of the fertile period in womenJ. Steroid Biochem.17(6)695-702(1982)

3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂，也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate，Acadesine ，Clofarabine ，Fludarabine phosphate 和 Vidarabine 。

1-Ethynyl-3-nitrobenzene 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66918，CAS号为 3034-94-4。

Nucleoside Derivatives - 3’-Modified purine nucleosides

6-Amino-3-ethynyl-4-methoxy-1-(b-D-ribofuranosyl)-1H- pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

1',2'-Di-O-acetayl-3',5'-di-O-benzoyl-3'-beta-C-ethynyl-D-ribofuranose is a carbohydrate derivative.

2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole hydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64826。

Nucleoside Derivatives - 3’-Modified nucleosides, Fluoro-modified nucleosides, 5-Modified pyrimidine nucleosides

3-Isomangostin hydrate formate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2955，CAS号为 925705-36-8。

3-Isomangostin hydrate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2954，CAS号为 26063-96-7。

(S)-2-((R)-2-Amino-4-methylpentanamido)-3-(4-hydroxyphenyl)propanoic acid hydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65137，CAS号为 3303-29-5。

Nucleoside Derivatives - 3’-Modified nucleosides, 4-Deoxypyrimidine nucleosides

Nucleoside Derivatives - 3’-Modified nucleosides, Fluoro-modified nucleosides, 6-Modified purine nucleosides

Phenol, m-(1-(p-hydroxyphenethyl)-3-isopropyl-3-pyrrolidinyl)-, hydrochloride, hydrate is a bioactive chemical.

Intermediates and Building Blocks - Nucleoside base, Electrophile, Nucleophile; Heterocyclic Compounds - Pyridine; Scaffolds and Templates

Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) .2,3E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.2 1.Loe, D.W., Almquist, K.C., Cole, S.P., et al.ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroidsThe Journal of Biological Chemisty271(16)9683-9689(1996) 2.Gerk, P.M., Li, W., and Vore, M.Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronideDrug Metabolism and Disposition32(10)1139-1145(2004) 3.Gerk, P.M., Li, W., Megaraj, W., et al.Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholateJournal of Pharmacology and Experimental Therapeutics320(2)893-899(2007)

3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine 是一种腺嘌呤核苷类似物。腺苷类似物大多可作为平滑肌血管扩张剂，也被证明能够抑制癌症进展。它的热门产品有 Adenosine phosphate，Acadesine ，Clofarabine ，Fludarabine phosphate 和 Vidarabine 。

2-Acetamido-3-(1H-imidazol-4-yl)propanoic acid hydrate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64969。

3'-beta-C-Ethynyl-5-methoxyuridine is a Nucleoside Derivative - 3'-Modified nucleoside, 5-Modified pyrimidine nucleoside.

Nucleoside Derivatives - 3’-Modified purine nucleosides; 6-Modified purine nucleosides

Estradiol 3-sulfate 17β-Glucuronide potassium salt (Estradiol 3-sulfate 17-glucuronide potassium) 是一种天然存在的雌激素，竞争性抑制了 MRP 介导的 LTC 转运，可用于研究代谢疾病。