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TMPY-02020
|
ROBO4 Protein, Human, Recombinant (His)
roundabout, axon guidance receptor, homolog 4 (Dros...
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Human
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HEK293 Cells
|
|
ROBO4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49 kDa and the accession number is Q8WZ75-1. |
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TMPY-02631
|
ROBO4 Protein, Mouse, Recombinant (His)
AI593217,roundabout, axon guidance receptor, homolo...
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Mouse
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HEK293 Cells
|
|
ROBO4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.6 kDa and the accession number is A0A0R4J197. |
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TMPY-03045
|
Draxin Protein, Human, Recombinant (His)
C1orf187,AGPA3119,dorsal inhibitory axon guidance p...
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Human
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HEK293 Cells
|
|
Draxin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.5 kDa and the accession number is Q8NBI3. |
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TMPY-02525
|
RGMA Protein, Human, Recombinant (His)
repulsive guidance molecule family member a,RGM
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Human
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HEK293 Cells
|
|
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that form... |
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TMPJ-01148
|
NRN1L Protein, Human, Recombinant (His)
NRN1L,UNQ2446/PRO5725,Neuritin-like protein
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Human
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HEK293 Cells
|
|
Neuritin-like protein belongs to the neuritin family. Neuritin is a GPI-anchored protein that promotes neurite outgrowth and branching of neuritic processes in primary hippocampal and cortical cells. Neuritin expression also enhances the development of motor neuron axon arbors by promoting neuromuscular synaptogenesis and by stimulating the addition of new axon branches. Neuritin is induced by neuronal activity and by the neurotrophins, BDNF and NT3. NRN1L contains a consensus cleavage signal fo... |
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TMPK-01131
|
Neogenin Protein, Human, Recombinant (hFc)
NEO,NGN,IGDCC2,NEO1,neogenin 1
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Human
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HEK293 Cells
|
|
Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axon guidance and cell survival. |
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TMPH-01229
|
DPYSL5 Protein, Human, Recombinant (His & Myc)
ULIP6,CRMP-5,CRMP5,DRP-5,DPYSL5,Dihydropyrimidinase-related ...
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Human
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E. coli
|
|
May have a function in neuronal differentiation and/or axon growth. |
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TMPH-01228
|
DPYSL3 Protein, Human, Recombinant (His)
ULIP-1,DRP-3,Dihydropyrimidinase-related protein 3,DPYSL3,Un...
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Human
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E. coli
|
|
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. |
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TMPH-01226
|
CRMP1 Protein, Human, Recombinant
ULIP3,Collapsin response mediator protein 1,CRMP1,Dihydropyr...
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Human
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E. coli
|
|
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis. CRMP1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted mole... |
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TMPH-01227
|
DPYSL2 Protein, Human, Recombinant (His)
Dihydropyrimidinase-related protein 2,Collapsin response med...
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Human
|
P. pastoris (Yeast)
|
|
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. |
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TMPK-00279
|
RGMA Protein, Human, Recombinant (His & Avi), Biotinylated
RGM,RGMA
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Human
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HEK293 Cells
|
|
Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis (EAE), which is the animal model of multiple sclerosis (MS). |
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TMPK-01200
|
Nogo Receptor/RTN4R Protein, Cynomolgus, Recombinant (His)
NGR,NOGOR,RTN4R,NgR1,Nogo receptor,Nogo-66 receptor
|
Cynomolgus
|
HEK293 Cells
|
|
NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene.RTN4R may modulate the genetic risk or clinical expression of schizophrenia in a subset of patients and identify additional studies that will be necessary to clarify the role of RTN4R in psychiatric phenotypes. |
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TMPH-01875
|
Plexin-B1 Protein, Human, Recombinant (His)
Semaphorin receptor SEP,PLXNB1,Plexin-B1
|
Human
|
E. coli
|
|
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 56.4 kDa and the accession number is O43157. |
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TMPH-01874
|
Plexin-A4 Protein, Human, Recombinant (His)
Plexin-A4,PLXNA4
|
Human
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E. coli
|
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Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Plexin-A4 Protein, Human, Recombinant (His) is expressed in... |
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TMPH-00423
|
Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His)
Tentoxylysin,Tetanus toxin,tetX
|
Clostridium tetani
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E. coli
|
|
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) is expressed in E. coli expression... |
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TMPH-01876
|
Plexin-B1 Protein, Human, Recombinant (mFc)
Plexin-B1,Semaphorin receptor SEP,PLXNB1
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Human
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HEK293 Cells
|
|
Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Plexin-B1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with N-mFc tag. The predicted molecular weight is 83.2 kDa and the accession number is O43157. |
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TMPY-02001
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RTN4 Protein, Human, Recombinant (GST)
UNG1,NOGO,reticulon 4,RTN4-A,Nbla00271,NOGO-A,RTN-X,NSP,UNG1...
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Human
|
E. coli
|
|
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 ... |
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TMPY-03823
|
H Cadherin Protein, Rat, Recombinant (hFc)
cadherin 13
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Rat
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HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
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TMPJ-01402
|
NTNG1 Protein, Human, Recombinant (His)
KIAA0976,Netrin-G1,Laminet-1,NTNG1,LMNT1
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Human
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HEK293 Cells
|
|
Netrin-G1 (NTNG1) is a member of a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development. Netrin-G1 contains one laminin EGF-like domain and one laminin N-terminal domain, Netrin-G1 is highly expressed in the thalamus, lowly in other tissue. Netrin-G1 localizes to the cell membrane. Netrin-G1 interacts with NGL1 and is glycosylated in the N-terminal. In addition, Netrin-G1 can promotesneurite outgrowth of both axons and dendrites. NTNG1 Protein,... |
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TMPK-00278
|
RGMA Protein, Human, Recombinant (His & Avi)
RGMA,RGM
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Human
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HEK293 Cells
|
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Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis (EAE), which is the animal model of multiple sclerosis (MS). RGM is expressed in pathogenic ... |
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TMPJ-01176
|
SEMA4C Protein, Mouse, Recombinant (hFc)
M-Sema F,Semaphorin-C-like 1,Semai,Semaphorin I,Sema4c,Semac...
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Mouse
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HEK293 Cells
|
|
Semaphorin-4C is a protein which belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. As cell surface receptor for PLXNB2, it plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. It required for normal brain development, axon guidance and cell migration, Probable signaling receptor which may play a role in myogenic differentiation through activation of the str... |
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TMPJ-00587
|
NRCAM Protein, Human, Recombinant (hFc)
gCAM-related cell adhesion molecule,hBravo,Ng-CAM-related,Nr...
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Human
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HEK293 Cells
|
|
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptog... |
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TMPY-00450
|
H Cadherin Protein, Mouse, Recombinant (His)
Cdht,T-cadherin,cadherin 13,4932416G01Rik,Tcad
|
Mouse
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HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
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TMPY-05088
|
CNTN6 Protein, Human, Recombinant (hFc)
NB3,contactin 6
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Human
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HEK293 Cells
|
|
Copy number variations (CNVs) of the human CNTN6 gene caused by megabase-scale microdeletions or microduplications in the 3p26.3 region are often the cause of neurodevelopmental disorders, including intellectual disability and developmental delay. Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. The deletion or duplication of the CNTN6 gene is associated with a wide spectrum of neurodevelopmental behavior... |
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TMPJ-01355
|
SEMA4G Protein, Human, Recombinant (His)
Semaphorin-4G,SEMA4G,KIAA1619
|
Human
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HEK293 Cells
|
|
Semaphorin-4G is belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and ve... |
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TMPH-02304
|
Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)
Vasohibin-2,VASH2,Vasohibin-like protein,Tubulinyl-Tyr carbo...
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Human
|
E. coli
|
|
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,... |
|
TMPJ-01293
|
SEMA3C Protein, Human, Recombinant (His)
Semaphorin-E,SEMA3C,SEMAE,Semaphorin-3C,Sema E
|
Human
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HEK293 Cells
|
|
Semaphorin 3C is one of six Class 3 secreted semaphorins, which are potent chemorepellents, that play a role in axon and/or vascular guidance during development can be up-regulated in the process of tumor progression. Semaphorin 3C consists of a 20 amino acids signal sequence, a N-terminal Sema domain, a cysteine knot, a furine-type cleavage site, an Ig-like domain, and a C-terminal basic domain. Semaphorin 3C expressed highly in the heart, colon, skeletal muscle, small intestine, testis, ovary ... |
|
TMPJ-00396
|
SEMA4D Protein, Human, Recombinant (aa 22-734, His)
A8,BB18,Semaphorin-4D,GR3,CD100
|
Human
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HEK293 Cells
|
|
Semaphorin-4D is also known as A8,BB18, GR3, CD100. Semaphorin-4D belongs to the semaphorin family containing 1 Ig-like C2-type domain, 1 PSI domain and 1 Sema domain. It is the cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. It promotes the migration of cerebellar granule cells and of endothelial cells, regulates dendrite and axon branching and morphogenesis. Semaphorin-4D Plays a role in the immune system; Promotes signaling via SRC and PTK2B/P... |
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TMPJ-01400
|
NTNG1 Protein, Human, Recombinant (Avi & His), Biotinylated
LMNT1,NTNG1,KIAA0976,Netrin-G1,Laminet-1
|
Human
|
HEK293 Cells
|
|
Netrin-G1 (NTNG1) is a member of a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development. Netrin-G1 contains one laminin EGF-like domain and one laminin N-terminal domain, Netrin-G1 is highly expressed in the thalamus, lowly in other tissue. Netrin-G1 localizes to the cell membrane. Netrin-G1 interacts with NGL1 and is glycosylated in the N-terminal. In addition, Netrin-G1 can promotesneurite outgrowth of both axons and dendrites. NTNG1 Protein,... |
|
TMPY-03798
|
H Cadherin Protein, Rat, Recombinant (His)
cadherin 13
|
Rat
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPY-00601
|
H Cadherin Protein, Mouse, Recombinant (hFc)
Tcad,T-cadherin,4932416G01Rik,cadherin 13,Cdht
|
Mouse
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
|
TMPY-03948
|
H Cadherin Protein, Rat, Recombinant
cadherin 13
|
Rat
|
HEK293 Cells
|
|
CDH13, also known as cadherin-13 and H Cadherin, is a member of the cadherin superfamily. CDH13 acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. CDH13 is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. CDH13 gene is hypermethylated in many types of cancer. H Cadheri... |
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TMPJ-00355
|
Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated
CD304,VEGF165R,NRP1,NRPNP1,BDCA4
|
Human
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HEK293 Cells
|
|
Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds ... |
|
TMPY-00134
|
Netrin G1/NTNG1 Protein, Human, Recombinant (His)
Lmnt1,netrin G1
|
Human
|
HEK293 Cells
|
|
NTNG1 (Netrin G1) is a Protein Coding gene. This gene encodes a preproprotein that is processed into a secreted protein containing eukaryotic growth factor (EGF)-like domains. NTNG1 is broadly expressed in the brain, kidney, and other tissues. Netrins including NTNG1 are known to be axon guidance factors in the developing brain. It is involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular, and synaptic levels. The NTNG1 protein has an important ro... |
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TMPY-03255
|
ROBO2 Protein, Human, Recombinant (His)
SAX3,roundabout homolog 2 (Drosophila),ROBO2,KIAA1568
|
Human
|
HEK293 Cells
|
|
ROBO2 belongs to the ROBO family. Members of the ROBO family are a group of highly conserved transmembrane glycoproteins that make up a small subgroup of the immunoglobulin (Ig) superfamily. They are best known for their roles as receptors for the Slit family of repellent axon guidance cues. In structure, ROBOs are characterized by five C2-type Ig-like repeats, three fibronectin type III domains, a transmembrane region, and an intracellular domain with three (ROBO3) or four (ROBO1, 2) CC (conser... |
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TMPJ-00821
|
OM Protein, Human, Recombinant (His)
Oncomodulin-1,OCM,OM,OCMN,Parvalbumin Beta,Parvalbumin β,OCM...
|
Human
|
E. coli
|
|
Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to... |
|
TMPJ-01169
|
SEMA4A Protein, Mouse, Recombinant (His)
Semaphorin-4A,Semaphorin-B,Semab,Sema B,Sema4a,SemB
|
Mouse
|
HEK293 Cells
|
|
Semaphorin-4A (SEMA4A) belongs to the semaphorin family which contains a Ig-like C2-type domain, a PSI domain and a Sema domain. SEMA4A is expressed from day 10 in the embryo, and low levels are found between days 10-12. SEMA4A is a cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. It plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A ... |
|
TMPJ-01112
|
PRKG1 Protein, Human, Recombinant (His)
PRKGR1B,PRKG1B,cGKI,cGMP-Dependent Protein Kinase 1,cGK1,cGK...
|
Human
|
HEK293 Cells
|
|
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function,... |
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TMPY-04070
|
Citrate Synthase Protein, Human, Recombinant (His)
citrate synthase
|
Human
|
Baculovirus Insect Cells
|
|
Chondroitin sulphate (CS) glycosaminoglycan chains on cell and extracellular matrix proteoglycans (PGs) can no longer be regarded as merely hydrodynamic space fillers. Overwhelming evidence over recent years indicates that sulphation motif sequences within the CS chain structure are a source of significant biological information to cells and their surrounding environment. CS sulphation motifs have been shown to interact with a wide variety of bioactive molecules, e.g. cytokines, growth factors, ... |
|
TMPY-02300
|
BIN1 Protein, Human, Recombinant (His)
AMPHL,bridging integrator 1,AMPH2,SH3P9
|
Human
|
E. coli
|
|
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased... |
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TMPY-02759
|
Kallikrein 6/KLK6 Protein, Human, Recombinant (His)
kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bssp,SP59,h...
|
Human
|
HEK293 Cells
|
|
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh... |
|
TMPY-01620
|
MDGA2 Protein, Mouse, Recombinant (His)
6720489L24Rik,Adp,MAM domain containing glycosylphosphatidyl...
|
Mouse
|
HEK293 Cells
|
|
MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single... |
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TMPJ-00406
|
EphA8 Protein, Human, Recombinant (His)
EPH- and ELK-related tyrosine kinase,EPH receptor A8,HEK3,Ep...
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Human
|
HEK293 Cells
|
|
EphA8, also known as Hek3 and Eek, is a 120 kDa glycosylated member of the Eph family of transmembrane receptor tyrosine kinases. The A and B classes of Eph proteins are distinguished by Ephrin ligand binding preference but have a common structural organization. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent c... |
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TMPJ-00395
|
SEMA4D Protein, Mouse, Recombinant (hFc)
Semacl2,Sema J,Semaphorin-C-like 2,Semaj,CD100,Semaphorin-4D...
|
Mouse
|
HEK293 Cells
|
|
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. S... |
|
TMPJ-00281
|
CADM1 Protein, Mouse, Recombinant (hFc)
IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...
|
Mouse
|
HEK293 Cells
|
|
Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in... |
|
TMPH-02317
|
YTHDF1 Protein, Human, Recombinant (His)
YTHDF1,Dermatomyositis associated with cancer putative autoa...
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Human
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P. pastoris (Yeast)
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Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradatio... |
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