15
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7943 |
Fluphenazine decanoate
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。 | |||
T24415 |
Lotrifen
Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta |
Others | Others |
Lotrifen (Privaprol) 是一种非激素抗生育药物,Lotrifen 引起妊娠停止和复旧。在胚泡着床后,它直接作用于受精卵,受精卵经历一个缓慢而逐渐的退化过程,并以受精卵的再吸收或排出而结束。 | |||
T24275 |
L 10503
L10503,NSC-298267,NSC298267,L-10503,NSC 298267 |
Others | Others |
L 10503 is an antifertility agent. | |||
T20272 |
Diethyl adipate
AI300342,AI3-00342 AI3 00342,NSC19160,NSC 19160,NSC-19160 |
Others | Others |
Diethyl adipate has an effect of antifertility. | |||
T24187 |
J 628
J-628,J628 |
Others | Others |
J 628 is a synthetic "impeded" estrogen derivative. It also has some postcoital antifertility activity. | |||
T24276 |
L 11204
DL 204IT,L-11204,DL 204 IT,DL 204,L11204 |
Others | Others |
L 11204 is an antifertility in vivo. It is an inhibitor of prostaglandin synthesis. | |||
T9586 |
Broparestrol (E)-
|
Others | Others |
Broparestrol (E)- 具有抗生育活性,是啮齿动物乳腺肿瘤发生的有效抑制剂。 | |||
T28609 |
Rohitukine
NSC623611,NSC-623611,NSC 623611 |
Others | Others |
Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and antileishmanial compound. | |||
T36621 |
Prostaglandin F2β
|
Others | Others |
Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α. | |||
T84574 |
Prostaglandin F2α 1,9-lactone
PGF2α 1,9-lactone |
Others | Others |
Prostaglandin F2α (PGF2α) 1,9-lactone, a lipid-soluble internal ester of PGF2α, demonstrates resistance to hydrolysis by human plasma esterases, maintaining its structure even after 20 hours of incubation under physiological conditions. Unlike PGF2α, this compound exhibits minimal antifertility and vasoactivity. | |||
T36153 |
15(S)-15-methyl Prostaglandin D2
15(S)-15-methyl Prostaglandin D2 |
Others | Others |
15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 . In contrast to PGD2, 15(S)-15-methyl PGD2 induces vasoconstriction and increases systemic blood pressure with much reduced inhibitory activity on ADP-induced platelet aggregation. It also exhibits strong antifertility activity in hamsters (200-fold more potent than PGD2). | |||
T37326 |
Prostaglandin F2α 1,11-lactone
Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) 是前列腺素 F2α 的脂溶性前药,可用于治疗青光眼的研究。 Prostaglandin F2α 1,11-lactone 作为抗生育剂具有活性,可大大降低血管活性。 | |||
T84590 |
17-phenyl trinor Prostaglandin E2
17-phenyl trinor PGE2 |
Others | Others |
17-Phenyl trinor Prostaglandin E2 (17-phenyl trinor PGE2) is a synthetic analog of PGE2, functioning as an agonist at the EP1 and EP3 receptors. It induces contraction of the guinea pig ileum at a 11 µM concentration and displays slightly less potency than PGE2 in stimulating the gerbil colon and rat uterus. Notably, with an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 exhibits 4.4 times greater antifertility efficacy in hamsters compared to PGE2. | |||
T71133 |
Azacosterol hydrochloride
|
Others | Others |
Azacosterol is a diaza derivative of cholesterol which acts as a hypocholesteremic agent by blocking delta-24-reductase causing accumulation of desmosterol. Azacosterol acts as an inhibitor of 24-dehydrocholesterol reductase (24-DHCR), preventing the formation of cholesterol from desmosterol. Although it primarily acts to inhibit 24-DHCR, the drug also inhibits other steps in cholesterol biosynthesis. The antifertility effects of the drug in birds are mediated by inhibition of steroid hormone pr... | |||
T37996 |
17-phenyl trinor Prostaglandin E2 ethyl amide
17-phenyl trinor Prostaglandin E2 ethyl amide |
Others | Others |
17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20217 |
Grandiflorenic acid
|
Others | Others |
Grandiflorenic acid can reproduce the uterine responses induced by aqueous extract of zoapatle leaves. It is suggested that grandiflorenic acid may have an antifertility effect. | |||
TN1890 |
Lupeol acetate
|
Others; TNF; NOS | Apoptosis; Immunology/Inflammation; Others |
Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone. | |||
TN3426 |
Anwuweizonic acid
|
Others | Others |
Anwuweizonic acid may have inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. Mixture of coccinic acid and anwuweizonic acid has antifertility activity, shows significant inhibitory activity against human decidu | |||
TN3686 |
Coccinic acid
|
Others | Others |
Coccinic acid shows inhibitory effects against colorectal carcinoma HCT-15 and oral epithelial cell line KB-3-1.Mixture of coccinic acid and anwuweizonic acid shows significant inhibitory activity against human decidual cells and rat luteal cells in vitro |