uzansertib

Uzansertib (INCB053914) is a potent ATP-competitive pan-PIM kinase inhibitor. It exhibits exceptional inhibitory activity against PIM1, PIM2, and PIM3 with IC50 values of 0.24 nM, 30 nM, and 0.12 nM, respectively. Furthermore, Uzansertib demonstrates significant anti-proliferative effects against an assorted range of hematologic tumor cell lines.

Uzansertib phosphate (INCB053914 phosphate) 是一种可口服的 ATP 竞争性泛-PIM 激酶抑制剂，对多种血液肿瘤细胞系具有广泛的抗增殖活性，对 PIM1、PIM2 和 PIM3 的 IC50分别为 0.24 、30 和 0.12 nM。