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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7769 |
Nonapeptide-1
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5 |
Others | Others |
Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成,这使得它对治疗某些皮肤病很感兴趣。 | |||
T32401 |
KL044
KL 044,KL-044 |
Others | Others |
KL044 是一种隐花色素 1(CRY1) 激活剂,可延长昼夜节律并抑制 PER2 的活性。 KL044 通过抑制cAMP/PKA/CREB 通路来抑制黑色素生成。 | |||
T32907 |
L-Topaquinone
L-Topaquinone residue,2',4',5'-Topaquinone |
Others | Others |
L-Topaquinone is a metabolite of dopaquione, an important intermediate in melanogenesis. | |||
T24607 |
p-Decylaminophenol
p DAP,pDAP,p-DAP |
Others | Others |
p-Decylaminophenol is a melanogenesis inhibitor. | |||
T28035 |
MHY908
|
Others | Others |
MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner. | |||
T19923 |
(+)-Pinanediol
2,3-cs/ex-PinD,2,3-cis/exo-pinanediol |
Others | Others |
(+)-Pinanediol is an effective inducer of melanogenesis. In S91 cells, it acts by inducing higher levels of pigmentation and synthesis of nitric oxide (NO). | |||
T61425 |
Tyrosinase-IN-5
|
Others | Others |
Tyrosinase-IN-5 (compound 16c) is a highly effective inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound efficiently suppresses melanogenesis while posing minimal toxicity to cells [1]. | |||
T79378 |
IIIM-8
|
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
IIIM-8作为一种黑色素生成抑制剂,在体外和体内均表现出显著地抑制色素生成的功效,同时对成人表皮黑色素细胞(HAEM)不表现出细胞毒性。IIIM-8适用于色素沉着症研究。 | |||
T76597 |
Prolylserine
|
||
Prolylserine 是一种二肽,是 Mel-Ab 细胞中黑色素生成的抑制剂。Prolylserine 降低小眼相关转录因子 (MITF) 和酪氨酸酶的表达,诱导ERK 的磷酸化,但不诱导 cAMP 反应元件结合蛋白 (CREB)。 | |||
T72009 |
N-Phenylthiourea
|
Others | Others |
N-Phenylthiourea is a tyrosinase inhibitor and building block. It increases the susceptibility of SK-MEL-188 melanoma cells in melanogenesis-inducing conditions to γ-radiation-induced cytotoxicity when used at a concentration of 0.01 μM. N-Phenylthiourea has been used as a precursor in the synthesis of compounds with antibacterial and antifungal activities. It has also been used as a genetic marker for taste because only some people detect it as a bitter taste. | |||
T75714 |
Decapeptide-12
|
||
Decapeptide-12,一个小型寡肽,作为tyrosinase的抑制剂,通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM),Decapeptide-12有效上调SIRT的转录水平,并能减少黑色素细胞中的黑色素含量,适用于黑色素生成、衰老和炎症的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S0413 |
Pectolinarigenin
柳穿鱼黄素,Pectolinaringenin |
Others; Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience; Others |
Pectolinarigenin (Pectolinaringenin) 是 COX-2/5-LOX 的双重抑制剂,可抑制炎症病变中类花生酸的形成,具有抗炎活性。 | |||
T8244 |
Raspberry ketone glucoside
覆盆子酮葡糖苷,树莓苷,覆盆子酮葡萄糖甙 |
Others | Others |
Raspberry ketone glucoside 是一种山莓果实中的天然产物。它能够抑制黑色素的合成。 | |||
TN5086 |
Syringetin
|
Others | Others |
Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物,可促进 B16F10 细胞的黑色素生成,抑制人肺腺癌中成骨细胞介导的破骨细胞生成。 | |||
T2819 |
Methyl p-coumarate
对羟基肉桂酸乙酯,4-羟基肉桂酸甲酯,Methyl 4-hydroxycinnamate |
Others; Antifungal | Microbiology/Virology; Others |
Methyl 4-hydroxycinnamate 是一种从 Trixis michuacanavarlongifolia 的花中分离出来的对香豆酸的酯化衍生物,有抗菌和抗黑色素形成的作用。 | |||
TN6339 |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one
(5R)-Dihydroyashabushiketol,(R)-5-羟基-1,7-二苯基-3-庚酮 |
Others | Others |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) 是从中药材高良姜的根茎中提取的。它抑制茶碱刺激的鼠 B16 黑色素瘤 4A5 细胞中的黑色素生成。 | |||
T2759 |
Loganin
Loganoside,马钱子苷 |
Apoptosis; NF-κB; BACE; AChR; AChE | Apoptosis; Neuroscience; NF-κB |
Loganin (Loganoside) 是山茱萸中的主要环烯醚萜苷类天然产物,具有抗炎、抗休克的作用。 | |||
T3676 |
Sesamol
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分,具有抗氧化和抗肿瘤活性。它是一种自由基清除剂,在 DPPH 实验中,IC50为 5.95±0.56 μg/mL。 | |||
T3810 |
Saikosaponin B2
柴胡皂苷 B2,柴胡皂甙 B2 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Saikosaponin B2 是从柴胡根中分离得到的一种活性成分,可抑制 HCV 病毒感染的侵入,有抗癌作用。 | |||
T3S0645 |
N-trans-Feruloyltyramine
Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺 |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱,是COX1和COX2的抑制剂,具有抗氧化和抗炎活性。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
TCS2170 |
2,5-Dihydroxyacetophenone
Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 ',5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP |
ERK; NF-κB; Tyrosinase | MAPK; NF-κB; Proteases/Proteasome |
2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物,通过阻断 ERK1/2和 NF-κB 信号通路,抑制活化巨噬细胞中炎症介质的产生。 | |||
T6S1684 |
8-Gingerol
|
Antioxidant; Antibacterial; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction |
8-Gingerol 分离自姜的根状茎,是口服有效的 TRPV1激活剂,EC50值为5.0 µM。8-Gingerol 抑制 COX-2,还能抑制体外 H. pylori 的生长。 | |||
T2S0799 |
Noroxyhydrastinine
|
Tyrosinase | Proteases/Proteasome |
Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, TRP-1, and TRP-2 in α-MSH-stimulated B16 melanoma cells. | |||
TC0017 |
Haplopine
|
Tyrosinase; Antifection | Microbiology/Virology; Proteases/Proteasome |
Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells. | |||
TN7426 |
Ephedrannin A
|
Others | Others |
Ephedrannin A exhibits anti-melanogenesis and anti-inflammatory activities. | |||
TN1645 |
Flavokawain C
|
NADPH-oxidase; MAPK; AChR | Immunology/Inflammation; MAPK; Neuroscience |
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells. | |||
TN3723 |
Cryptomeridiol
|
PAFR; Antifection | GPCR/G Protein; Microbiology/Virology |
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM. | |||
TN1486 |
Chimonanthine
|
Others | Others |
(-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. | |||
TN3842 |
Diarylcomosol III
|
Others | Others |
Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders. | |||
TMA0003 |
Trans-caffeic acid
|
cAMP; Tyrosinase | GPCR/G Protein; Proteases/Proteasome |
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis. | |||
T81889 |
Machilin A
|
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Machilin A,作为一种木酚素类化合物,能从润楠树皮的甲醇提取物中分离提取。该化合物能有效抑制B-16小鼠黑色素瘤细胞的黑色素生物合成,其半抑制浓度(IC50)为39.9 μM。 | |||
T75554 |
6-O-Isobutyrylbritannilactone
|
Others | Others |
6-O-Isobutyrylbritannilactone 是一种天然的黑素生成抑制剂。6-O-Isobutyrylbritannilactone 是一种倍半萜,可从英菊花中分离得到。6-O-Isobutyrylbritannilactone 抑制 IBMX 诱导 B16F10 细胞产生黑色素。6-O-Isobutyrylbritannilactone 也调控 ERK、PI3K/AKT 和 CREB,在斑马鱼胚胎模型中显示出抗黑色素原活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00166 |
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel... |
Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... | |||
TMPH-00221 |
Agouti-signaling Protein, Bovine, Recombinant (His)
ASP,ASIP,Agouti-signaling protein,Agouti switch protein |
Bovine | Baculovirus Insect Cells |
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Agouti-signaling Protein, Bovine, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 14.9 kDa and the accession number is Q29414. | |||
TMPJ-00895 |
SCF Protein, Rat, Recombinant (HEK293, His)
steel factor,Mast cell growth factor,SLF,MGFSHEP7,SCFStem ce... |
Rat | HEK293 Cells |
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II... | |||
TMPJ-00894 |
SCF Protein, Rat, Recombinant (His)
Hematopoietic growth factor KL,Steel factor,Stem cell factor... |
Rat | E. coli |
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase... |