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Search Results for " inflamed "

Targets Recommended: P2X Receptor

9

抑制剂 & 化合物

1

天然产物

3

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T10466	BAY-1797	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	BAY-1797 是具有口服活性的选择性P2X4高效拮抗剂，对人 P2X4 的IC50为 211 nM，具有抗伤害和抗炎作用。
T15360	Furobufen	Others	Others
	Furobufen is an anti-inflammatory agent. It produces antiarthritic and has antipyretic effects. Furobufen also has an analgesic effect in inflamed tissue.
T69830	GSK2239633	Others	Others
	GSK2239633 is a potent CC-chemokine receptor 4 antagonist with pIC50 of 7.9. The CC-chemokine receptor 4 (CCR4) is thought potentially to play a critical role in asthma pathogenesis due to its ability to recruit type 2 T-helper lymphocytes to the inflamed airways. Therefore, CCR4 provides an excellent target for anti-inflammatory therapy.
T74975	Zn-DPA-maytansinoid conjugate 1	Others	Others
	Zn-DPA-maytansinoid conjugate 1 为一种靶向小分子免疫检查点的类美坦素偶联物。其能持续诱导肿瘤生长消退，并激活肿瘤微环境（TME），转化为“炎热肿瘤”。
T70616	ACT-672125	Others	Others
	ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.
T60957	Palmitoyl serinol	Others	Others
	Palmitoyl serinol (N-Palmitoyl serinol) 是内源性大麻素 N-棕榈酰乙醇胺(PEA) 的类似物，可改善正常和发炎皮肤的表皮通透性屏障。
T37389	NS 383	Others	Others
	ASIC blocker (IC50 values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50 value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50 values are 0.79, 0.87 and 4.5 uM at rat ASIC1a+3, ASIC1a+2a and ASIC2a+3; IC5O values are 0.33 and 0.69 uM at human ASIC1a+2a and ASIC1a+3, with no effect at ASIC2a+3). Attenuates pathophysiological nociceptive behaviors in CFA-inflamed and CCI rats.
T37606	Resolvin D5 7(S),17(S)-diHDHA	Others	Others
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.[3] RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in...
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1	Others	Others
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...

化合物

Cat.No: T10466

Target: P2X Receptor

Cat.No: T15360

Target: Others

Cat.No: T69830

Target: Others

Zn-DPA-maytansinoid conjugate 1

Cat.No: T74975

Target: Others

Cat.No: T70616

Target: Others

Palmitoyl serinol

Cat.No: T60957

Target: Others

Cat.No: T37389

Target: Others

Cat.No: T37606

Synonym: 7(S),17(S)-diHDHA

Target: Others

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2735	5-Acetylsalicylic acid 5-乙酰水杨酸(阿司匹林),5-acetyl-2-hydroxybenzoic acid	Others	Others
	5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) 是炎症性肠病中的活性剂，具有抗炎活性。

天然产物

5-Acetylsalicylic acid

Cat.No: T2735

Synonym: 5-乙酰水杨酸(阿司匹林),5-acetyl-2-hydroxybenzoic acid

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00380	AOC3 Protein, Human, Recombinant (His) Membrane primary amine oxidase,HPAO,VAP-1,Semicarbazide-sens...	Human	HEK293 Cells
	Vascular adhesion protein-1(VAP-1) is a copper amine oxidase with a topaquinone cofactor.VAP-1 is a type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. VAP-1 vascular expression is regulated at sites of inf...
TMPY-00493	IL-19 Protein, Human, Recombinant (His) interleukin 19,Interleukin-19,IL-10C,NG.1,ZMDA1,MDA1	Human	Baculovirus Insect Cells
	The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e...
TMPY-00564	MCP-4 Protein, Human, Recombinant (His) MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-...	Human	P. pastoris (Yeast)
	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem...

重组蛋白

AOC3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00380

Species: Human

Expression System: HEK293 Cells

IL-19 Protein, Human, Recombinant (His)

Cat.No: TMPY-00493

Species: Human

Expression System: Baculovirus Insect Cells

MCP-4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00564

Species: Human

Expression System: P. pastoris (Yeast)

Cat. No.	Product Name	Target	Signaling Pathways
T71288	Phenylbutazone-d9
	Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in...

同位素标记化合物

Phenylbutazone-d9

Cat.No: T71288

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