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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11469 |
GSK-3484862
|
DNA Methyltransferase | Chromatin/Epigenetic |
GSK-3484862 是 有效的 DNA 甲基转移酶 Dnmt1的非共价抑制剂。GSK-3484862 通过诱导 DNA 低甲基化起抗癌作用。GSK-3484862 介导小鼠胚胎干细胞的整体去甲基化。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00710 |
Claudin-4 Protein-VLP, Human, Recombinant
Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R |
Human | HEK293 Cells |
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in... |