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Cat. No. | Product Name | Target | Signaling Pathways |
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T35807 |
C18 dihydro Ceramide (d18:0/18:0)
C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0) |
Others | Others |
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in... | |||
T35806 |
N-Stearoylsphingosine
C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide |
Phosphatase | Metabolism |
N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物,通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性,导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。 | |||
T85162 |
(±)-2'-hydroxy Ceramide (d18:0/18:0)
(±)-2'-hydroxy Cer(d18:0/18:0) |
Others | Others |
(±)-2'-hydroxy Ceramide (d18:0/18:0)' 为一种鞘磷脂,能够自 ADP 刺激下的哺乳动物血小板中提取。 | |||
T37439 |
C18 Globotriaosylceramide (d18:1/18:0)
|
Others | Others |
C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma... | |||
T85186 |
C18 Sphingomyelin (d18:1/18:0)
SM(d18:1/18:0),Stearoyl Sphingomyelin,Sphingomyelin (d18:1/18:0),N-Octadecanoyl Sphingosylphosphorylcholine |
Others | Others |
T37457 |
C18 L-threo Ceramide (d18:1/18:0)
C18 L-threo Ceramide (d18:1/18:0) |
Others | Others |
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM). | |||
T38183 |
C18 3'-sulfo Galactosylceramide (d18:1/18:0)
C18 3'-sulfo Galactosylceramide (d18:1/18:0) |
Others | Others |
C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. Levels of short-chain sulfatides, including C18 3'-sulfo galactosylceramide, decrease with age in mice and humans. It is increased in brain from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions. Plasma levels of C18 3'-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability ... | |||
T37455 |
C18 D-threo Ceramide (d18:1/18:0)
C18 D-threo Ceramide (d18:1/18:0) |
Others | Others |
C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas... | |||
T37456 |
C18 L-erythro Ceramide (d18:1/18:0)
|
Beta Amyloid | Neuroscience |
C18 L-erythro Ceramide (d18:1/18:0)可显著降低细胞外 Aβ 水平,可用于研究阿尔茨海默病。 | |||
T37010 |
D-threo Sphinganine (d18:0)
D-threo Sphinganine (d18:0) |
Others | Others |
D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver. | |||
T85289 |
C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0)
((±)-2'-hydroxy) Cer(d18:1/18:0),((±)-2'-hydroxy) Ceramide (d18:1/18:0),18:0 (2R/S-OH)-Ceramide,N-(2'-(R,S)-hydroxystearoyl)-D-erythro-Sphingosine |
Others | Others |
T36987 |
N,N-dimethyl Sphinganine (d18:0)
N,N-dimethyl Sphinganine (d18:0) |
Others | Others |
N,N-dimethyl Sphinganine (d18:0) is a sphingolipid that increases during development ofL. donovanipromastigotes.1 1.Silva, A.M., Cordeiro-da-Silva, A., and Coombs, G.H.Metabolic variation during development in culture of Leishmania donovani promastigotesPLoS Negl. Trop. Dis.5(12)e1451(2011) | |||
T83880 |
C18 Ceramide-1-phosphate (d18:1/18:0) ammonium
Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate |
Others | Others |
C18 Ceramide-1-phosphate (d18:1/18:0) 是一种在鼠皮肤中发现的长链ceramide-1-phosphate。它能在0.5至5 µM的浓度范围内促进分离的小鼠骨髓来源的多能间充质细胞和人脐静脉内皮细胞(HUVECs)的迁移。与胰腺癌干细胞相比,CFPAC-1胰管腺癌细胞中C18 Ceramide-1-phosphate (d18:1/18:0)的水平有所增加。在Langendorff分离的灌流小鼠心脏的离体缺血模型中,心肌中C18 ceramide-1-phosphate (d18:1/18:0)的水平有所增加。 | |||
T85191 |
C6 Biotin Glucosylceramide (d18:1/6:0)
N-C6:0-Glucosylceramide-biotin,Biotin GluCer(18:1/6:0),N-Hexanoyl-biotin-Glucosylceramide,C6 Glucosylceramide-biotin,N-C6:0-β-D-Glucosylsphingosine-biotin,Biotin Glucosylceramide (d18:1/6:0) |
Others | Others |
T37563 |
C22 Ceramide (d18:1/22:0)
Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0) |
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C22 Ceramide (d18:1/22:0) (C22 Ceramide) 是一种从海绵Haliclona koremella 中分离出含有山嵛酸的长链神经酰胺,是一种内源性生物活性鞘脂。C22 Ceramide (d18:1/22:0) 可特异性抑制MCSR,降低离体大鼠肝线粒体和脂质体中 C16-神经酰胺通道的形成。 | |||
T35805 |
C16 Sphingomyelin (d18:1/16:0)
Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin |
Endogenous Metabolite | Metabolism |
C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物,可用于研究生物膜的活性。 | |||
T85165 |
EOS (d18:1/30:0/18:2)
C48:2 EOS (d18:1/30:0w18:2 (9Z,12Z)),N-(30-linoleoyloxy-triacontanoyl)-Sphingosine |
Others | Others |
T35810 |
C24 dihydro Ceramide (d18:0/24:0)
Cer(d18:0/24:0) |
Others | Others |
C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squam... | |||
T85279 |
C17 dihydro Ceramide (d18:0/17:0)
N-heptadecanoyl-D-erythro-Dihydrosphingosine,Cer(d18:0/17:0),Ceramide (d18:0/17:0) |
Others | Others |
T36860 |
C22 Sphingomyelin (d18:1/22:0)
C22 Sphingomyelin (d18:1/22:0) |
Others | Others |
C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin . | |||
T37438 |
C17 Globotriaosylceramide (d18:1/17:0)
C17 Globotriaosylceramide (d18:1/17:0) |
Others | Others |
C17 Globotriaosylceramide is a sphingolipid that has been used as an internal standard for the quantification of globotriaosylceramides in plasma and urine from patients with Fabry disease by GC-MS. | |||
T84383 |
C2 dihydro Ceramide (d18:0/2:0)
Cer(d18:0/2:0),N-acetyl-D-erythro-Sphinganine,N-acetyl-dihydro-Sphingosine,Ceramide (d18:0/2:0),N-acetyl-D-erythro-dihydro-Sphingosine |
Others | Others |
T85187 |
C6 dihydro Ceramide (d18:0/6:0)
Ceramide (d18:0/6:0),Cer(d18:0/6:0),N-hexanoyl-D-erythro-Dihydrosphingosine |
Others | Others |
T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
Others | Others |
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m... | |||
T37564 |
C4 Ceramide (d18:1/4:0)
C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0) |
Others | Others |
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing... | |||
T36859 |
C16 Globotriaosylceramide (d18:1/16:0)
C16 Globotriaosylceramide (d18:1/16:0) |
Others | Others |
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien... | |||
T37872 |
C16 Galactosylceramide (d18:1/16:0)
C16 Galactosylceramide (d18:1/16:0) |
Others | Others |
C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid . | |||
T36858 |
C12 Galactosylceramide (d18:1/12:0)
|
Others | Others |
C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus. | |||
T38282 |
C22 Glucosylceramide (d18:1/22:0)
|
Others | Others |
C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide (d18:1/22:0) expression in rat brain. It is also increased in the brain, but not the liver or spinal cord, of mice f... | |||
T38286 |
C26 Sphingomyelin (d18:1/26:0)
C26 Sphingomyelin (d18:1/26:0) |
Others | Others |
C26 Sphingomyelin is a sphingolipid that has been found in serum and cell or brain extracts.1,2,3C26 sphingomyelin levels are increased in the serum of patients with hemophagocytic lymphohistiocytosis, an inflammatory condition characterized by excessive immune activation.3C26 sphingomyelin has been used a component of monolayers to study the influence of sphingomyelin acyl chain length on sphingomyelin-sterol interactions.4[Matreya, LLC.] 1.Wang, J.-R., Zhang, H., Yau, L.D., et al.Improved sphi... | |||
T37437 |
C17 Ceramide (d18:1/17:0)
|
Others | Others |
C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy. | |||
T36323 |
C8 Galactosylceramide (d18:1/8:0)
C8 Galactosylceramide (d18:1/8:0) |
Others | Others |
C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo.... | |||
T35873 |
C19 Ceramide (d18:1/19:0)
C19 Ceramide (d18:1/19:0) |
Others | Others |
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3] | |||
T38281 |
C22 Galactosylceramide (d18:1/22:0)
|
Others | Others |
C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2[Matreya, LLC.] | |||
T38011 |
C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)
|
Others | Others |
C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. It inhibits Vero toxin binding to globotriaosylceramide in an ELISA assay when used at a concentration of 10 μM. AdaGb3 decreases cell surface expression of P-glycoprotein (P-gp) and reduces efflux of rhodamine 123 in MDCK cells. It also increases apical-to-basal transport of vinblastine in human intestinal ... | |||
T85276 |
C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0)
N-(R,S)-α-hydroxydodecanoyl-D-erythro-Dihydrosphingosine,(±)-2'-hydroxy Cer(d18:0/12:0),(±)-2'-hydroxy Ceramide (d18:0/12:0) |
Others | Others |
T85161 |
N,N-dihexyl Sphingosine (d18:1/6:0/6:0)
N,N-dihexyl-D-erythro-Sphingosine |
Others | Others |
T85175 |
C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0)
N-(R,S)-α-hydroxyhexadecanoyl-D-erythro-Dihydrosphingosine,(±)-2'-hydroxy Ceramide (d18:0/16:0) |
Others | Others |
T35804 |
C16 Lactosylceramide (d18:1/16:0)
|
Others | Others |
C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. | |||
T38181 |
C17 Lactosylceramide (d18:1/17:0)
|
Others | Others |
C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue. | |||
T38182 |
C17 Sphingomyelin (d18:1/17:0)
C17 Sphingomyelin (d18:1/17:0) |
Others | Others |
C17 Sphingomyelin is a synthetic derivative of sphingomyelin that has been used as an internal standard for the quantification of sphingomyelin. | |||
T37440 |
C2 Adamantanyl Galactosylceramide (d18:1/2:0)
|
Others | Others |
C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. | |||
T36140 |
BODIPY-C12 Ceramide (d18:1/12:0)
BODIPY-C12 Ceramide (d18:1/12:0) |
Others | Others |
BODIPY-C12 Ceramide(B12Cer)是C12鞘氨醇的荧光标记形式,其激发/发射最大值分别为505/540 nm。BODIPY-C12 Ceramide 是一种带有荧光标记的神经酰胺。BODIPY-C12 Ceramide已被用于量化尼曼-匹克病患者血浆中酸性鞘磷脂酶的活性。 | |||
T85065 |
C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0)
(R)-2'-hydroxy Ceramide (d18:0/24:0),N-(R)-α-C24 dihydro Ceramide (d18:0/24:0),N-(R)-α-hydroxytetracosanoyl-D-erythro-Dihydrosphingosine,(R)-2'-hydroxy Cer(d18:0/24:0) |
Others | Others |
T36322 |
C8 D-threo Ceramide (d18:1/8:0)
C8 D-threo Ceramide (d18:1/8:0) |
Others | Others |
C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r... | |||
T38185 |
C2 3'-sulfo Galactosylceramide (d18:1/2:0)
C2 3'-sulfo Galactosylceramide (d18:1/2:0) |
Others | Others |
C2 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been used as an internal standard in the quantification of lysosulfatides in mouse brain tissue and plasma. | |||
T36319 |
C6 L-erythro Ceramide (d18:1/6:0)
C6 L-erythro Ceramide (d18:1/6:0) |
Others | Others |
C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM). | |||
T85275 |
C32 Ceramide (d18:1/32:0)
Cer(d18:1/32:0),N-dotriacontanoyl-D-erythro-Sphingosine,Ceramide (d18:1/32:0) |
Others | Others |
T85193 |
C10 Ceramide (d18:1/10:0)
Ceramide (d18:1/10:0),N-decanoyl-D-erythro-Sphingosine,C10 Ceramide,Cer(d18:1/10:0) |
Others | Others |
T85189 |
C15 Ceramide (d18:1/15:0)
Ceramide (d18:1/15:0),N-pentadecanoyl-D-erythro-Sphingosine,Cer(d18:1/15:0) |
Others | Others |
Cat. No. | Product Name | Target | Signaling Pathways |
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T41338 |
C30(ω-hydroxy) Ceramide (d18:1/30:0)
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C30(ω-hydroxy) Ceramide (d18:1/30:0) 在生命科学相关研究中具有广泛的应用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T36149 |
13C C16 Sphingomyelin (d18:1/16:0)
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13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or... |