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Search Results for " cyclosome "
Targets Recommended: APC

1

抑制剂 & 化合物

1

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T8561 Apcin

APC Cell Cycle/Checkpoint
Apcin 是后期促进复合物/环体 (APC/C(Cdc20)) E3 连接酶活性的有效竞争性抑制剂,可通过与 Cdc20 结合并阻止底物识别竞争性地抑制 APC/C 依赖性泛素化。它占据 WD40 结构域侧面的 D-box 结合口袋,并可以延长有丝分裂。它通过阻断有丝分裂退出并通过共同添加 Ts-Arg-OMe 协同放大而起作用。

化合物

Apcin
Cat.No: T8561
Synonym:
Target: APC
Cat. No. Product Name Species Expression System
TMPJ-01138 UBE2S Protein, Human, Recombinant (GST)

UBE2S,Ubiquitin-Conjugating Enzyme E2-24 kDa,E2-EPF,E2EPF,Ub...

Human E. coli
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiqui...

重组蛋白

UBE2S Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01138
Species: Human
Expression System: E. coli
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