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Search Results for " cell-penetration "

Targets Recommended: Histone Methyltransferase

16

抑制剂 & 化合物

2

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2354	UNC 0631 UNC0631	Histone Methyltransferase	Chromatin/Epigenetic
	UNC 0631 是一种有效的组蛋白甲基转移酶 G9a 抑制剂，IC50值为 4 nM。它有效降低 MDA-MB-231 细胞中 H3K9me2的水平，IC50为 25 nM。
TQ0232	UNC0646 UNC 0646	Histone Methyltransferase	Chromatin/Epigenetic
	UNC0646 是一种有效的、选择性的同源蛋白赖氨酸甲基转移酶 G9a 和 GLP 抑制剂，IC50分别为 6 和 15 nM，对 G9a/GLP 的选择性比 SETD7、SUV39H2、SETD8 和 PRMT3 高。它降低 MDA-MB-231 细胞中H3K9me2的水平，IC50为 26 nM。
TP2505L	LAH4 acetate KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)	Antibacterial	Microbiology/Virology
	LAH4 acetate 是所设计的两性肽抗生素的α -螺旋结构，能够与DNA 络合，与细胞表面膜结合后被包裹在核内体中，随着pH 值的下降破坏核内体膜。具有强大的抗菌、核酸转染和细胞渗透活性。LAH4 acetate 具有较高的质粒DNA 传递能力。LAH4 acetate 对细菌膜外膜中的阴离子脂具有很强的亲和力。
T11797	L-690488	Others	Others
	L-690488 has more effective cell penetration than L-690330. L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor.
T61701	SHP2-IN-9	Others	Others
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1].
T60970	Caprochlorone	Others	Others
	Caprochlorone 对正痘病毒具有抗病毒活性，可以降低被感染的小鼠肺部中流感病毒的滴度。Caprochlorone 可以抑制病毒穿透细胞，并且延迟新形成的病毒从细胞释放。
T17454	ATP-polyamine-biotin	Others	Others
	ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling
T68547	SNJ-1945	Others	Others
	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin a...
T81526	Pegsebrenatide NLY01
	Pegsebrenatide (NLY01) 是一种具有扩展半衰期和优良血脑屏障穿透能力的长效GLP-1R激动剂。该化合物能够抑制A1型星形胶质细胞的活化，降低多巴胺能神经元凋亡，并在帕金森病（PD）小鼠模型中改善运动功能障碍。
T82010	JDB175	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	JDB175是一种具有口服活性的高选择性BTK抑制剂，能够有效穿透血脑屏障。在中枢神经系统淋巴瘤的小鼠模型中，JDB175显示出良好的抗肿瘤活性，并未观察到显著毒性。它能有效地抑制人淋巴瘤细胞的BTK信号通路，阻止细胞周期，促进细胞凋亡。
T75762	LAH4 TFA
	LAH4 TFA是一种两亲性肽抗生素，以α螺旋形式表现出显著的抗菌(antimicrobial)、核酸转染(nucleic acid transfection)及细胞穿透能力。它在传递质粒DNA方面显示出较高效能，并对细菌外膜中的阴离子脂质展现强烈亲和力。
T71577	KOS-1584	Others	Others
	KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration,...
T61388	hAChE/Aβ1-42-IN-1	Others	Others
	hAChE/Aβ1-42-IN-1 (Compound 16) 是一种有效的 hAChE 和 Aβ1-42聚集抑制剂。hAChE/Aβ1-42-IN-1 对 hepG2 细胞系显示出可接受的相对安全性，并具有良好的 BBB 渗透性和较宽的安全范围。hAChE/Aβ1-42-IN-1具有研究阿尔茨海默病 (AD) 的潜力。
T68860	Iso-Fludelone	Others	Others
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...
T85192	AF-353 hydrochloride P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353	Others	Others
	This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 µM) in cell lines that express human P2X3 and P2X2/3 receptors recombinantly. The ...
T84871	Emetine hydrochloride NSC 33669	Others	Others
	Emetine hydrochloride (NSC 33669)，一种从ipecac根部提取的生物碱，用于临床上作为催吐及抗原生动物药物。它能够降低HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α)、PDK1、RhoA、Rho-kinases (ROCK1 and ROCK2)和BRD4，抑制细胞自噬，并展现抗疟疾、抗病毒、抗细菌及抗变形虫效果。

化合物

Cat.No: T2354

Synonym: UNC0631

Target: Histone Methyltransferase

Cat.No: TQ0232

Synonym: UNC 0646

Target: Histone Methyltransferase

Cat.No: TP2505L

Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Target: Antibacterial

Cat.No: T11797

Target: Others

Cat.No: T61701

Target: Others

Cat.No: T60970

Target: Others

ATP-polyamine-biotin

Cat.No: T17454

Target: Others

Cat.No: T68547

Target: Others

Cat.No: T81526

Synonym: NLY01

Cat.No: T82010

Target: BTK

Cat.No: T75762

Cat.No: T71577

Target: Others

hAChE/Aβ1-42-IN-1

Cat.No: T61388

Target: Others

Cat.No: T68860

Target: Others

AF-353 hydrochloride

Cat.No: T85192

Synonym: P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353

Target: Others

Emetine hydrochloride

Cat.No: T84871

Synonym: NSC 33669

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4820	Maleimide 马来酰亚胺,2,5-Pyrroledione	Others	Others
	Maleimide (2,5-Pyrroledione) 可用于制备荧光探针，主要用于硫醇分析物的特异性检测。它也可用于制备用于癌症研究的抗体-药物偶联物 (ADC)。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit

天然产物

Cat.No: T4820

Synonym: 马来酰亚胺,2,5-Pyrroledione

Target: Others

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01813	ACRV1 Protein, Human, Recombinant (His) SP-10,SPACA2,D11S4365,acrosomal vesicle protein 1	Human	HEK293 Cells
	Acrosomal protein SP-1, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. Regulation of cell type-specific gene transcription is central to cellular differentiation and development. During spermatogenesis, a number of testis-specific genes are expressed in a precise spatiotemporal order. The longest tr...
TMPH-03676	Vaccinia virus (strain Western Reserve) L1 Protein (His) Entry-fusion complex associated protein OPG095,EFC-associate...	VACV	P. pastoris (Yeast)
	Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Western Reserve) L1 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P07612.
TMPH-03675	Vaccinia virus (strain Western Reserve) L1 Protein (E. coli, His) Entry-fusion complex associated protein OPG095,EFC-associate...	VACV	E. coli
	Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Western Reserve) L1 Protein (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.8 kDa and the accession number is P07612.
TMPH-03673	Vaccinia virus (strain Copenhagen) L1 Protein (His & Myc) EFC-associated protein OPG095,Entry-fusion complex associate...	VACV	Baculovirus Insect Cells
	Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Copenhagen) L1 Protein (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 23.2 kDa and the accession number is P20540.
TMPH-00521	G3P Protein, Enterobacteria phage M13, Recombinant (His) Minor coat protein,Gene 3 protein,III,Attachment protein G3P	Enterobacteria phage M13	P. pastoris (Yeast)
	Plays essential roles both in the penetration of the viral genome into the bacterial host via pilus retraction and in the extrusion process. During the initial step of infection, G3P mediates adsorption of the phage to its primary receptor, the tip of host F-pilus. Subsequent interaction with the host entry receptor tolA induces penetration of the viral DNA into the host cytoplasm. In the extrusion process, G3P mediates the release of the membrane-anchored virion from the cell via its C-terminal...
TMPH-00782	OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO) Outer membrane porin A,Outer membrane protein P5,Outer membr...	Haemophilus influenzae	E. coli
	Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.
TMPH-02377	OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc) Outer membrane protein 3A,Outer membrane protein A,ompA,Oute...	Klebsiella pneumoniae	E. coli
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.; Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells.
TMPH-03674	Vaccinia virus (strain Copenhagen) L1 Protein (E. coli, His & Myc) Virion membrane protein M25,OPG099,Protein L1,Entry-fusion c...	VACV	E. coli
	Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Copenhagen) L1 Protein (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.8 kDa and the accession number is P20540.
TMPH-03426	Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His) Hemagglutinin,Outer capsid protein VP4	RVX	P. pastoris (Yeast)
	Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. It is subsequently lost, together with VP7, following virus entry into the host cell. Following entry into the host cell, low intracellular o...
TMPH-02345	Influenza A H1N1 (train A/Hickox/1940) Hemagglutinin/HA Protein (His & SUMO) HA,Hemagglutinin	H1N1	E. coli
	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the e...
TMPH-03472	OmpA Protein, Salmonella typhi, Recombinant (His) Outer membrane porin A,Outer membrane protein A,ompA	Salmonella typhi	E. coli
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.; Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. OmpA Protein, Salmonella typhi, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 38.9 kDa an...
TMPH-00674	OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO) ompA,Outer membrane protein A,Outer membrane porin A	E. coli	E. coli
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.; Required for conjugation with F-type plasmids; probably serves as the mating receptor on recipient cells. OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is ...

重组蛋白

ACRV1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01813

Species: Human

Expression System: HEK293 Cells

Vaccinia virus (strain Western Reserve) L1 Protein (His)

Cat.No: TMPH-03676

Species: VACV

Expression System: P. pastoris (Yeast)

Vaccinia virus (strain Western Reserve) L1 Protein (E. coli, His)

Cat.No: TMPH-03675

Species: VACV

Expression System: E. coli

Vaccinia virus (strain Copenhagen) L1 Protein (His & Myc)

Cat.No: TMPH-03673

Species: VACV

Expression System: Baculovirus Insect Cells

G3P Protein, Enterobacteria phage M13, Recombinant (His)

Cat.No: TMPH-00521

Species: Enterobacteria phage M13

Expression System: P. pastoris (Yeast)

OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00782

Species: Haemophilus influenzae

Expression System: E. coli

OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc)

Cat.No: TMPH-02377

Species: Klebsiella pneumoniae

Expression System: E. coli

Vaccinia virus (strain Copenhagen) L1 Protein (E. coli, His & Myc)

Cat.No: TMPH-03674

Species: VACV

Expression System: E. coli

Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His)

Cat.No: TMPH-03426

Species: RVX

Expression System: P. pastoris (Yeast)

Influenza A H1N1 (train A/Hickox/1940) Hemagglutinin/HA Protein (His & SUMO)

Cat.No: TMPH-02345

Species: H1N1

Expression System: E. coli

OmpA Protein, Salmonella typhi, Recombinant (His)

Cat.No: TMPH-03472

Species: Salmonella typhi

Expression System: E. coli

OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO)

Cat.No: TMPH-00674

Species: E. coli

Expression System: E. coli

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