bis peg2 pfp ester

Bis-PEG2-PFP ester is a non-cleavable 2-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs) [1]. Additionally, Bis-PEG2-PFP ester serves as a PEG-based linker for the synthesis of proteolysis targeting chimeras (PROTACs) [2].

1,2-Bis(2-iodoethoxy)ethane 是一种属于 PEG 类的 PROTAC linker，可用于 MT802 和 SJF620 的合成。其中 MT-802 和 SJF620 都是 PROTAC BTK 降解剂，DC50分别为 1 和 7.9 nM。

Propargyl-PEG5-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly utilized in PROTAC technology. This compound acts as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Propargyl-PEG2-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis[1].

Bis-PEG4-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hydroxy-PEG2-C2-PFP ester, a PEG Alkyl ether-based PROteolysis TArgeting Chimeric (PROTAC) linker, is suitable for the synthesis of PROTACs.

NHPI-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker commonly employed in antibody-drug conjugate (ADC) synthesis.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker. This specific linker is utilized in the synthesis of PROTACs, or proteolysis targeting chimeras [1].

Bis-PEG2-endo-BCN is a two-unit cleavable polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Mal-PEG4-PFP ester is a non-cleavable antibody-drug conjugate (ADC) linker that incorporates a Maleimide moiety, a 4-unit Polyethylene Glycol (PEG) backbone, and a Pentafluorophenyl (PFP) ester.

Bis-PEG5-NHS ester, a cleavable ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1].

N-DBCO-N-bis(PEG2-C2-NHS ester) is a Polyethylene Glycol (PEG) derived linker that finds utility in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

NH-bis(PEG2-C2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-(Azido-PEG4)-N-bis(PEG4-t-butyl ester) is a polyethylene glycol (PEG)-based linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs).

N-(t-Boc-Aminooxy-PEG2)-N-bis(PEG3-propargyl) is a polyethylene glycol (PEG) derivative specifically designed as a linker for PROTAC synthesis [1].

N-Boc-N-bis(PEG2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG7-NHS ester is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) [1].

Hydroxy-Amino-bis(PEG2-propargyl) is a PEG-linked PROTAC linker employed for synthesizing PROTACs[1].

Mal-amido-PEG2-NHS ester is a noncleavable linker for antibody-drug conjugates (ADCs) that consists of a maleimide group and an NHS ester. The NHS ester allows for the labeling of protein primary amines (-NH2), amine-modified oligonucleotides, and other amine-containing molecules[1][2].

Mal-PEG2-NHS ester is a noncleavable antibody-drug conjugate linker comprising a Maleimide moiety, a 2-unit PEG spacer, and an N-hydroxysuccinimide (NHS) ester functionality.

Bis-PEG2-NHS ester, utilized in antibody-drug conjugation (ADC), functions as a non-cleavable linker with two polyethylene glycol (PEG) units.

N3-PEG3-C2-PFP ester is a 3-unit polyethylene glycol (PEG) linker devoid of cleavable bonds. It is commonly employed in the synthesis of antibody-drug conjugates (ADCs).

Endo-BCN-PEG2-PFP ester, a PEG-based linker, serves as a valuable component in PROTAC synthesis[1].

Biotin-PFP ester, an alkyl ether-based PROTAC linker, serves as a valuable component in the synthesis of PROTACs[1].

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker utilized in the synthesis of PROTACs[1].

6-Maleimidocaproic acid-PFP ester is a hydrocarbon-based PROTAC linker, suitable for the synthesis of PROTACs[1].

Hydroxy-PEG2-C2-methyl ester is a polyethylene glycol (PEG)-based linker commonly employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Acid-PEG3-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.

Mal-PEG5-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG4-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis2-bromoethyl ether is an alkyl chain-derived PROTAC linker, facilitating the synthesis of PROTACs.

Bis-PEG3-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-PEG7-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

rm-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

Mal-amido-PEG2-TFP ester is a polyethylene glycol (PEG)-based linker with amide functionality and trifluorophenyl (TFP) ester group. It finds application in PROTAC synthesis as a PEG-based PROTAC linker[1].

endo-BCN-PEG2-C2-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Mal-N-bis(PEG2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Endo-BCN-PEG4-PFP ester is a polyethylene glycol (PEG) derivative, specifically designed as a linker for proteolysis-targeting chimeras (PROTACs) [1].

N-Desthiobiotin-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG) derived linker used for synthesizing PROTACs[1].

DBCO-(PEG2-Val-Cit-PAB)2 is a dual-cleavable linker used in antibody-drug conjugates (ADCs).

Azido-PEG1-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

C-NH-Boc-C-Bis-(C1-PEG1-PFP) is a polyethylene glycol (PEG)-derived PROTAC linker, which finds application in the synthesis of PROTACs[1].

N-Mal-N-bis(PEG2-C2-Boc) is a polyethylene glycol (PEG)-based linker for proteolysis targeting chimeras (PROTACs)[1].