ac-lys-amc

Ac-Lys-AMC (Hexanamide) is a fluorescent substrate for histone deacetylase HDACs.

Ac-RGK(Ac)-AMC, fluorogenic substrate for assaying histone deacetylase (HDAC) activity in a two-step enzymatic reaction. The assay consists of the initial lysine deacetylation by HDAC followed by the release of the fluorescent group by trypsin.

Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1] Commendamide and structurally related endogenous long-chain N-Acyl-amides activates discrete human receptors. In a screen for agonist activity against a library of 242 GPCRs, commendamide is found to activate a single receptor G2A/GPR132. This activity is confirmed by a synthetic sample of commendamide. Commendamide analogs with changes in the head group or acyl chain also exhibited reduced GPR132/G2A activity. [1]

Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) 是一种 Caspase-3底物。

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 是一种血清稳定化合物，能够选择性地抑制 tau 蛋白的纤维化，并且对神经细胞无毒。

Ac-Lys-OMe.HCl 是一种氨基酸衍生物，在生命科学相关研究中具有广泛的应用。

Ac-Leu-Arg-AMC (Acetyl-Leucyl-Arginyl-7-amido-4-methylcoumarin) is a fluorogenic peptide substrate.

Ac-YVAD-AMC 是一种 caspase 抑制剂，能够抑制由细菌诱导和过敏反应引发的细胞死亡。

Ac-DMQD-AMC, an inhibitor of caspase-3, is an aromatic amine synthesized using the aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) [1].

Substrate for dengue virus NS2B-NS3 and yellow fever virus NS3 protease. The kcat/Km value of Bz-NleKRR-AMC for the dengue virus type 4 (DEN4) enzyme is > 800 fold higher than that of Boc-Gly-Arg-Arg-AMC, a widely used NS3 substrate (kcat = 2.9 s 1, Km = 8.6 μM for DEN4). For yellow fever virus NS3 protease the kcat value was 0.111 s 1, the Km value 14.6 μM.

Ac-Phe-Lys-OH是一种人工合成的氨基酸肽类甜味剂，具有阿斯巴甜类似的甜度。

Ac-Tyr-Val-Lys-Asp-aldehyde，一种caspase-1抑制剂，适用于慢性疾病相关贫血、化疗诱导贫血及钻石黑扇贫血的研究。

Ac-Nle-Pro-Nle-Asp-AMC 是26S 蛋白酶体(26Sproteasome)的特异性底物，适用于分析26S 蛋白酶体中caspase样活性。

Ac-PAL-AMC is a fluorogenic substrate for the β1i LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β1i LMP2 subunit of the 20S immunoproteasome. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation emission maxima of 351 430 nm, respectively.

Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm. 1.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9677-9682(1997) 2.Chae, H.J., Park, K.M., Lee, G.Y., et al.Je-Chun-Jun induced apoptosis of human cervical carcinoma HeLa cellsActa Pharmacologica Sinica25(10)1372-1379(2004)

Pyr-Arg-Thr-Lys-Arg-AMC TFA为AMC肽类化合物，其结构由十肽组成，可经由特异性水解反应由如胰蛋白酶及凝血酶等蛋白酶作用下分解。该肽用于评估蛋白酶活性及酶抑制剂功效的检测。

Ac-Leu-Val-Lys-Aldehyde 是有效的组织蛋白酶 B (cathepsin B) 抑制剂，其 IC50 值为 4 nM。该化合物能显着降低喹啉酸引起的纹状体细胞死亡，并促使 LC3-II 积累。

'(Ac)Phe-Lys(Alloc)-PABC-PNP serves as a valuable cleavable linker in the development of antibody-drug conjugates.'

Ac-Lys-Val-Cit-PABC-MMAE (formic) 为一种抗体药物偶联物（ADC）的活性组分。该化合物是由ADC链接子（肽类Ac-Lys-Val-Cit-PABC）与微管蛋白聚合抑制剂Monomethylauristatin E (MMAE) 结合而得。

Ac-Lys-Val-Cit-PABC-MMAE作为一种抗体偶联药物(ADC)的活性分子部分，由ADC连接子（肽 Ac-Lys-Val-Cit-PABC）与微管蛋白聚合抑制剂MMAE经偶联形成。

Fmoc-Lys(Ac)-OH 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65778，CAS号为 159766-56-0。

Ac-LEHD-AMC is a fluorogenic substrate for caspase-9.[1] Upon cleavage by caspase-9, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-9 activity. AMC displays excitation emission maxima of 340-360 440-460 nm, respectively.

Ac-Trp-Glu-His-Asp-AMC (AC-WEHD-AMC) 是caspase-1的有效荧光底物。