mpeg6c6phosphonic acid ethyl ester

m-PEG6-C6-phosphonic acid ethyl ester serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) 用作 PROTAC linker。

6-Maleimidocapronic acid 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Phthalimidinoglutarimide-6-piperazine 是一种 E3 泛素连接酶配体-Linker 的偶联物，用于合成完整的 PROTACs 分子。

m-PEG6-(CH2)6-Phosphonic acid serves as a PEG-based PROTAC linker for synthesizing PROTACs[1].

C2-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker utilized for the synthesis of PROTACs[1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation.

Acid-PEG3-mono-methyl ester, an alkyl ether-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Mal-NH-ethyl-SS-propionic acid, a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1], plays a crucial role in the modulation of drug release from the conjugate.

Acid-PEG13-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG3-phosphonic acid is a PEG-based linker compound utilized in PROTAC synthesis[1].

Acid-PEG25-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG4-(CH2)6-Phosphonic acid is a polyethylene glycol-based linker compound, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG3-phosphonic acid ethyl ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

PEG3-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derived linker specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG3-aminoacetic acid-NHS ester is a PEGylation-based linker for the development of PROTACs[1]. It can be utilized in the synthesis of PROTACs, offering a versatile and efficient approach.

m-PEG9-phosphonic acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

The compound [10-(diethoxy-phosphoryl)-decyl]-phosphonic acid is a suitable alkyl chain-based PROTAC linker for the synthesis of PROTACs [1].

(10-BRomodecyl)phosphonic acid is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis [1].

cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1].

Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516

3-Mercaptopropionic acid NHS ester 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64663。

PROTACCDK9 degrader-6 是靶向CDK9的特异性PROTAC分子，能通过蛋白酶体介导的机制实现CDK9的降解。该化合物针对CDK942与CDK955异构体的DC50分别为0.03 μM和0.05 μM。

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64585。

PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).

S-acetyl-PEG3-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Acid-C2-PEG3-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].

Bromo-PEG3-C2-phosphonic acid is a polyethylene glycol (PEG) derivative serving as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

m-PEG8-(CH2)12-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based PROTAC linker, suitable for the synthesis of PROTAC compounds[1].

Acid-C2-PEG4-C2-NHS ester, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

β-Estradiol-6-CMO-PEG3-biotin serves as a cleavable 3-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs)[1].

Acid-PEG9-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG2-bis(phosphonic acid) is a PEG Linker.

m-PEG2-phosphonic acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG9-phosphonic acid ethyl ester, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Bromo-PEG2-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

m-PEG4-C6-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based linker compound utilized for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

m-PEG8-C10-phosphonic acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG2-bis(phosphonic acid diethyl ester) is a polyethylene glycol (PEG) derivative commonly employed as a linker in proteolysis-targeting chimeras (PROTACs) synthesis[1].

HEMTAC CDK4 6 degrader 1 是一种通过连接HSP90的配体和CDK4 6而形成的PROTAC，其Kd值为35.7 µM。在B16F10黑色素瘤细胞中，该化合物能够诱导CDK4 6的降解，从而将细胞周期阻滞在G0 G1期，并引发细胞凋亡。因此，HEMTAC CDK4 6 degrader 1可被应用于癌症研究领域。

PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1].

Boc-6-aminohexanoic acid is an alkyl ether-based linker employed in PROTAC synthesis.

Pomalidomide-6-O-CH3 is a Pomalidomide-derived ligand for cereblon (CRBN), which serves as a linkage agent to recruit the CRBN protein. This ligand, when connected to a protein via a linker, enables the formation of PROTAC.

m-PEG3-phosphonic acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

C6-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker suitable for PROTAC synthesis[1].

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived PROTAC linker employed for the synthesis of PROTACs[1].

Propargyl-PEG3-phosphonic acid diethyl ester, a PEG-based PROTAC linker, is employed for the synthesis of PROTACs[1].