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WYC-209

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产品编号 T5341Cas号 2131803-90-0
别名 WYC209

WYC-209 是一种合成类视黄醇,是维甲酸受体激动剂。它主要通过 caspase 3途径抑制恶性鼠黑色素瘤肿瘤再生细胞的增殖,IC50值为 0.19 μM。

WYC-209
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WYC-209

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纯度: 99.77%
产品编号 T5341 别名 WYC209Cas号 2131803-90-0

WYC-209 是一种合成类视黄醇,是维甲酸受体激动剂。它主要通过 caspase 3途径抑制恶性鼠黑色素瘤肿瘤再生细胞的增殖,IC50值为 0.19 μM。

规格价格库存数量
1 mg¥ 248现货
5 mg¥ 578现货
10 mg¥ 913现货
25 mg¥ 1,890现货
50 mg¥ 2,970现货
100 mg¥ 4,580现货
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产品介绍

生物活性
产品描述
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).
靶点活性
TRC:0.19 μM
体外活性
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs), with an IC50 of 0.19?μM in a dose-dependent manner. WYC-209 also inhibits proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.
体内活性
WYC-209 abrogates 87.5% of lung metastases of melanoma TRCs in immune-competent wild-type C57BL/6 mice at 0.22?mg?kg-1 without showing apparent toxicity.
细胞实验
Cell proliferation rate was measured by using MTT colorimetric assay. Cells were seeded in 3D soft fibrin gel in 96-well microplates at a density to maintain control (untreated) cells in an exponential phase of growth during the entire experiment. Cells were incubated with various concentrations of compounds for each time point followed by incubation with 50?μL MTT reagent for 3?h at 37?°C. After incubation, 150?μL MTT solvent was added and absorbance was measured at 570?nm. All experiments were repeated at least three times. The percentage of viable cells was calculated and averaged for each well: percent growth?=?(OD-treated cells/OD control cells)?×?100, cell proliferation at each time point is normalized to base line cell survival at the time of initial compound treatment (day 0).
动物实验
Four- to six-week-old female and male C57BL/6 mice were used in mice experiment. Mice were randomized into different groups. In metastasis experiment, B16-F1 cell spheroids were selected from 3D 90-Pa fibrin gels and pipetted to single cells. These TRCs were harvested and the cell number was counted under microscopy. The cells were then suspended in PBS with appropriate cell density. Thirty thousand TRCs were intravenously injected into the tail vein of each wild-type C57BL/6 mouse. Five days later, inoculated mice were intravenous implanted with 0.022?mg/kg WYC-209, 0.22?mg/kg WYC-209, or 0.1% DMSO every two days. The mice were euthanized and examined for lung tumor formation at day 30. In treated TRCs injected in vivo experiments, B16-F1 cells were seeded into 3D 90-Pa fibrin gels and treated with 10?μM WYC-209 or 0.1% DMSO on day 3, then isolated treated TRCs colonies on day 5 and pipetted into single cell. 30,000 of TRCs were intravenously injected into the tail vein of each wild-type C57BL/6 mouse. No blinding was performed in the mice experiments.
别名WYC209
化学信息
分子量368.45
分子式C20H20N2O3S
CAS No.2131803-90-0
SmilesCCOC(=O)c1cnc(nc1)C#Cc1ccc2c(c1)C(C)(C)CCS2=O
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 80 mg/mL (217.13 mM)
H2O: Insoluble
溶液配制表
1mg5mg10mg50mg
1 mM2.7141 mL13.5704 mL27.1407 mL135.7036 mL
5 mM0.5428 mL2.7141 mL5.4281 mL27.1407 mL
10 mM0.2714 mL1.3570 mL2.7141 mL13.5704 mL
20 mM0.1357 mL0.6785 mL1.3570 mL6.7852 mL
50 mM0.0543 mL0.2714 mL0.5428 mL2.7141 mL
100 mM0.0271 mL0.1357 mL0.2714 mL1.3570 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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