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TMPJ-00412
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VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme...
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Human
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HEK293 Cells
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Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... |
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TMPH-00949
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APOLD1 Protein, Human, Recombinant (His)
Vascular early response gene protein,APOLD1,VERGE,Apolipopro...
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Human
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E. coli
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May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability. APOLD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 33.4 kDa and the accession number is Q96LR9. |
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TMPH-02861
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Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)
Wnt7b,Protein Wnt-7b
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Mouse
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E. coli
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Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. |
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TMPH-03373
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SLC2A1 Protein, Rat, Recombinant (His & Myc)
Glucose transporter type 1, erythrocyte/brain,Solut...
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Rat
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E. coli
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Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. SLC2A1 ... |
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TMPH-02122
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SLC2A1 Protein, Human, Recombinant (His & Myc)
Glucose transporter type 1, erythrocyte/brain,HepG2...
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Human
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E. coli
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Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. SLC2A1 ... |
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TMPK-00695
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N Cadherin Protein, Human, Recombinant (hFc)
CDHN,Neural cadherin,CDH2,N-cadherin,CDw325,CD325,NCAD
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Human
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HEK293 Cells
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Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment. |
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TMPJ-01282
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Serpin B12 Protein, Human, Recombinant (His)
SERPINB12,Serine Protease Inhibitor-clade B12,Serpin B12
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Human
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HEK293 Cells
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Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Serpin B12 is expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine. Serpins are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysi... |
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TMPJ-01398
|
ITM2B Protein, Human, Recombinant (His)
Transmembrane Protein BRI,Protein E25B,BRI2,imBRI2,Immature ...
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Human
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HEK293 Cells
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Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervou... |
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TMPH-03756
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Wnt7b Protein, Human, Recombinant (His & Myc & SUMO)
Protein Wnt-7b,WNT7B
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Human
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E. coli
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Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Wint7b Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 56.3 kDa and ... |
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TMPY-01718
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Serpin B12 Protein, Mouse, Recombinant (His)
2300003F07Rik,4833409F13Rik,serpin peptidase inhibitor, clad...
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Mouse
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Baculovirus Insect Cells
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Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Mouse SerpinB12 is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. It ... |
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TMPH-03250
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NPR3 Protein, Rat, Recombinant (His & SUMO)
Npr3,Atrial natriuretic peptide receptor 3,Atrial natriureti...
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Rat
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E. coli
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Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system wi... |
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TMPH-00985
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NPR3 Protein, Human, Recombinant (His)
Atrial natriuretic peptide receptor type C,Atrial natriureti...
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Human
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E. coli
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Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. NPR3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-... |
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TMPJ-00243
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Serpin B6 Protein, Human, Recombinant (E. coli, His)
CAP,PI6,SERPINB6,Placental Thrombin Inhibitor,Cytoplasmic An...
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Human
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E. coli
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Serpin B6 belongs to the serpin family. Serpin B6 localizes to the cytoplasm. Serpin B6 is expressed in many tissues, abundantly by mast cells in different tissues and mastocytoma lesions. Serpin B6 may be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. In addition, Serpin B6 may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and se... |
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TMPY-04327
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VEGFB Protein, Human, Recombinant (hFc)
VRF,血管内皮生长因子,vascular endothelial growth factor B,VEGFL
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Human
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HEK293 Cells
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Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positively prevent the Ang II-induced rising in the size of cardiomyocyte as well as reduce Ang II-induced mRNA and protein levels of β-MHC (β-myosin heavy chain), BNP (brain natriuretic peptide), and ANP (atrial natriuretic peptide). Moreover, VEGFB can regulate the decline of the Ang I... |
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TMPK-01048
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Aggrecan Protein, Human, Recombinant (His)
CSPG1,MSK16,AGC1,ACAN
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Human
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HEK293 Cells
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Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vess... |
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TMPJ-00114
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EFNA3 Protein, Mouse, Recombinant (hFc)
EFL2,LERK-3,EFNA3,Ephrin-A3,EHK1-L,EPLG3,EFL-2,EHK1 Ligand,L...
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Mouse
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HEK293 Cells
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Ephrins-A3 belongs the Ephrins ligand family which involved in a variety of biological processes, especially in the nervous system and in erythropoiesis. It is shown that Ephrin-A3 is expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes. Ephrin-A3 has a GPI anchor following the extracellular sequence and a signal sequence of 22 amino acids. Ephrin-A3 can bind EphA2, EphA3, EphA4, EphA5, EphA6, EphA7, EphA8 and EphB1. Futhe... |
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TMPJ-01061
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Nucleobindin-2 Protein, Human, Recombinant
NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa...
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Human
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E. coli
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Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ... |
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TMPJ-00763
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ANG Protein, Human, Recombinant
RNASE5,ANG,Angiogenin,Ribonuclease 5,血管生成素,RNase 5
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Human
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E. coli
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Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin... |
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TMPY-03109
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PHYH Protein, Human, Recombinant
PHYH1,RD,PAHX,LN1,phytanoyl-CoA 2-hydroxylase,LNAP1
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Human
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E. coli
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PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. It converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Defects in PHYH can cause Refsum disease (RD). RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentos... |
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TMPY-03340
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MAP1LC3A Protein, Human, Recombinant (His)
LC3,ATG8E,microtubule-associated protein 1 light chain 3 alp...
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Human
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E. coli
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LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. As a light chain subunit, MAP1LC3A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and r... |
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TMPJ-00990
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S100B Protein, Mouse, Recombinant (His)
S-100 protein subunit beta,S-100 protein beta chain,S100b,S1...
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Mouse
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E. coli
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S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal flui... |
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TMPY-03658
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ETHE1 Protein, Human, Recombinant (His)
YF13H12,HSCO,ethylmalonic encephalopathy 1
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Human
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E. coli
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ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en... |
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TMPJ-01000
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CCL9 Protein, Mouse, Recombinant
Macrophage inflammatory protein 1-gamma,Macrophage inflammat...
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Mouse
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E. coli
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C-C motif chemokine 9(CCL9) is an 11 kDa, secreted, monomeric polypeptide that belongs to the beta (or CC) intercrine family of chemokines. It is expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain. Monokine has inflammatory, pyrogenic and chemokinetic properties. It circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor，it activates calcium release in neutrophils... |
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TMPY-02950
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WWP2 Protein, Human, Recombinant (His & GST)
WW domain containing E3 ubiquitin protein ligase 2,AIP2,WWp2...
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Human
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Baculovirus Insect Cells
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WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6... |
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TMPH-02855
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PML Protein, Mouse, Recombinant (His & Myc)
Protein PML,Pml
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Mouse
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E. coli
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Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosp... |
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TMPY-02081
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PDE2A Protein, Human, Recombinant (aa 215-900, His)
phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...
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Human
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Baculovirus Insect Cells
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cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ... |
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TMPY-02839
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Adrenomedullin Protein, Human, Recombinant (hFc)
AM,PAMP,adrenomedullin
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Human
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HEK293 Cells
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Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report... |
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TMPY-01879
|
S100A14 Protein, Human, Recombinant (His)
S100 calcium binding protein A14,BCMP84,S100A15
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Human
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E. coli
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S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that the protein is 100% soluble in ammonium sulfate at neutral pH. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from theneural crest, chondrocytes, macrophages, dendritic cells, etc. S100 proteins have been implicated in a variety of in... |
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TMPY-01734
|
CA13 Protein, Human, Recombinant (His)
carbonic anhydrase XIII,FLJ37995,CAXIII,MGC59868
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Human
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E. coli
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The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. The CAXIII is a member of th... |
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TMPY-04461
|
TRIB3 Protein, Human, Recombinant (GST)
SKIP3,C20orf97,tribbles pseudokinase 3,TRB3,SINK,NIPK
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Human
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Baculovirus Insect Cells
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Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family and Tribbles subfamily. Highest expression Of TRIB3 is in liver, pancreas, peripheral blood leukocytes and bone marrow. It is also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is expressed in spleen, thymus, and prostate an... |
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TMPY-02242
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Serpin B6 Protein, Human, Recombinant (His)
DKFZp686I04222,PTI,SPI3,PI-6,RP1-90J20.6,serpin peptidase in...
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Human
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Baculovirus Insect Cells
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SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-6 is an inhibitor of cathepsin G, kallikrein-8 and thrombin. It may play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. SerpinB6 / PI-6 is ex... |
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