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PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。
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PFK-015 (PFK15) 是一种有效的 PFKFB3 抑制剂,对重组PFKFB3的IC50为110 nM。它能抑制 Y 细胞中的 PFKFB3 活性,IC50为20 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 197 | 现货 | |
5 mg | ¥ 452 | 现货 | |
10 mg | ¥ 651 | 现货 | |
25 mg | ¥ 1,250 | 现货 | |
50 mg | ¥ 2,250 | 现货 | |
100 mg | ¥ 3,380 | 现货 | |
200 mg | ¥ 4,690 | 现货 | |
500 mg | ¥ 7,220 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 489 | 现货 |
产品描述 | PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM). |
靶点活性 | PFKFB3:110 nM, PFKFB3:20 nM |
体外活性 | PFK-015(25 mg/kg,i.p.)对同源小鼠体内LLC肿瘤的生长、转移扩散及葡萄糖代谢具有抑制作用.在三个人异种移植的无胸腺癌症小鼠模型中,PFK-015与公认化疗药物的抗癌效果相似.PFK-015有适当的体内药代动力学性质. |
体内活性 | 在Jurkat T-细胞白血病细胞和H522肺腺癌细胞中,PFK-015可使F26BP、葡萄糖摄取及细胞内腺嘌呤核苷三磷酸水平降低。PFK-015还对一系列癌细胞的生长具有明显的抑制作用。 |
激酶实验 | Recombinant PFKFB3 assay: Kinase reactions are conducted by incubating 13 ng of recombinant human PFKFB3 protein in a reaction mix containing 10 μmol/L ATP, 10 μmol/L F6P, and either dimethyl sulfoxide (DMSO) vehicle control, 3PO, or PFK15 for 1 hour at room temperature. Kinase activity is measured with the Adapta Universal Kinase Assay per manufacturer |
细胞实验 | Viability is determined using trypan blue exclusion. Cells were incubated in 20% trypan blue for 5 minutes. Cells excluding trypan blue are counted using a standard hemocytometer to determine the total number of viable cells. Experiments are conducted in triplicate. (Only for Reference) |
别名 | PFK15, PFK 015 |
分子量 | 260.29 |
分子式 | C17H12N2O |
CAS No. | 4382-63-2 |
Smiles | O=C(\C=C\c1ccc2ccccc2n1)c1ccncc1 |
密度 | 1.237 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 3 mg/mL (11.53 mM), Sonication is recommended. | ||||||||||||||||||||
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