Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.

在雌激素受体(ER)阳性的MCF7和T47D细胞中，OXY诱导TNFα表达和TNFR1降解，表明这些细胞系中发生了自分泌受体介导的凋亡。最后，在MCF7异种移植模型中，腹腔内给予OXY抑制了肿瘤生长，伴随eIF2α的磷酸化和TNFR1的降解。OXY引发的多方面细胞饥饿反应，最终诱导程序性细胞死亡[1]。

Total RNA was isolated from MCF7 cells treated with 10 μmol/L OXY for 24 h and the microarray procedure performed as described previously using the GeneChip Human U133 plus 2.0 array . Pairwise analysis was performed on control versus treated arrays using a fivefold change cutoff, <0.01 adjusted P-value, GC-RMA normalization with Benjamini–Hochberg false discovery estimation[1].