Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced inflammatory responses in macrophages.

方法：人结直肠癌细胞 LoVo 和 HCT116 用 Dexamethasone (10-300 µM) 处理 72 h，使用 MTT 方法检测细胞生长抑制情况。
结果：Dexamethasone 剂量依赖性地抑制 LoVo 和 HCT116 细胞生长，300 µM Dexamethasone 对细胞生长的抑制率分别为 52.6% 和 58.8%。[1]
方法：急性淋巴性白血病细胞 RS4;11 用 Dexamethasone (100 nM) 处理 24-36 h，使用电子显微镜检查细胞形态。
结果：在 Dexamethasone 处理 24  h 的细胞中，液泡被双膜包围，这是自噬体的特征，并含有膜结构和/或部分内质网或大量细胞质。除了自噬体的出现外，细胞核和细胞形态最初是完整的，这表明自噬体形成先于细胞死亡。Dexamethasone 诱导自噬。[2]
方法：活化的小鼠和人类 T 细胞用 Dexamethasone (0.001-10 μM) 处理 48 h，使用 Flow Cytometry 方法检测 PD-1 的表达。
结果：Dexamethasone 增强小鼠和人活化 T 细胞中 PD-1 的表达。[3]

方法：为研究抗炎作用，将 Dexamethasone (1-10 mg/kg) 单次腹腔注射给 LPS 诱导的炎症 C57Bl/6JBom 小鼠。
结果：10 mg/kg Dexamethasone 可显著减少支气管肺泡灌洗液中的中性粒细胞。Dexamethasone 治疗使 TNF-α、IL-1α、IL-1β、IL-6、IL-12p40 和 MIP-1α mRNA 水平显著下调。Dexamethasone 在急性气道炎症中发挥抗炎和抗氧化作用。[4]
方法：为检测体内抗肿瘤活性，将 Dexamethasone (1 mg/kg) 腹腔注射给携带人骨髓瘤肿瘤 OPM2 的 SCID 小鼠，每周五天，持续三周。
结果：Dexamethasone 治疗显著抑制 OPM2 肿瘤的生长，表明在体内具有抗肿瘤活性。[5]

NAC was administered at three different doses (10, 100 and 500 mg/kg body weight). At the highest concentration, the acidic pH of the NAC solution was adjusted by adding NaOH. Dexamethasone was administered as a single injection of 1 or 10 mg/kg. Both drugs were dissolved in saline and 400 μl were injected intraperitoneally, either 1 h before or 1 h after LPS exposure. In one experiment, NAC (100 and 500 mg/kg) was injected successively every 4·5 h, starting 1 h before challenge (five injections in total). A control group of LPS-exposed animals were injected intraperitoneally with solvent alone (saline). Intratracheal administration was performed by instillation of 100 μl NAC (50, 100 or 500 mg/kg) or dexamethasone (10 mg/kg) into the lungs of mice anaesthetized with 15 mg/kg Rapinovet (i.v.) [4].