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TBHQ (tert-Butylhydroquinone) 是一种抗氧化剂,可通过对氧化还原敏感的转录因子 Nrf2 诱导抗氧化反应。它也是一种ERK 激活剂,逆转 Dehydrocorydaline 对黑素瘤细胞增殖的抑制作用。
TBHQ (tert-Butylhydroquinone) 是一种抗氧化剂,可通过对氧化还原敏感的转录因子 Nrf2 诱导抗氧化反应。它也是一种ERK 激活剂,逆转 Dehydrocorydaline 对黑素瘤细胞增殖的抑制作用。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | ¥ 153 | 现货 | |
500 mg | ¥ 331 | 现货 | |
1 g | ¥ 415 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 365 | 现货 |
产品描述 | TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2. |
体外活性 | HeLa细胞经t2,5-Di-tert-butylhydroquinone处理后,表现出对线粒体硫氧还蛋白-2(Trx2)的优先氧化,而细胞内谷胱甘肽和细胞质硫氧还蛋白-1未受影响。t2,5-Di-tert-butylhydroquinone处理促使Trx2过表达抑制了Nrf2的积累和活性[1]。在用t2,5-Di-tert-butylhydroquinone预处理Jurkat T细胞,并随之用抗CD3/抗CD28激活之前,能显著降低白介素-2(IL-2)在转录和蛋白水平上的产生。同样,CD25的表达也在经t2,5-Di-tert-butylhydroquinone预处理后减少,尽管此减少的程度较IL-2为轻[2]。 |
体内活性 | TBHQ处理预防了TAC诱导的左室扩张和心脏功能障碍,并降低了心肌细胞凋亡的发生率。TBHQ诱导的Akt激活伴随着Bad、糖原合成酶激酶-3β(GSK-3β)和哺乳动物雷帕霉素靶蛋白(mTOR)的磷酸化增加。体内阻断Akt通路加速了心脏功能障碍,并消除了TBHQ的保护效果。TBHQ还减少了应激心肌中的反应性醛类产物和蛋白质氧化的产生[3]。 |
细胞实验 | Jurkat T cells were cultured in 96-well plates (1×10^5 cells/well) and treated as described, and cell supernatants were harvested 24h after activation with anti-CD3/anti-CD28. IL-2 was quantified from cell supernatants by the use of a commercially available kit per the manufacturer's protocol. Relative light intensity was quantified at 450nm by Bio-Tek μQuant microplate reader. The IL-2 concentrations of each sample were then calculated using a line ar standard curve on Microsoft Excel [2]. |
动物实验 | TBHQ powder was directly mixed with the animal food powder at a ratio of 1% (w/w) as described previously. The efficacy of this protocol for TBHQ treatment in vivo has also been validated by other groups. TBHQ treatment was continued for 4 weeks after the TAC surgery [3]. |
别名 | 特丁基对苯二酚, 叔丁基氢醌, tert-Butylhydroquinone |
分子量 | 166.22 |
分子式 | C10H14O2 |
CAS No. | 1948-33-0 |
Smiles | C(C)(C)(C)C1=C(O)C=CC(O)=C1 |
密度 | 295 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (300.81 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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