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JIB-04 (NSC 693627) 是一种 Jumonji 组蛋白去甲基酶广谱抑制剂,能抑制 JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C 和 JMJD2D 的活性,其IC50值分别为 230、340、855、445、435、1100 和 290 nM。
JIB-04 (NSC 693627) 是一种 Jumonji 组蛋白去甲基酶广谱抑制剂,能抑制 JARID1A、JMJD2E、JMJD3、JMJD2A、JMJD2B、JMJD2C 和 JMJD2D 的活性,其IC50值分别为 230、340、855、445、435、1100 和 290 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 183 | 现货 | |
2 mg | ¥ 255 | 现货 | |
5 mg | ¥ 396 | 现货 | |
10 mg | ¥ 567 | 现货 | |
25 mg | ¥ 963 | 现货 | |
50 mg | ¥ 1,490 | 现货 | |
100 mg | ¥ 2,380 | 现货 | |
200 mg | ¥ 3,530 | 现货 | |
500 mg | ¥ 5,650 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 519 | 现货 |
产品描述 | JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor. |
靶点活性 | JMJD2E:340 nM, JMJD2D:290 nM, JMJD2B:435 nM, JARID1A:230 nM, JMJD2A:445 nM |
体外活性 | 在H358和A549小鼠异种移植模型中,JIB-04抑制Jumonji组蛋白脱甲基酶的活性,抑制肿瘤细胞生长. |
体内活性 | 在肺癌和前列腺癌细胞系中(IC50=10 nM),JIB-04下调增殖基因,阻断细胞生长。 |
细胞实验 | For cell viability assays, cells are plated at 1500-3000 cells/well in 96 well plates and treated the next day with increasing doses of compound over 4 days and their viability assessed by standard MTS assays using Promega’s Cell Titer or Cell Titer-Glo reagents according to the manufacturer’s protocols. Absorbance at 490 nm and 650 nm or luminescence is measured by a Spectra Max or a FlouroStar Omega plate reader. Data are normalized to the untreated controls (100% viability). Each cell line is tested in 2-5 independent assays, each containing 4-8 replicates. IC50 values are calculated using DIVISA, a high-throughput software, developed in hous, for storing and analyzing drug sensitivity assays. Dose-response curves are plotted using a non-linear regression model and IC50s are determined from the fitted curves. The average IC50 derived from 2-5 independent assays, each containing 4-8 replicates is reported. (Only for Reference) |
别名 | NSC 693627, JIB 04, 5-氯-2(1H)-吡啶酮 (2E)-(苯基-2-吡啶基亚甲基)腙 |
分子量 | 308.76 |
分子式 | C17H13ClN4 |
CAS No. | 199596-05-9 |
Smiles | Clc1ccc(N\N=C(/c2ccccc2)c2ccccn2)nc1 |
密度 | 1.24 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (161.94 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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