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Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂,能够抑制 MET (IC50:2.7 nM),TIE2 (IC50:8 nM),VEGFR2 (IC50:9.2 nM),FLT3 (IC50:9.3 nM),Trk1 (IC50:0.85 nM),Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
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Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂,能够抑制 MET (IC50:2.7 nM),TIE2 (IC50:8 nM),VEGFR2 (IC50:9.2 nM),FLT3 (IC50:9.3 nM),Trk1 (IC50:0.85 nM),Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 176 | 现货 | |
5 mg | ¥ 455 | 现货 | |
10 mg | ¥ 747 | 现货 | |
25 mg | ¥ 1,280 | 现货 | |
50 mg | ¥ 1,980 | 现货 | |
100 mg | ¥ 3,730 | 现货 | |
500 mg | ¥ 7,880 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 513 | 现货 |
产品描述 | Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro. |
靶点活性 | MET (Y1230C):0.37 nM, MET (Y1230C):1.2 nM, TrkA:0.85 nM, TrkC:0.85 nM, MET (D1228N):1.3 nM |
别名 | DCC-2701 |
分子量 | 510.46 |
分子式 | C26H21F3N4O4 |
CAS No. | 1345847-93-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 45 mg/mL (88.15 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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