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HO-3867是一种 STAT3的选择性有效抑制剂,有抗肿瘤活性。
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HO-3867是一种 STAT3的选择性有效抑制剂,有抗肿瘤活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 328 | 现货 | |
2 mg | ¥ 458 | 现货 | |
5 mg | ¥ 663 | 现货 | |
10 mg | ¥ 1,060 | 现货 | |
25 mg | ¥ 2,120 | 现货 | |
50 mg | ¥ 3,390 | 现货 | |
100 mg | ¥ 5,390 | 现货 | |
200 mg | ¥ 7,360 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 678 | 现货 |
产品描述 | HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor. |
激酶实验 | Scintillation Proximity Assay, 125I-FGF-2 Binding: SPA protein A beads are supplied as a suspension in PBS at 20 mg/mL, then diluted with binding buffer (KCl, 400 mg/L; MgSO4 200 mg/L; NaCl 6.4 g/L; NaHCO3 3.7 g/L; NaH2PO4 0.141 mg/mL; bis Tris Propane 11.292 g/L; Glucose 4.5 g/L; Gelatin 0.1 %; pH 7.0) at 10 mg/mL. 125I-FGF-2 radioligand and FGFR-1IIIc? - Fc Chimera are diluted into binding buffer. Binding was performed on 96-well plates coated with 0.1 % gelatin. Total assay volume is 0.1 mL. Binding of 125I-FGF-2 is determined by incubation of SPA beads coated with protein A (0.5 mg/assay) with FGFR-1IIIc? - Fc chimera soluble receptor (5 ng/assay), FGF-2 (20 ng/assay) is used for non-specific binding determinations. |
细胞实验 | Cell viability is determined by a colorimetric assay using MTT. In the mitochondria of living cells, yellow MTT undergoes a reductive conversion to formazan, producing a purple color. Cells, grown to ~80% confluence in 75-mm flasks, are trypsinized, counted, seeded in 96-well plates with an average population of 7,000 cells/well, incubated overnight, and then treated with HO-3867 for 24 h. All experiments are done using 8 replicates and repeated at least three times. (Only for Reference) |
别名 | HO3867 |
分子量 | 464.55 |
分子式 | C28H30F2N2O2 |
CAS No. | 1172133-28-6 |
Smiles | CC1(C)C=C(CN2C\C(=C/c3ccc(F)cc3)C(=O)\C(C2)=C\c2ccc(F)cc2)C(C)(C)N1O |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: 6 mg/mL (12.91 mM), Heating is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 11 mg/mL (23.7 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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