Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂,IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制,可抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚,有抗肿瘤作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 686 | 现货 | ||
5 mg | ¥ 1,670 | 现货 | ||
10 mg | ¥ 2,810 | 现货 | ||
25 mg | ¥ 4,590 | 现货 | ||
50 mg | ¥ 6,480 | 现货 | ||
100 mg | ¥ 8,760 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,720 | 现货 |
产品描述 | Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF. |
体外活性 | 8-Gingerol has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively) [1]. |
体内活性 | In vivo, 8-Gingerol reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3]. |
别名 | 茶黄素-3,3'-双没食子酸, 8-Gingerol, TFDG |
分子量 | 868.7 |
分子式 | C43H32O20 |
CAS No. | 30462-35-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (11.51 mM)
Ethanol: 10 mg/mL
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.1511 mL | 5.7557 mL | 11.5115 mL | 28.7786 mL |
5 mM | 0.2302 mL | 1.1511 mL | 2.3023 mL | 5.7557 mL | |
10 mM | 0.1151 mL | 0.5756 mL | 1.1511 mL | 2.8779 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Theaflavin 3,3'-digallate 30462-35-2 Microbiology/Virology oxidation-reduction Proteases/Proteasome Virus Protease Antioxidant HIV Protease HSV TF 3 TF3 ZIKV Theaflavin 3,3' digallate ZP10 HIV Human immunodeficiency virus replication ERK1/2 p53 p21 Akt U87 ZP 10 MAPK translation 茶黄素-3,3'-双没食子酸 gp41 8-Gingerol Inhibitor NF-κB Theaflavin 3,3'digallate NS3 Herpes simplex virus TFDG NS2B-3 inhibit ZP-10 TF-3 inhibitor