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CIB-1476为一种有效的caspase-1抑制剂,主要通过抑制NLRP3炎性小体诱导的IL-1β生成、NF-κB活化以及GSDMD介导的焦亡(pyroptosis),从而展现出持久的抗炎效果。此外,CIB-1476在关节炎小鼠模型中能够有效抑制关节肿胀。
CIB-1476为一种有效的caspase-1抑制剂,主要通过抑制NLRP3炎性小体诱导的IL-1β生成、NF-κB活化以及GSDMD介导的焦亡(pyroptosis),从而展现出持久的抗炎效果。此外,CIB-1476在关节炎小鼠模型中能够有效抑制关节肿胀。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome. |
分子量 | 520.6 |
分子式 | C28H28N2O6S |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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