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Gossypol (BL 193) 是一种多酚醛,可渗透细胞并作为几种脱氢酶的抑制剂。它分别与 Bcl-xL 蛋白和Bcl-2蛋白结合,Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。
Gossypol (BL 193) 是一种多酚醛,可渗透细胞并作为几种脱氢酶的抑制剂。它分别与 Bcl-xL 蛋白和Bcl-2蛋白结合,Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥ 153 | 现货 | |
25 mg | ¥ 233 | 现货 | |
50 mg | ¥ 328 | 现货 | |
100 mg | ¥ 578 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 363 | 现货 |
产品描述 | Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. |
靶点活性 | BCL-XL:0.5-0.6 μM (Ki), BCL2:0.2-0.3 mM (Ki) |
体外活性 | Gossypol,一种已知的源自棉属植物的抗精子生成剂,在体外抑制黄鲈鱼精子的活力,并且当按剂量依赖的方式使用时,能够抑制精子中的乳酸脱氢酶活性[1]。此外,Gossypol 在体外对某些癌细胞系显示出了抗增殖和诱导凋亡的效果[2]。 |
细胞实验 | MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference) |
别名 | Pogosin, BL 193, 棉酚, NSC 56817 |
分子量 | 518.55 |
分子式 | C30H30O8 |
CAS No. | 303-45-7 |
存储 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (96.42 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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