Propiomazine is an orally active antihistamine agent that possesses sedative properties. It finds utility in insomnia research [1] [2].

Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations [3]. Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl 4 -induced hepatic injury [4]. Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats [5].