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SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 497 | 现货 | |
5 mg | ¥ 990 | 现货 | |
10 mg | ¥ 1,580 | 现货 | |
25 mg | ¥ 2,890 | 现货 | |
50 mg | ¥ 3,970 | 现货 | |
100 mg | ¥ 5,790 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,090 | 现货 |
产品描述 | SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist. |
体外活性 | SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells. |
体内活性 | In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities. |
动物实验 | Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference) |
别名 | Smoothened Agonist HCl |
分子量 | 526.52 |
分子式 | C28H29Cl2N3OS |
CAS No. | 2095432-58-7 |
Smiles | Cl.CN[C@H]1CC[C@@H](CC1)N(Cc1cccc(c1)-c1ccncc1)C(=O)c1sc2ccccc2c1Cl |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: 38 mg/mL (72.2 mM) DMSO: 66 mg/mL (125.4 mM) | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
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