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3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
100 mg | 询价 | 5日内发货 | |
500 mg | 询价 | 5日内发货 |
产品描述 | 3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it exhibits greater cytotoxicity compared to PKC412[1]. |
靶点活性 | FLT3 (plasma):9.8 μM, FLT3 (culture medium):132 nM |
体外活性 | CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412, When the dose over range 100 to 500 nM[1]. |
别名 | CGP52421 |
分子量 | 586.648 |
分子式 | C35H30N4O5 |
CAS No. | 179237-49-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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