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GSK0660 是 PPARβ/δ 的拮抗剂和反向激动剂,IC50均为155 nM。
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GSK0660 是 PPARβ/δ 的拮抗剂和反向激动剂,IC50均为155 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 295 | 现货 | |
2 mg | ¥ 418 | 现货 | |
5 mg | ¥ 672 | 现货 | |
10 mg | ¥ 990 | 现货 | |
25 mg | ¥ 1,970 | 现货 | |
50 mg | ¥ 3,660 | 现货 | |
100 mg | ¥ 5,330 | 现货 | |
500 mg | ¥ 10,900 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 739 | 现货 |
产品描述 | GSK0660 is an antagonist and inverse agonist of PPARβ/δ. |
靶点活性 | PPARβ/δ:155 nM |
激酶实验 | Human astrocytoma cells, 1321N1, are grown to stably express rat P2X7, human P2X4, P2X2a, P2X2/3, P2X1, P2Y1?and P2Y2 recombinant receptors. Agonist, BzATP, 2,3-O-(4-ben-zoylbenzoyl)-ATP or ATP-induced changes in intracellular Ca2+?concentrations are assessed in all of the cell lines using the Ca2+?chelating dye, Fluo-4, in conjunction with a Fluorometric Imaging Plate Reader. The cells are plated out the day before the experiment onto poly-D-lysine-coated black 96 well plates. After the agonist addition, changes in intracellular Ca2+ concentrations are recorded, per second, for 3 min. Ligands are tested at 11 half-log concentrations from 10-10 to 10-4 M. BzATP or ATP concentrations corresponds to the EC70?values for each receptor to enable comparison of antagonist potencies across the multiple P2 receptor subtypes. A 438079 is added to the cell plate and ?uorescence data are collected for 3 min before the addition of agonist, subsequently, data are then collected for another 2 min. The pEC50 or pIC50 values are derived from a single curve ?t. |
分子量 | 418.49 |
分子式 | C19H18N2O5S2 |
CAS No. | 1014691-61-2 |
Smiles | S(NC1=C(OC)C=C(NC2=CC=CC=C2)C=C1)(=O)(=O)C3=C(C(OC)=O)SC=C3 |
密度 | 1.413 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: 4.18 mg/mL (10 mM) DMSO: 50 mg/mL (119.48 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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