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Adefovir 是一种单磷酸腺苷类似物抗病毒剂,在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。
Adefovir 是一种单磷酸腺苷类似物抗病毒剂,在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥ 272 | 现货 | |
25 mg | ¥ 417 | 现货 | |
50 mg | ¥ 671 | 现货 | |
100 mg | ¥ 980 | 现货 |
产品描述 | Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment of hepatitis B and herpes simplex virus infection. |
体外活性 | Adefovir是一种强效的DHBV复制抑制剂,能够抑制CCC DNA的扩增,但并不能有效阻止来自入侵病毒基因组的CCC DNA形成[1]。 |
细胞实验 | The effect of adefovir on viral CCC DNA synthesis was examined with primary cultures of DHBV-infected fetal hepatocytes.?Adefovir was administered for six consecutive days starting one day before or four days after DHBV inoculation.?Dose-dependent inhibition of both virion release in culture supernatants and synthesis of intracellular viral DNA was observed[1]. |
别名 | 阿德福韦 |
分子量 | 273.19 |
分子式 | C8H12N5O4P |
CAS No. | 106941-25-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
溶解度信息 | H2O: 2.5 mM DMSO: Insoluble | ||||||||||
溶液配制表 | |||||||||||
H2O
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