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Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 18,300 | 10-14周 | |
50 mg | ¥ 24,300 | 10-14周 | |
100 mg | ¥ 31,500 | 10-14周 |
产品描述 | Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM). |
靶点活性 | TYK2:485 nM |
体内活性 | Tyk2-IN-3 is very potent Tyk2 pseudokinase against (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3). |
分子量 | 520.63 |
分子式 | C25H24N6O3S2 |
CAS No. | 1779493-12-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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