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SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂,IC50 为 22 µM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。
SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂,IC50 为 22 µM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 618 | 现货 | |
5 mg | ¥ 1,470 | 现货 | |
10 mg | ¥ 2,310 | 现货 | |
25 mg | ¥ 3,890 | 现货 | |
50 mg | ¥ 5,580 | 现货 | |
100 mg | ¥ 7,820 | 现货 |
产品描述 | SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers. |
靶点活性 | TNF-α:22 µM |
体外活性 | The survivability of aHSCs is significantly rescued by SPD304 dihydrochloride (2 μM). The production of lipid hydroxides and intracellular GSH are increased as well. GA (75 μM) and SPD304 dihydrochloride (2 μM) downregulate TRADD (almost 2-fold) and p−RIP3 (1.4−fold) compared to GA and promote the activation of caspase 8[4]. |
分子量 | 620.53 |
分子式 | C32H34Cl2F3N3O2 |
CAS No. | 1049741-03-8 |
Smiles | O=C1C2=C(OC=C1CN(CCN(CC3=CN(C4=C3C=CC=C4)C5=CC=CC(C(F)(F)F)=C5)C)C)C=C(C)C(C)=C2.Cl.Cl |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 6.2 mg/mL (10 mM) | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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