DG172 dihydrochloride

产品编号 T7821Cas号 1361504-77-9

别名 DG172 (dihydrochloride)|||DG-172 dihydrochloride

DG172 dihydrochloride (DG-172 dihydrochloride) 是一种 PPARβ/δ拮抗剂，IC50值为 27 nM。

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产品编号 T7821别名 DG172 (dihydrochloride), DG-172 dihydrochlorideCas号 1361504-77-9

DG172 dihydrochloride (DG-172 dihydrochloride) 是一种 PPARβ/δ拮抗剂，IC50值为 27 nM。

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生物活性

产品描述	DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).
靶点活性	PPARβ/δ:27 nM
体外活性	DG172 is a novel PPARβ/δ-selective ligand showing high binding affinity (IC(50) = 27 nM) and potent inverse agonistic properties.?DG172 selectively inhibited the agonist-induced activity of PPARβ/δ, enhanced transcriptional corepressor recruitment, and down-regulated transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC(50) = 9.5 nM).?Importantly, DG172 was bioavailable after oral application to mice with peak plasma levels in the concentration range of its maximal inhibitory potency, suggesting that 37 will be an invaluable tool to elucidate the functions and therapeutic potential of PPARβ/δ[1].
别名	DG172 (dihydrochloride), DG-172 dihydrochloride

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抗原信息

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化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 14.29 mg/mL (31.39 mM), Sonication is recommended.

溶液配制表

H2O